Diversity of mast cell subpopulations in the tumor microenvironment of colorectal cancer and their prognostic implications

Diversity of mast cell subpopulations in the tumor microenvironment of colorectal cancer and their prognostic implications

Abstract Background Colorectal cancer (CRC) is one of the most common and deadly malignancies worldwide, with a particularly low 5-year survival rate in advanced patients. Immune cells in the tumor microenvironment, especially mast cells, play crucial roles in tumor initiation and progression. Howev...

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Bibliographic Details
Main Authors: Tianyu Qiao, Chao Ding, Songtao Yu, Wenyang Li, Yonghou Zhao, Guiyu Wang
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Colorectal cancer
Tumor microenvironment
Mast cells
Single-cell RNA sequencing
Prognosis
Immunotherapy
Online Access:https://doi.org/10.1007/s00262-025-04119-8
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