HMG-CoA Reductase Inhibitors from Monascus-Fermented Rice
Seven compounds were isolated from Monascus-fermented rice by column chromatography with silica gel and semiprep HPLC. Their structures were elucidated by extensive spectroscopic methods. All compounds displayed HMG-CoA reductase inhibitory potential, among them compound 7 exhibited strong inhibitio...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/872056 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549771863130112 |
|---|---|
| author | Xuemei Li Chunli Liu Zhenwen Duan Shuren Guo |
| author_facet | Xuemei Li Chunli Liu Zhenwen Duan Shuren Guo |
| author_sort | Xuemei Li |
| collection | DOAJ |
| description | Seven compounds were isolated from Monascus-fermented rice by column chromatography with silica gel and semiprep HPLC. Their structures were elucidated by extensive spectroscopic methods. All compounds displayed HMG-CoA reductase inhibitory potential, among them compound 7 exhibited strong inhibition with IC50 value comparable with lovastatin. In this study, two compounds (1 and 2) were obtained from natural source for the first time. |
| format | Article |
| id | doaj-art-16cc59c75cf3413c9a07737743d3b965 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-16cc59c75cf3413c9a07737743d3b9652025-02-03T06:08:30ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/872056872056HMG-CoA Reductase Inhibitors from Monascus-Fermented RiceXuemei Li0Chunli Liu1Zhenwen Duan2Shuren Guo3Beijing Peking University WBL Biotechnology Co., Ltd., Beijing 100094, ChinaBeijing Peking University WBL Biotechnology Co., Ltd., Beijing 100094, ChinaBeijing Peking University WBL Biotechnology Co., Ltd., Beijing 100094, ChinaBeijing Peking University WBL Biotechnology Co., Ltd., Beijing 100094, ChinaSeven compounds were isolated from Monascus-fermented rice by column chromatography with silica gel and semiprep HPLC. Their structures were elucidated by extensive spectroscopic methods. All compounds displayed HMG-CoA reductase inhibitory potential, among them compound 7 exhibited strong inhibition with IC50 value comparable with lovastatin. In this study, two compounds (1 and 2) were obtained from natural source for the first time.http://dx.doi.org/10.1155/2013/872056 |
| spellingShingle | Xuemei Li Chunli Liu Zhenwen Duan Shuren Guo HMG-CoA Reductase Inhibitors from Monascus-Fermented Rice Journal of Chemistry |
| title | HMG-CoA Reductase Inhibitors from Monascus-Fermented Rice |
| title_full | HMG-CoA Reductase Inhibitors from Monascus-Fermented Rice |
| title_fullStr | HMG-CoA Reductase Inhibitors from Monascus-Fermented Rice |
| title_full_unstemmed | HMG-CoA Reductase Inhibitors from Monascus-Fermented Rice |
| title_short | HMG-CoA Reductase Inhibitors from Monascus-Fermented Rice |
| title_sort | hmg coa reductase inhibitors from monascus fermented rice |
| url | http://dx.doi.org/10.1155/2013/872056 |
| work_keys_str_mv | AT xuemeili hmgcoareductaseinhibitorsfrommonascusfermentedrice AT chunliliu hmgcoareductaseinhibitorsfrommonascusfermentedrice AT zhenwenduan hmgcoareductaseinhibitorsfrommonascusfermentedrice AT shurenguo hmgcoareductaseinhibitorsfrommonascusfermentedrice |