Efficacy of Ergosterol and Ergosterol peroxide in different anti-inflammatory models – a comparison study
Ergosterol and its peroxide with important regulatory roles in a variety of intracellular biological processes. In this study, both of the LPS- and UVA-induced human keratinocyte (HaCaT) inflammatory models were established to investigate the anti-inflammatory effects of ES and EP. The protective ef...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
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| Series: | Food and Agricultural Immunology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/09540105.2024.2423638 |
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| Summary: | Ergosterol and its peroxide with important regulatory roles in a variety of intracellular biological processes. In this study, both of the LPS- and UVA-induced human keratinocyte (HaCaT) inflammatory models were established to investigate the anti-inflammatory effects of ES and EP. The protective effects of EP and ES on UVA and LPS-induced cell damage were discussed by cell viability assays, reactive oxygen species levels, skin barrier-related proteins, anti-inflammatory factors, and expression of genes involved in related signaling pathways were analyzed. The results showed that both of ES and EP could reduce the intracellular ROS levels; inhibit IL-8 and IL-1β secretion; and had significant promotion effects on AQP3 and FLG, inhibited gene expressions of PI3K, AKt, IL-1β and IL-8 and ES and EP were not irritating according to the safety evaluation. In summary, both of ES and EP showed excellent anti-inflammatory effects and provided a degree of protection against UVA/LPS-induced inflammatory damage. |
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| ISSN: | 0954-0105 1465-3443 |