Higher intakes of lysine, threonine and valine are inversely associated with non-alcoholic fatty liver disease risk: A community-based case-control study in the Chinese elderly
The associations of individual amino acid with non-alcoholic fatty liver disease (NAFLD) risk remained unclear. The present study aimed to investigate the associations between the two in the Chinese elderly. Methods: A community-based health check-up program was conducted in Qingdao, China. NAFLD wa...
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| Format: | Article |
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Tsinghua University Press
2024-01-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023001337 |
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| author | Xueqi Li Wenjun Ma Ting Yang Chong Wang Wei Zhang Hui Li Ting Zhao Xiaofei Guo |
| author_facet | Xueqi Li Wenjun Ma Ting Yang Chong Wang Wei Zhang Hui Li Ting Zhao Xiaofei Guo |
| author_sort | Xueqi Li |
| collection | DOAJ |
| description | The associations of individual amino acid with non-alcoholic fatty liver disease (NAFLD) risk remained unclear. The present study aimed to investigate the associations between the two in the Chinese elderly. Methods: A community-based health check-up program was conducted in Qingdao, China. NAFLD was diagnosed by ultrasonography accompanied by epidemiological investigation. The dietary intakes of amino acids were investigated with 3-day, 24-h dietary records and calculated by Nutrition Calculator software. Restricted cubic spline model was used to evaluate a nonlinear relationship between amino acid intake and NAFLD risk. Results: 400 NAFLD subjects were identified, and 400 participants were randomly selected as controls and matched by gender and age (± 3 years) Dose-response analysis showed that 1 000 mg increment of aromatic amino acids (AAAs) was associated with reduced 16 % risk of NAFLD. Dietary increments of 750 mg/d threonine, 950 mg/d valine, or 1 700 mg/d lysine were associated with a 20 % reduction in the NAFLD risk (all P for linearity < 0.05). Conclusion: The present study demonstrated that the dietary increases in milk, eggs and deep-sea fish, which are rich in the amino acids, might contribute to protecting against NAFLD in the elderly. |
| format | Article |
| id | doaj-art-170b51577ab04784ab65eb5f8207860d |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-170b51577ab04784ab65eb5f8207860d2025-02-03T06:57:18ZengTsinghua University PressFood Science and Human Wellness2213-45302024-01-01131191197Higher intakes of lysine, threonine and valine are inversely associated with non-alcoholic fatty liver disease risk: A community-based case-control study in the Chinese elderlyXueqi Li0Wenjun Ma1Ting Yang2Chong Wang3Wei Zhang4Hui Li5Ting Zhao6Xiaofei Guo7Institute of Nutrition & Health, School of Public Health, Qingdao University, Qingdao 260071, ChinaInstitute of Nutrition & Health, School of Public Health, Qingdao University, Qingdao 260071, ChinaInstitute of Nutrition & Health, School of Public Health, Qingdao University, Qingdao 260071, ChinaInstitute of Nutrition & Health, School of Public Health, Qingdao University, Qingdao 260071, ChinaAffiliated Hospital of Qingdao University, Qingdao 260071, ChinaAffiliated Hospital of Qingdao University, Qingdao 260071, ChinaAffiliated Hospital of Qingdao University, Qingdao 260071, ChinaInstitute of Nutrition & Health, School of Public Health, Qingdao University, Qingdao 260071, China; Corresponding author at: Institute of Nutrition & Health, Qingdao University, Qingdao 260071, China.The associations of individual amino acid with non-alcoholic fatty liver disease (NAFLD) risk remained unclear. The present study aimed to investigate the associations between the two in the Chinese elderly. Methods: A community-based health check-up program was conducted in Qingdao, China. NAFLD was diagnosed by ultrasonography accompanied by epidemiological investigation. The dietary intakes of amino acids were investigated with 3-day, 24-h dietary records and calculated by Nutrition Calculator software. Restricted cubic spline model was used to evaluate a nonlinear relationship between amino acid intake and NAFLD risk. Results: 400 NAFLD subjects were identified, and 400 participants were randomly selected as controls and matched by gender and age (± 3 years) Dose-response analysis showed that 1 000 mg increment of aromatic amino acids (AAAs) was associated with reduced 16 % risk of NAFLD. Dietary increments of 750 mg/d threonine, 950 mg/d valine, or 1 700 mg/d lysine were associated with a 20 % reduction in the NAFLD risk (all P for linearity < 0.05). Conclusion: The present study demonstrated that the dietary increases in milk, eggs and deep-sea fish, which are rich in the amino acids, might contribute to protecting against NAFLD in the elderly.http://www.sciencedirect.com/science/article/pii/S2213453023001337Amino acidNon-alcoholic fatty liver diseaseSenior citizenDose-response analysis |
| spellingShingle | Xueqi Li Wenjun Ma Ting Yang Chong Wang Wei Zhang Hui Li Ting Zhao Xiaofei Guo Higher intakes of lysine, threonine and valine are inversely associated with non-alcoholic fatty liver disease risk: A community-based case-control study in the Chinese elderly Food Science and Human Wellness Amino acid Non-alcoholic fatty liver disease Senior citizen Dose-response analysis |
| title | Higher intakes of lysine, threonine and valine are inversely associated with non-alcoholic fatty liver disease risk: A community-based case-control study in the Chinese elderly |
| title_full | Higher intakes of lysine, threonine and valine are inversely associated with non-alcoholic fatty liver disease risk: A community-based case-control study in the Chinese elderly |
| title_fullStr | Higher intakes of lysine, threonine and valine are inversely associated with non-alcoholic fatty liver disease risk: A community-based case-control study in the Chinese elderly |
| title_full_unstemmed | Higher intakes of lysine, threonine and valine are inversely associated with non-alcoholic fatty liver disease risk: A community-based case-control study in the Chinese elderly |
| title_short | Higher intakes of lysine, threonine and valine are inversely associated with non-alcoholic fatty liver disease risk: A community-based case-control study in the Chinese elderly |
| title_sort | higher intakes of lysine threonine and valine are inversely associated with non alcoholic fatty liver disease risk a community based case control study in the chinese elderly |
| topic | Amino acid Non-alcoholic fatty liver disease Senior citizen Dose-response analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023001337 |
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