PLCH1 overexpression promotes breast cancer progression and predicts poor prognosis through the ERK1/2-EGR1 axis

PLCH1 overexpression promotes breast cancer progression and predicts poor prognosis through the ERK1/2-EGR1 axis

BackgroundPhospholipase C η1 (PLCH1), a member of the phospholipase C superfamily, has been implicated in the development of multiple cancers. However, its specific role in breast cancer progression, its association with clinicopathological features, and its prognostic significance remain unclear.Me...

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Bibliographic Details
Main Authors: Jing Li, Fenge Jiang, Congcong Wang, Ping Sun, Lei Song, Jiannan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
breast cancer
PLCH1
apoptosis
cell cycle
ERK1/2
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1577114/full
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