Thyrotoxic Periodic Paralysis: Case Reports and an Up-to-Date Review of the Literature
Objectives. To describe 2 cases of thyrotoxic periodic paralysis. Methods. We report of 2 cases of thyrotoxic periodic paralysis in 2 individuals from 2 different backgrounds with emphasis on their presentation and treatment. We also conducted a literature search to put together an update review of...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2011/867475 |
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| author | Abbi Lulsegged Christina Wlodek Michela Rossi |
| author_facet | Abbi Lulsegged Christina Wlodek Michela Rossi |
| author_sort | Abbi Lulsegged |
| collection | DOAJ |
| description | Objectives. To describe 2 cases of thyrotoxic periodic paralysis. Methods. We report of 2 cases of thyrotoxic periodic paralysis in 2 individuals from 2 different backgrounds with emphasis on their presentation and treatment. We also conducted a literature search to put together an update review of thyrotoxic periodic paralysis. Results. A 47-year-old Chinese and 28-year-old Caucasian male presented with profound yet reversible weakness associated with hypokalemia on admission bloods and thyrotoxicosis. Both were given definitive therapy to prevent recurrence of attacks with any future relapse of thyrotoxicosis. Conclusion. Thyrotoxic periodic paralysis (TPP) is a rare but potentially serious complication of thyrotoxicosis resulting in temporary but severe muscle weakness. Recent discovery of a novel mutation in the KCNJ18 gene which codes for an inwardly rectifying potassium channel and is controlled by thyroid hormones may provide greater insight into the pathogenesis of TPP. |
| format | Article |
| id | doaj-art-16e2e8d66f624143b7870a41d515032f |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-16e2e8d66f624143b7870a41d515032f2025-02-03T05:53:36ZengWileyCase Reports in Endocrinology2090-65012090-651X2011-01-01201110.1155/2011/867475867475Thyrotoxic Periodic Paralysis: Case Reports and an Up-to-Date Review of the LiteratureAbbi Lulsegged0Christina Wlodek1Michela Rossi2Department of Endocrinology, South London HealthCare NHS Trust, Orpington Hospital, Sevenoaks Road, Orpington BR6 9JU, UKDepartment of Endocrinology, South London HealthCare NHS Trust, Orpington Hospital, Sevenoaks Road, Orpington BR6 9JU, UKDepartment of Endocrinology, Whittington NHS Trust Hospital, London N19 5NF, UKObjectives. To describe 2 cases of thyrotoxic periodic paralysis. Methods. We report of 2 cases of thyrotoxic periodic paralysis in 2 individuals from 2 different backgrounds with emphasis on their presentation and treatment. We also conducted a literature search to put together an update review of thyrotoxic periodic paralysis. Results. A 47-year-old Chinese and 28-year-old Caucasian male presented with profound yet reversible weakness associated with hypokalemia on admission bloods and thyrotoxicosis. Both were given definitive therapy to prevent recurrence of attacks with any future relapse of thyrotoxicosis. Conclusion. Thyrotoxic periodic paralysis (TPP) is a rare but potentially serious complication of thyrotoxicosis resulting in temporary but severe muscle weakness. Recent discovery of a novel mutation in the KCNJ18 gene which codes for an inwardly rectifying potassium channel and is controlled by thyroid hormones may provide greater insight into the pathogenesis of TPP.http://dx.doi.org/10.1155/2011/867475 |
| spellingShingle | Abbi Lulsegged Christina Wlodek Michela Rossi Thyrotoxic Periodic Paralysis: Case Reports and an Up-to-Date Review of the Literature Case Reports in Endocrinology |
| title | Thyrotoxic Periodic Paralysis: Case Reports and an Up-to-Date Review of the Literature |
| title_full | Thyrotoxic Periodic Paralysis: Case Reports and an Up-to-Date Review of the Literature |
| title_fullStr | Thyrotoxic Periodic Paralysis: Case Reports and an Up-to-Date Review of the Literature |
| title_full_unstemmed | Thyrotoxic Periodic Paralysis: Case Reports and an Up-to-Date Review of the Literature |
| title_short | Thyrotoxic Periodic Paralysis: Case Reports and an Up-to-Date Review of the Literature |
| title_sort | thyrotoxic periodic paralysis case reports and an up to date review of the literature |
| url | http://dx.doi.org/10.1155/2011/867475 |
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