Rho-Kinase/ROCK as a Potential Drug Target for Vitreoretinal Diseases
Rho-associated kinase (Rho-kinase/ROCK) was originally identified as an effector protein of the G protein Rho. Its involvement in various diseases, particularly cancer and cardiovascular disease, has been elucidated, and ROCK inhibitors have already been applied clinically for cerebral vasospasm and...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2017/8543592 |
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| author | Muneo Yamaguchi Shintaro Nakao Mitsuru Arima Iori Wada Yoshihiro Kaizu Feng Hao Shigeo Yoshida Koh-hei Sonoda |
| author_facet | Muneo Yamaguchi Shintaro Nakao Mitsuru Arima Iori Wada Yoshihiro Kaizu Feng Hao Shigeo Yoshida Koh-hei Sonoda |
| author_sort | Muneo Yamaguchi |
| collection | DOAJ |
| description | Rho-associated kinase (Rho-kinase/ROCK) was originally identified as an effector protein of the G protein Rho. Its involvement in various diseases, particularly cancer and cardiovascular disease, has been elucidated, and ROCK inhibitors have already been applied clinically for cerebral vasospasm and glaucoma. Vitreoretinal diseases including diabetic retinopathy, age-related macular degeneration, and proliferative vitreoretinoapthy are still a major cause of blindness. While anti-VEGF therapy has recently been widely used for vitreoretinal disorders due to its efficacy, attention has been drawn to new unmet needs. The importance of ROCK in pathological vitreoretinal conditions has also been elucidated and is attracting attention as a potential therapeutic target. ROCK is involved in angiogenesis and hyperpermeability and also in the pathogenesis of various pathologies such as inflammation and fibrosis. It has been expected that ROCK inhibitors will become new molecular target drugs for vitreoretinal diseases. This review summarizes the recent progress on the mechanisms of action of ROCK and their applications in disease treatment. |
| format | Article |
| id | doaj-art-1720711474854d68982b7579c81c28bd |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-1720711474854d68982b7579c81c28bd2025-02-03T01:26:12ZengWileyJournal of Ophthalmology2090-004X2090-00582017-01-01201710.1155/2017/85435928543592Rho-Kinase/ROCK as a Potential Drug Target for Vitreoretinal DiseasesMuneo Yamaguchi0Shintaro Nakao1Mitsuru Arima2Iori Wada3Yoshihiro Kaizu4Feng Hao5Shigeo Yoshida6Koh-hei Sonoda7Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, JapanDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, JapanDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, JapanDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, JapanDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, JapanDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, JapanDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, JapanDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, JapanRho-associated kinase (Rho-kinase/ROCK) was originally identified as an effector protein of the G protein Rho. Its involvement in various diseases, particularly cancer and cardiovascular disease, has been elucidated, and ROCK inhibitors have already been applied clinically for cerebral vasospasm and glaucoma. Vitreoretinal diseases including diabetic retinopathy, age-related macular degeneration, and proliferative vitreoretinoapthy are still a major cause of blindness. While anti-VEGF therapy has recently been widely used for vitreoretinal disorders due to its efficacy, attention has been drawn to new unmet needs. The importance of ROCK in pathological vitreoretinal conditions has also been elucidated and is attracting attention as a potential therapeutic target. ROCK is involved in angiogenesis and hyperpermeability and also in the pathogenesis of various pathologies such as inflammation and fibrosis. It has been expected that ROCK inhibitors will become new molecular target drugs for vitreoretinal diseases. This review summarizes the recent progress on the mechanisms of action of ROCK and their applications in disease treatment.http://dx.doi.org/10.1155/2017/8543592 |
| spellingShingle | Muneo Yamaguchi Shintaro Nakao Mitsuru Arima Iori Wada Yoshihiro Kaizu Feng Hao Shigeo Yoshida Koh-hei Sonoda Rho-Kinase/ROCK as a Potential Drug Target for Vitreoretinal Diseases Journal of Ophthalmology |
| title | Rho-Kinase/ROCK as a Potential Drug Target for Vitreoretinal Diseases |
| title_full | Rho-Kinase/ROCK as a Potential Drug Target for Vitreoretinal Diseases |
| title_fullStr | Rho-Kinase/ROCK as a Potential Drug Target for Vitreoretinal Diseases |
| title_full_unstemmed | Rho-Kinase/ROCK as a Potential Drug Target for Vitreoretinal Diseases |
| title_short | Rho-Kinase/ROCK as a Potential Drug Target for Vitreoretinal Diseases |
| title_sort | rho kinase rock as a potential drug target for vitreoretinal diseases |
| url | http://dx.doi.org/10.1155/2017/8543592 |
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