Genetic Regulation of Maternal Oxytocin Response and Its Influences on Maternal Behavior
We interrogated the genetic modulation of maternal oxytocin response and its association with maternal behavior using genetic risk scores within the oxytocin receptor (OXTR) gene. We identified a novel SNP, rs968389, to be significantly associated with maternal oxytocin response after a challenging...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/5740365 |
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| _version_ | 1832557149028352000 |
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| author | Divya Mehta Valsamma Eapen Jane Kohlhoff Antonio Mendoza Diaz Bryanne Barnett Derrick Silove Mark R. Dadds |
| author_facet | Divya Mehta Valsamma Eapen Jane Kohlhoff Antonio Mendoza Diaz Bryanne Barnett Derrick Silove Mark R. Dadds |
| author_sort | Divya Mehta |
| collection | DOAJ |
| description | We interrogated the genetic modulation of maternal oxytocin response and its association with maternal behavior using genetic risk scores within the oxytocin receptor (OXTR) gene. We identified a novel SNP, rs968389, to be significantly associated with maternal oxytocin response after a challenging mother-infant interaction task (Still Face Paradigm) and maternal separation anxiety from the infant. Performing a multiallelic analysis across OXTR by calculating a cumulative genetic risk score revealed a significant gene-by-environment (G×E) interaction, with OXTR genetic risk score interacting with adult separation anxiety to modulate levels of maternal sensitivity. Mothers with higher OXTR genetic risk score and adult separation anxiety showed significantly reduced levels of maternal sensitivity during free play with the infant. The same G×E interaction was also observed for the extended OXTR cumulative genetic risk score that included rs968389. Moreover, the extended cumulative OXTR genetic risk score itself was found to be significantly associated with maternal separation anxiety as it specifically relates to the infant. Our results suggest a complex montage of individual and synergistic genetic mediators of maternal behavior. These findings add to specific knowledge about genetic regulation of maternal oxytocin response in relation to maternal adjustment and infant bonding through the first few months of life. |
| format | Article |
| id | doaj-art-17133ea61c0649b7b4a4218a0c9ec804 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-17133ea61c0649b7b4a4218a0c9ec8042025-02-03T05:43:32ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/57403655740365Genetic Regulation of Maternal Oxytocin Response and Its Influences on Maternal BehaviorDivya Mehta0Valsamma Eapen1Jane Kohlhoff2Antonio Mendoza Diaz3Bryanne Barnett4Derrick Silove5Mark R. Dadds6School of Psychology and Counseling, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, AustraliaSchool of Psychiatry, University of New South Wales, Sydney, NSW, AustraliaSchool of Psychiatry, University of New South Wales, Sydney, NSW, AustraliaSydney Child Behaviour Research Clinic, School of Psychology, University of Sydney, Sydney, NSW, AustraliaSchool of Psychiatry, University of New South Wales, Sydney, NSW, AustraliaSchool of Psychiatry, University of New South Wales, Sydney, NSW, AustraliaSydney Child Behaviour Research Clinic, School of Psychology, University of Sydney, Sydney, NSW, AustraliaWe interrogated the genetic modulation of maternal oxytocin response and its association with maternal behavior using genetic risk scores within the oxytocin receptor (OXTR) gene. We identified a novel SNP, rs968389, to be significantly associated with maternal oxytocin response after a challenging mother-infant interaction task (Still Face Paradigm) and maternal separation anxiety from the infant. Performing a multiallelic analysis across OXTR by calculating a cumulative genetic risk score revealed a significant gene-by-environment (G×E) interaction, with OXTR genetic risk score interacting with adult separation anxiety to modulate levels of maternal sensitivity. Mothers with higher OXTR genetic risk score and adult separation anxiety showed significantly reduced levels of maternal sensitivity during free play with the infant. The same G×E interaction was also observed for the extended OXTR cumulative genetic risk score that included rs968389. Moreover, the extended cumulative OXTR genetic risk score itself was found to be significantly associated with maternal separation anxiety as it specifically relates to the infant. Our results suggest a complex montage of individual and synergistic genetic mediators of maternal behavior. These findings add to specific knowledge about genetic regulation of maternal oxytocin response in relation to maternal adjustment and infant bonding through the first few months of life.http://dx.doi.org/10.1155/2016/5740365 |
| spellingShingle | Divya Mehta Valsamma Eapen Jane Kohlhoff Antonio Mendoza Diaz Bryanne Barnett Derrick Silove Mark R. Dadds Genetic Regulation of Maternal Oxytocin Response and Its Influences on Maternal Behavior Neural Plasticity |
| title | Genetic Regulation of Maternal Oxytocin Response and Its Influences on Maternal Behavior |
| title_full | Genetic Regulation of Maternal Oxytocin Response and Its Influences on Maternal Behavior |
| title_fullStr | Genetic Regulation of Maternal Oxytocin Response and Its Influences on Maternal Behavior |
| title_full_unstemmed | Genetic Regulation of Maternal Oxytocin Response and Its Influences on Maternal Behavior |
| title_short | Genetic Regulation of Maternal Oxytocin Response and Its Influences on Maternal Behavior |
| title_sort | genetic regulation of maternal oxytocin response and its influences on maternal behavior |
| url | http://dx.doi.org/10.1155/2016/5740365 |
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