Disturbances in the Mechanism of Apoptosis as One of the Causes of the Development of Cancer Diseases
Apoptosis is a genetically programmed process that affects all multicellular organisms. This mechanism of programmed cell death is designed to protect the body against uncontrolled proliferation of cells with impaired functions. Apoptosis can occur through two major pathways. The extrinsic, initiate...
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Uniwersytet Kardynała Stefana Wyszyńskiego w Warszawie
2020-12-01
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| Series: | Studia Ecologiae et Bioethicae |
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| Online Access: | https://czasopisma.uksw.edu.pl/index.php/seb/article/view/7526 |
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| author | Paweł Rusin Karolina Jabłońska |
| author_facet | Paweł Rusin Karolina Jabłońska |
| author_sort | Paweł Rusin |
| collection | DOAJ |
| description | Apoptosis is a genetically programmed process that affects all multicellular organisms. This mechanism of programmed cell death is designed to protect the body against uncontrolled proliferation of cells with impaired functions. Apoptosis can occur through two major pathways. The extrinsic, initiated by signals from the death receptor, and the intrinsic one, resulting from a change in the permeability of the external mitochondrial membrane due to stress factors promoting the initiation of programmed cell death. Apoptosis may be influenced by many factors that may lead to suppressing the initiation of apoptotic pathways, and the damaged cell will develop, divide, and over time transform into a cancerous cell. As a result, cancer cells will be resistant to the applied chemo- and radiotherapy. The mechanisms responsible for apoptosis regulation are impaired, what eliminates the effects of therapies aimed at initiating this type of cell death. New types of molecular therapies provide an opportunity to increase the effectiveness of anticancer treatment, aiming at deficient proteins and suppressing or eliminating their antiapoptotic effects. |
| format | Article |
| id | doaj-art-1757fa66bae143748526ab46e7f73a62 |
| institution | Kabale University |
| issn | 1733-1218 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | Uniwersytet Kardynała Stefana Wyszyńskiego w Warszawie |
| record_format | Article |
| series | Studia Ecologiae et Bioethicae |
| spelling | doaj-art-1757fa66bae143748526ab46e7f73a622025-02-02T23:46:35ZengUniwersytet Kardynała Stefana Wyszyńskiego w WarszawieStudia Ecologiae et Bioethicae1733-12182020-12-0118410.21697/seb.2020.18.4.06Disturbances in the Mechanism of Apoptosis as One of the Causes of the Development of Cancer DiseasesPaweł Rusin0Karolina Jabłońska1Institute of Biological Sciences, Cardinal Stefan Wyszyński University in Warsaw,Student Club of Molecular Biology, Cardinal Stefan Wyszyński University in Warsaw,Apoptosis is a genetically programmed process that affects all multicellular organisms. This mechanism of programmed cell death is designed to protect the body against uncontrolled proliferation of cells with impaired functions. Apoptosis can occur through two major pathways. The extrinsic, initiated by signals from the death receptor, and the intrinsic one, resulting from a change in the permeability of the external mitochondrial membrane due to stress factors promoting the initiation of programmed cell death. Apoptosis may be influenced by many factors that may lead to suppressing the initiation of apoptotic pathways, and the damaged cell will develop, divide, and over time transform into a cancerous cell. As a result, cancer cells will be resistant to the applied chemo- and radiotherapy. The mechanisms responsible for apoptosis regulation are impaired, what eliminates the effects of therapies aimed at initiating this type of cell death. New types of molecular therapies provide an opportunity to increase the effectiveness of anticancer treatment, aiming at deficient proteins and suppressing or eliminating their antiapoptotic effects.https://czasopisma.uksw.edu.pl/index.php/seb/article/view/7526apoptosiscancerdisorders of the apoptotic mechanismstargeted treatment |
| spellingShingle | Paweł Rusin Karolina Jabłońska Disturbances in the Mechanism of Apoptosis as One of the Causes of the Development of Cancer Diseases Studia Ecologiae et Bioethicae apoptosis cancer disorders of the apoptotic mechanisms targeted treatment |
| title | Disturbances in the Mechanism of Apoptosis as One of the Causes of the Development of Cancer Diseases |
| title_full | Disturbances in the Mechanism of Apoptosis as One of the Causes of the Development of Cancer Diseases |
| title_fullStr | Disturbances in the Mechanism of Apoptosis as One of the Causes of the Development of Cancer Diseases |
| title_full_unstemmed | Disturbances in the Mechanism of Apoptosis as One of the Causes of the Development of Cancer Diseases |
| title_short | Disturbances in the Mechanism of Apoptosis as One of the Causes of the Development of Cancer Diseases |
| title_sort | disturbances in the mechanism of apoptosis as one of the causes of the development of cancer diseases |
| topic | apoptosis cancer disorders of the apoptotic mechanisms targeted treatment |
| url | https://czasopisma.uksw.edu.pl/index.php/seb/article/view/7526 |
| work_keys_str_mv | AT pawełrusin disturbancesinthemechanismofapoptosisasoneofthecausesofthedevelopmentofcancerdiseases AT karolinajabłonska disturbancesinthemechanismofapoptosisasoneofthecausesofthedevelopmentofcancerdiseases |