Role of Signaling Transduction Pathways in Development of Castration-Resistant Prostate Cancer
Almost all patients who succumb to prostate cancer die of metastatic castration-resistant disease. Although docetaxel is the standard treatment for this disease and is associated with modest prolongation of survival, there is an urgent need for novel treatments for castration-resistant prostate canc...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2011/647987 |
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| _version_ | 1832556535222370304 |
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| author | Takahiro Inoue Osamu Ogawa |
| author_facet | Takahiro Inoue Osamu Ogawa |
| author_sort | Takahiro Inoue |
| collection | DOAJ |
| description | Almost all patients who succumb to prostate cancer die of metastatic castration-resistant disease. Although docetaxel is the standard treatment for this disease and is associated with modest prolongation of survival, there is an urgent need for novel treatments for castration-resistant prostate cancer (CRPC). Great advances in our understanding of the biological and molecular mechanisms of prostate cancer progression have resulted in many clinical trials of numerous targeted therapies. In this paper, we review mechanisms of CRPC development, with particular focus on recent advances in the understanding of specific intracellular signaling pathways participating in the proliferation of CRPC cells. |
| format | Article |
| id | doaj-art-17162457e64147efb796453e3e2bd777 |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-17162457e64147efb796453e3e2bd7772025-02-03T05:45:08ZengWileyProstate Cancer2090-31112090-312X2011-01-01201110.1155/2011/647987647987Role of Signaling Transduction Pathways in Development of Castration-Resistant Prostate CancerTakahiro Inoue0Osamu Ogawa1Department of Urology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho Shogoin, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Urology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho Shogoin, Sakyo-ku, Kyoto 606-8507, JapanAlmost all patients who succumb to prostate cancer die of metastatic castration-resistant disease. Although docetaxel is the standard treatment for this disease and is associated with modest prolongation of survival, there is an urgent need for novel treatments for castration-resistant prostate cancer (CRPC). Great advances in our understanding of the biological and molecular mechanisms of prostate cancer progression have resulted in many clinical trials of numerous targeted therapies. In this paper, we review mechanisms of CRPC development, with particular focus on recent advances in the understanding of specific intracellular signaling pathways participating in the proliferation of CRPC cells.http://dx.doi.org/10.1155/2011/647987 |
| spellingShingle | Takahiro Inoue Osamu Ogawa Role of Signaling Transduction Pathways in Development of Castration-Resistant Prostate Cancer Prostate Cancer |
| title | Role of Signaling Transduction Pathways in Development of Castration-Resistant Prostate Cancer |
| title_full | Role of Signaling Transduction Pathways in Development of Castration-Resistant Prostate Cancer |
| title_fullStr | Role of Signaling Transduction Pathways in Development of Castration-Resistant Prostate Cancer |
| title_full_unstemmed | Role of Signaling Transduction Pathways in Development of Castration-Resistant Prostate Cancer |
| title_short | Role of Signaling Transduction Pathways in Development of Castration-Resistant Prostate Cancer |
| title_sort | role of signaling transduction pathways in development of castration resistant prostate cancer |
| url | http://dx.doi.org/10.1155/2011/647987 |
| work_keys_str_mv | AT takahiroinoue roleofsignalingtransductionpathwaysindevelopmentofcastrationresistantprostatecancer AT osamuogawa roleofsignalingtransductionpathwaysindevelopmentofcastrationresistantprostatecancer |