Clonorchis sinensis extracellular vesicles associated with Csi-let-7a-5p activate pro-inflammatory macrophages to induce biliary injury.

Clonorchis sinensis extracellular vesicles associated with Csi-let-7a-5p activate pro-inflammatory macrophages to induce biliary injury.

During Clonorchis sinensis (C. sinensis) infection, pro-inflammatory macrophages (M1 macrophages) are highly activated, yet their role in the disease remains poorly understood. Previous studies have demonstrated that extracellular vesicles from C. sinensis (CsEVs) can activate these macrophages, and...

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Bibliographic Details
Main Authors: Beibei Zhang, Xing Li, Qian-Yang Zhou, Chen Zhang, Zheng-Rui Bian, Xin-Xin Ren, Qian Yu, Hui Hua, Zhihua Jiang, Bo Zhang, Xiang-Yang Li, Mu-Xin Chen, Kui-Yang Zheng, Chao Yan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-05-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0013080
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