Brucella osteoarthritis: recent progress and future directions
Brucellosis is a common zoonosis, and Brucella osteoarthritis is the most common chronic complication of brucellosis. Development of brucellosis osteoarthritis involves multiple organs, tissues, and cells. Brucella grows and multiplies in intrinsic cells of the skeleton, including osteoblasts, osteo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1522537/full |
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| author | Jinlei Chen Jinlei Chen Jinlei Chen Jinlei Chen Jinlei Chen Feijie Zhi Feijie Zhi Feijie Zhi Guanghai Zhao Guanghai Zhao Mengru Su Mengru Su Mengru Su Hao Geng Hao Geng Hao Geng Wei Song Wei Song Yuefeng Chu Yuefeng Chu Yuefeng Chu Haihong Zhang Haihong Zhang |
| author_facet | Jinlei Chen Jinlei Chen Jinlei Chen Jinlei Chen Jinlei Chen Feijie Zhi Feijie Zhi Feijie Zhi Guanghai Zhao Guanghai Zhao Mengru Su Mengru Su Mengru Su Hao Geng Hao Geng Hao Geng Wei Song Wei Song Yuefeng Chu Yuefeng Chu Yuefeng Chu Haihong Zhang Haihong Zhang |
| author_sort | Jinlei Chen |
| collection | DOAJ |
| description | Brucellosis is a common zoonosis, and Brucella osteoarthritis is the most common chronic complication of brucellosis. Development of brucellosis osteoarthritis involves multiple organs, tissues, and cells. Brucella grows and multiplies in intrinsic cells of the skeleton, including osteoblasts, osteocyte and osteoclasts, which results in sustained release of bacteria that leads to exacerbation of the immune response. Concurrently, activation of the immune system caused by invasion with Brucella may affect the dynamic balance of the skeleton. A variety of in vitro and in vivo models have been employed to study Brucella osteoarthritis, such as using bone marrow-derived macrophages to establish cell models and mice to develop animal models of Brucella osteoarthritis. However, limited studies on the molecular pathological mechanisms of Brucella osteoarthritis have been performed and inadequate animal models have been developed due to the challenging parameters of Brucella research. This paper reviews recent advances in the clinical features, molecular pathological mechanisms, and animal models of Brucella osteoarticular infections. This review underscores the complexity of the pathogenesis of Brucella osteoarticular infections and highlights inflammation as a contributing factor to bone loss caused by Brucella. Additionally, the significant proliferation of Brucella in skeletal resident cells also is an important factor leading to bone loss. A deeper understanding of the molecular pathological mechanism of Brucella osteoarthrosis and their animal models could provide robust support for the prevention and treatment of Brucella osteoarticular disease. |
| format | Article |
| id | doaj-art-16e5c218afe84f39b3ab3aff28980305 |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-16e5c218afe84f39b3ab3aff289803052025-02-04T08:57:46ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-02-011610.3389/fmicb.2025.15225371522537Brucella osteoarthritis: recent progress and future directionsJinlei Chen0Jinlei Chen1Jinlei Chen2Jinlei Chen3Jinlei Chen4Feijie Zhi5Feijie Zhi6Feijie Zhi7Guanghai Zhao8Guanghai Zhao9Mengru Su10Mengru Su11Mengru Su12Hao Geng13Hao Geng14Hao Geng15Wei Song16Wei Song17Yuefeng Chu18Yuefeng Chu19Yuefeng Chu20Haihong Zhang21Haihong Zhang22Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, ChinaOrthopaedics Key Laboratory of Gansu Province, Lanzhou, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou University, Lanzhou, ChinaGansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, ChinaKey Laboratory of Veterinary Etiological Biology, Key Laboratory of Ruminant Disease Prevention and Control (West), Ministry of Agricultural and Rural Affairs, Lanzhou, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou University, Lanzhou, ChinaGansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, ChinaKey Laboratory of Veterinary Etiological Biology, Key Laboratory of Ruminant Disease Prevention and Control (West), Ministry of Agricultural and Rural Affairs, Lanzhou, ChinaDepartment of Orthopedics, Lanzhou University Second Hospital, Lanzhou, ChinaOrthopaedics Key Laboratory of Gansu Province, Lanzhou, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou University, Lanzhou, ChinaGansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, ChinaKey Laboratory of Veterinary Etiological Biology, Key Laboratory of Ruminant Disease Prevention and Control (West), Ministry of Agricultural and Rural Affairs, Lanzhou, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou University, Lanzhou, ChinaGansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, ChinaKey Laboratory of Veterinary Etiological Biology, Key Laboratory of Ruminant Disease Prevention and Control (West), Ministry of Agricultural and Rural Affairs, Lanzhou, ChinaDepartment of Orthopedics, Lanzhou University Second Hospital, Lanzhou, ChinaOrthopaedics Key Laboratory of Gansu Province, Lanzhou, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou University, Lanzhou, ChinaGansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, ChinaKey Laboratory of Veterinary Etiological Biology, Key Laboratory of Ruminant Disease Prevention and Control (West), Ministry of Agricultural and Rural Affairs, Lanzhou, ChinaDepartment of Orthopedics, Lanzhou University Second Hospital, Lanzhou, ChinaOrthopaedics Key Laboratory of Gansu Province, Lanzhou, ChinaBrucellosis is a common zoonosis, and Brucella osteoarthritis is the most common chronic complication of brucellosis. Development of brucellosis osteoarthritis involves multiple organs, tissues, and cells. Brucella grows and multiplies in intrinsic cells of the skeleton, including osteoblasts, osteocyte and osteoclasts, which results in sustained release of bacteria that leads to exacerbation of the immune response. Concurrently, activation of the immune system caused by invasion with Brucella may affect the dynamic balance of the skeleton. A variety of in vitro and in vivo models have been employed to study Brucella osteoarthritis, such as using bone marrow-derived macrophages to establish cell models and mice to develop animal models of Brucella osteoarthritis. However, limited studies on the molecular pathological mechanisms of Brucella osteoarthritis have been performed and inadequate animal models have been developed due to the challenging parameters of Brucella research. This paper reviews recent advances in the clinical features, molecular pathological mechanisms, and animal models of Brucella osteoarticular infections. This review underscores the complexity of the pathogenesis of Brucella osteoarticular infections and highlights inflammation as a contributing factor to bone loss caused by Brucella. Additionally, the significant proliferation of Brucella in skeletal resident cells also is an important factor leading to bone loss. A deeper understanding of the molecular pathological mechanism of Brucella osteoarthrosis and their animal models could provide robust support for the prevention and treatment of Brucella osteoarticular disease.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1522537/fullosteoarthritisBrucellaanimal modelspathophysiological mechanismsinflammation |
| spellingShingle | Jinlei Chen Jinlei Chen Jinlei Chen Jinlei Chen Jinlei Chen Feijie Zhi Feijie Zhi Feijie Zhi Guanghai Zhao Guanghai Zhao Mengru Su Mengru Su Mengru Su Hao Geng Hao Geng Hao Geng Wei Song Wei Song Yuefeng Chu Yuefeng Chu Yuefeng Chu Haihong Zhang Haihong Zhang Brucella osteoarthritis: recent progress and future directions Frontiers in Microbiology osteoarthritis Brucella animal models pathophysiological mechanisms inflammation |
| title | Brucella osteoarthritis: recent progress and future directions |
| title_full | Brucella osteoarthritis: recent progress and future directions |
| title_fullStr | Brucella osteoarthritis: recent progress and future directions |
| title_full_unstemmed | Brucella osteoarthritis: recent progress and future directions |
| title_short | Brucella osteoarthritis: recent progress and future directions |
| title_sort | brucella osteoarthritis recent progress and future directions |
| topic | osteoarthritis Brucella animal models pathophysiological mechanisms inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1522537/full |
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