Association between abnormal default mode network homogeneity and sleep disturbances in major depressive disorder
Background Sleep disturbance is a common comorbidity of major depressive disorder (MDD). However, network homogeneity (NH) changes of the default mode network (DMN) in MDD with sleep disturbances are unclear.Aims The purpose of this study was to probe the abnormal NH in the DMN in MDD with sleep dis...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-04-01
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| Series: | General Psychiatry |
| Online Access: | https://gpsych.bmj.com/content/37/2/e101371.full |
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| author | Ping Li Feng Liu Jingping Zhao Muzhi Huang Yangpan Ou Huabing Li Bing Lang Wenbin Guo |
| author_facet | Ping Li Feng Liu Jingping Zhao Muzhi Huang Yangpan Ou Huabing Li Bing Lang Wenbin Guo |
| author_sort | Ping Li |
| collection | DOAJ |
| description | Background Sleep disturbance is a common comorbidity of major depressive disorder (MDD). However, network homogeneity (NH) changes of the default mode network (DMN) in MDD with sleep disturbances are unclear.Aims The purpose of this study was to probe the abnormal NH in the DMN in MDD with sleep disturbances and to reveal the differences between MDD with or without sleep disturbances.Methods Twenty-four patients with MDD and sleep disturbances (Pa_s), 33 patients with MDD without sleep disturbances (Pa_ns) and 32 healthy controls (HCs) were recruited in this study. Resting-state functional imaging data were analysed using NH.Results Compared with Pa_ns and HCs, Pa_s showed decreased NH in the left superior medial prefrontal cortex and increased NH in the right precuneus. There was a negative correlation between NH in the left superior medial prefrontal cortex and sleep disturbances (r=−0.42, p=0.001) as well as a positive correlation between NH in the right precuneus and sleep disturbances (r=0.41, p=0.002) in patients with MDD.Conclusions MDD with sleep disturbances is associated with abnormal NH in the DMN, which could differentiate pa_s from pa_ns. The DMN may play a crucial role in the neurobiological mechanisms of MDD with sleep disturbances. |
| format | Article |
| id | doaj-art-16d9d6df34ba47f78d12df9e33e14f51 |
| institution | Kabale University |
| issn | 2517-729X |
| language | English |
| publishDate | 2024-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | General Psychiatry |
| spelling | doaj-art-16d9d6df34ba47f78d12df9e33e14f512025-01-29T17:00:10ZengBMJ Publishing GroupGeneral Psychiatry2517-729X2024-04-0137210.1136/gpsych-2023-101371Association between abnormal default mode network homogeneity and sleep disturbances in major depressive disorderPing Li0Feng Liu1Jingping Zhao2Muzhi Huang3Yangpan Ou4Huabing Li5Bing Lang6Wenbin Guo7Xiamen Key Laboratory of Reproduction and Genetics, Xiamen, ChinaNational Clinical Research Center for Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China1 Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China1 Department of Psychiatry, The Second Xiangya Hospital of Central South University National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, Changsha, Hunan, China1 Department of Psychiatry, The Second Xiangya Hospital of Central South University National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, Changsha, Hunan, China7 Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China1 Department of Psychiatry, The Second Xiangya Hospital of Central South University National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, Changsha, Hunan, China1 Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaBackground Sleep disturbance is a common comorbidity of major depressive disorder (MDD). However, network homogeneity (NH) changes of the default mode network (DMN) in MDD with sleep disturbances are unclear.Aims The purpose of this study was to probe the abnormal NH in the DMN in MDD with sleep disturbances and to reveal the differences between MDD with or without sleep disturbances.Methods Twenty-four patients with MDD and sleep disturbances (Pa_s), 33 patients with MDD without sleep disturbances (Pa_ns) and 32 healthy controls (HCs) were recruited in this study. Resting-state functional imaging data were analysed using NH.Results Compared with Pa_ns and HCs, Pa_s showed decreased NH in the left superior medial prefrontal cortex and increased NH in the right precuneus. There was a negative correlation between NH in the left superior medial prefrontal cortex and sleep disturbances (r=−0.42, p=0.001) as well as a positive correlation between NH in the right precuneus and sleep disturbances (r=0.41, p=0.002) in patients with MDD.Conclusions MDD with sleep disturbances is associated with abnormal NH in the DMN, which could differentiate pa_s from pa_ns. The DMN may play a crucial role in the neurobiological mechanisms of MDD with sleep disturbances.https://gpsych.bmj.com/content/37/2/e101371.full |
| spellingShingle | Ping Li Feng Liu Jingping Zhao Muzhi Huang Yangpan Ou Huabing Li Bing Lang Wenbin Guo Association between abnormal default mode network homogeneity and sleep disturbances in major depressive disorder General Psychiatry |
| title | Association between abnormal default mode network homogeneity and sleep disturbances in major depressive disorder |
| title_full | Association between abnormal default mode network homogeneity and sleep disturbances in major depressive disorder |
| title_fullStr | Association between abnormal default mode network homogeneity and sleep disturbances in major depressive disorder |
| title_full_unstemmed | Association between abnormal default mode network homogeneity and sleep disturbances in major depressive disorder |
| title_short | Association between abnormal default mode network homogeneity and sleep disturbances in major depressive disorder |
| title_sort | association between abnormal default mode network homogeneity and sleep disturbances in major depressive disorder |
| url | https://gpsych.bmj.com/content/37/2/e101371.full |
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