The Tissue-Selective Estrogen Complex (Bazedoxifene/Conjugated Estrogens) for the Treatment of Menopause
The tissue-selective estrogen complex (TSEC) pairs conjugated estrogens (CE) with a selective estrogen receptor modulator (SERM), bazedoxifene acetate (BZA). A 2-year treatment with the TSEC improved vasomotor symptoms, quality of life, and vaginal atrophy in healthy postmenopausal women. In additio...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/5064725 |
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| author | Stefano Lello Anna Capozzi Giovanni Scambia |
| author_facet | Stefano Lello Anna Capozzi Giovanni Scambia |
| author_sort | Stefano Lello |
| collection | DOAJ |
| description | The tissue-selective estrogen complex (TSEC) pairs conjugated estrogens (CE) with a selective estrogen receptor modulator (SERM), bazedoxifene acetate (BZA). A 2-year treatment with the TSEC improved vasomotor symptoms, quality of life, and vaginal atrophy in healthy postmenopausal women. In addition, the TSEC prevented vertebral and hip bone loss without increasing mammographic density, breast tenderness, the risk of myocardial infarction, stroke, or venous thromboembolism. Finally, the BZA 20 mg/CE 0.45 mg dose did not increase the risk of endometrial hyperplasia. Based on these findings, the TSEC can be considered as a first-line treatment for symptomatic postmenopausal women. |
| format | Article |
| id | doaj-art-171480f40a7248eeb15d7a4ed3d9356b |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-171480f40a7248eeb15d7a4ed3d9356b2025-02-03T01:11:08ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/50647255064725The Tissue-Selective Estrogen Complex (Bazedoxifene/Conjugated Estrogens) for the Treatment of MenopauseStefano Lello0Anna Capozzi1Giovanni Scambia2Department of Woman and Child Health, Policlinico Gemelli Foundation, Largo Agostino Gemelli, Roma, ItalyDepartment of Woman and Child Health, Policlinico Gemelli Foundation, Largo Agostino Gemelli, Roma, ItalyDepartment of Woman and Child Health, Policlinico Gemelli Foundation, Largo Agostino Gemelli, Roma, ItalyThe tissue-selective estrogen complex (TSEC) pairs conjugated estrogens (CE) with a selective estrogen receptor modulator (SERM), bazedoxifene acetate (BZA). A 2-year treatment with the TSEC improved vasomotor symptoms, quality of life, and vaginal atrophy in healthy postmenopausal women. In addition, the TSEC prevented vertebral and hip bone loss without increasing mammographic density, breast tenderness, the risk of myocardial infarction, stroke, or venous thromboembolism. Finally, the BZA 20 mg/CE 0.45 mg dose did not increase the risk of endometrial hyperplasia. Based on these findings, the TSEC can be considered as a first-line treatment for symptomatic postmenopausal women.http://dx.doi.org/10.1155/2017/5064725 |
| spellingShingle | Stefano Lello Anna Capozzi Giovanni Scambia The Tissue-Selective Estrogen Complex (Bazedoxifene/Conjugated Estrogens) for the Treatment of Menopause International Journal of Endocrinology |
| title | The Tissue-Selective Estrogen Complex (Bazedoxifene/Conjugated Estrogens) for the Treatment of Menopause |
| title_full | The Tissue-Selective Estrogen Complex (Bazedoxifene/Conjugated Estrogens) for the Treatment of Menopause |
| title_fullStr | The Tissue-Selective Estrogen Complex (Bazedoxifene/Conjugated Estrogens) for the Treatment of Menopause |
| title_full_unstemmed | The Tissue-Selective Estrogen Complex (Bazedoxifene/Conjugated Estrogens) for the Treatment of Menopause |
| title_short | The Tissue-Selective Estrogen Complex (Bazedoxifene/Conjugated Estrogens) for the Treatment of Menopause |
| title_sort | tissue selective estrogen complex bazedoxifene conjugated estrogens for the treatment of menopause |
| url | http://dx.doi.org/10.1155/2017/5064725 |
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