Implementing enclosed sterile integrated robotic platforms to improve cell-based screening for drug discovery
At GSK, we have implemented custom integrated robotics platforms housed in bespoke biosafety enclosures to augment our capabilities in advanced cellular screening. Here we present and discuss the impact of one such system, the Cellular Automated Screening Platform (CASPer). We evaluate the benefits...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | SLAS Technology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2472630324001122 |
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| author | Alice Rockliffe Lauren Wheeler Kiran Lidhar Arun Dhar Michelle Pemberton Richard Kasprowicz Ceridwen Hopely Jo Francis Shane Marine David Brierley Lorna Suckling |
| author_facet | Alice Rockliffe Lauren Wheeler Kiran Lidhar Arun Dhar Michelle Pemberton Richard Kasprowicz Ceridwen Hopely Jo Francis Shane Marine David Brierley Lorna Suckling |
| author_sort | Alice Rockliffe |
| collection | DOAJ |
| description | At GSK, we have implemented custom integrated robotics platforms housed in bespoke biosafety enclosures to augment our capabilities in advanced cellular screening. Here we present and discuss the impact of one such system, the Cellular Automated Screening Platform (CASPer). We evaluate the benefits of implementing specific processes on CASPer that include increasing the throughput of safety screening assays and improving data integrity when testing complex in vitro 3D primary human hepatocyte models. This article provides an overview of the platforms installed and offers insight into their utilisation by presenting example workflows and quality control solutions which have been implemented. We offer perspective on the advantages of such custom integrated systems and their limitations in cellular screening for early drug discovery. |
| format | Article |
| id | doaj-art-174887628cd74f79815be2b4c5979ec9 |
| institution | Kabale University |
| issn | 2472-6303 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | SLAS Technology |
| spelling | doaj-art-174887628cd74f79815be2b4c5979ec92025-01-23T05:27:27ZengElsevierSLAS Technology2472-63032025-02-0130100230Implementing enclosed sterile integrated robotic platforms to improve cell-based screening for drug discoveryAlice Rockliffe0Lauren Wheeler1Kiran Lidhar2Arun Dhar3Michelle Pemberton4Richard Kasprowicz5Ceridwen Hopely6Jo Francis7Shane Marine8David Brierley9Lorna Suckling10Discovery Biology & Screening, GSK R&D, Stevenage, Hertfordshire, UKDiscovery Biology & Screening, GSK R&D, Stevenage, Hertfordshire, UKDiscovery Biology & Screening, GSK R&D, Stevenage, Hertfordshire, UKPerkinElmer, Stevenage, Hertfordshire, UKDiscovery Biology & Screening, GSK R&D, Stevenage, Hertfordshire, UKDiscovery Biology & Screening, GSK R&D, Stevenage, Hertfordshire, UKGenome Biology, Target Discovery, GSK R&D, Collegeville, PA, USADiscovery Biology & Screening, GSK R&D, Stevenage, Hertfordshire, UKGenome Biology, Target Discovery, GSK R&D, Collegeville, PA, USADiscovery Biology & Screening, GSK R&D, Stevenage, Hertfordshire, UKDiscovery Biology & Screening, GSK R&D, Stevenage, Hertfordshire, UK; Corresponding author.At GSK, we have implemented custom integrated robotics platforms housed in bespoke biosafety enclosures to augment our capabilities in advanced cellular screening. Here we present and discuss the impact of one such system, the Cellular Automated Screening Platform (CASPer). We evaluate the benefits of implementing specific processes on CASPer that include increasing the throughput of safety screening assays and improving data integrity when testing complex in vitro 3D primary human hepatocyte models. This article provides an overview of the platforms installed and offers insight into their utilisation by presenting example workflows and quality control solutions which have been implemented. We offer perspective on the advantages of such custom integrated systems and their limitations in cellular screening for early drug discovery.http://www.sciencedirect.com/science/article/pii/S2472630324001122Lab automationAutomated biologyIntegrated platformsCell-based screening |
| spellingShingle | Alice Rockliffe Lauren Wheeler Kiran Lidhar Arun Dhar Michelle Pemberton Richard Kasprowicz Ceridwen Hopely Jo Francis Shane Marine David Brierley Lorna Suckling Implementing enclosed sterile integrated robotic platforms to improve cell-based screening for drug discovery SLAS Technology Lab automation Automated biology Integrated platforms Cell-based screening |
| title | Implementing enclosed sterile integrated robotic platforms to improve cell-based screening for drug discovery |
| title_full | Implementing enclosed sterile integrated robotic platforms to improve cell-based screening for drug discovery |
| title_fullStr | Implementing enclosed sterile integrated robotic platforms to improve cell-based screening for drug discovery |
| title_full_unstemmed | Implementing enclosed sterile integrated robotic platforms to improve cell-based screening for drug discovery |
| title_short | Implementing enclosed sterile integrated robotic platforms to improve cell-based screening for drug discovery |
| title_sort | implementing enclosed sterile integrated robotic platforms to improve cell based screening for drug discovery |
| topic | Lab automation Automated biology Integrated platforms Cell-based screening |
| url | http://www.sciencedirect.com/science/article/pii/S2472630324001122 |
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