Normative Values of Brainstem Auditory-Evoked Responses in Sheep
<b>Background:</b> The brainstem auditory-evoked response (BAER) is an established electrophysiological measure of neural activity from the auditory nerve up to the brain stem. The BAER is used to diagnose abnormalities in auditory pathways and in neurophysiological human and animal rese...
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2025-01-01
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| author | Katharina Suntinger Adrian Dalbert Lukas Prochazka Milena Tegelkamp Peter Kronen Karina Klein Christof Röösli Alexander Huber Flurin Pfiffner |
| author_facet | Katharina Suntinger Adrian Dalbert Lukas Prochazka Milena Tegelkamp Peter Kronen Karina Klein Christof Röösli Alexander Huber Flurin Pfiffner |
| author_sort | Katharina Suntinger |
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| description | <b>Background:</b> The brainstem auditory-evoked response (BAER) is an established electrophysiological measure of neural activity from the auditory nerve up to the brain stem. The BAER is used to diagnose abnormalities in auditory pathways and in neurophysiological human and animal research. However, normative data for BAERs in sheep, which represent an adequate large animal model for translational and basic otological research, are lacking. <b>Objective:</b> The aim of this study was to assess the function of the ovine auditory nervous system by determining normative values for the BAER and to compare sheep with human BAER data. <b>Methods:</b> In this retrospective study, BAER data for click stimuli at a range of sound pressure levels (SPLs) were analyzed. A series of 15 samples from six sheep with a mean age of 41.8 months was included. <b>Results:</b> The mean BAER threshold was 45.3 dB SPL. At 100 dB SPL, the mean (±standard deviation, SD) latency of wave V was 4.35 (±0.18) ms, that of wave III was 2.44 (±0.15) ms, and that of wave I was 0.88 (±0.13) ms. At 100 dB SPL, the mean interpeak latency of waves I–III was 1.56 (±0.18) ms, that of waves III–V was 1.91 (±0.16) ms, and that of waves I–V was 3.47 (±0.20) ms. The mean amplitudes at 100 dB SPL were 0.04 (±0.03) µV for wave I, 0.50 (±0.24) µV for wave III, and 0.40 (±0.25) µV for wave V. <b>Conclusions:</b> The normative values for sheep BAERs were reproducible and similar to those of humans. The normative BAER values further support sheep as an adequate animal model for otological research. |
| format | Article |
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| institution | Kabale University |
| issn | 2076-3425 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Brain Sciences |
| spelling | doaj-art-16c35f4eb865447ebacf5a3677d53fb52025-01-24T13:25:52ZengMDPI AGBrain Sciences2076-34252025-01-011516910.3390/brainsci15010069Normative Values of Brainstem Auditory-Evoked Responses in SheepKatharina Suntinger0Adrian Dalbert1Lukas Prochazka2Milena Tegelkamp3Peter Kronen4Karina Klein5Christof Röösli6Alexander Huber7Flurin Pfiffner8Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, 8006 Zurich, SwitzerlandDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, 8006 Zurich, SwitzerlandDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, 8006 Zurich, SwitzerlandMusculoskeletal Research Unit, Vetsuisse Faculty, University of Zurich, 8057 Zurich, SwitzerlandMusculoskeletal Research Unit, Vetsuisse Faculty, University of Zurich, 8057 Zurich, SwitzerlandMusculoskeletal Research Unit, Vetsuisse Faculty, University of Zurich, 8057 Zurich, SwitzerlandDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, 8006 Zurich, SwitzerlandDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, 8006 Zurich, SwitzerlandDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, 8006 Zurich, Switzerland<b>Background:</b> The brainstem auditory-evoked response (BAER) is an established electrophysiological measure of neural activity from the auditory nerve up to the brain stem. The BAER is used to diagnose abnormalities in auditory pathways and in neurophysiological human and animal research. However, normative data for BAERs in sheep, which represent an adequate large animal model for translational and basic otological research, are lacking. <b>Objective:</b> The aim of this study was to assess the function of the ovine auditory nervous system by determining normative values for the BAER and to compare sheep with human BAER data. <b>Methods:</b> In this retrospective study, BAER data for click stimuli at a range of sound pressure levels (SPLs) were analyzed. A series of 15 samples from six sheep with a mean age of 41.8 months was included. <b>Results:</b> The mean BAER threshold was 45.3 dB SPL. At 100 dB SPL, the mean (±standard deviation, SD) latency of wave V was 4.35 (±0.18) ms, that of wave III was 2.44 (±0.15) ms, and that of wave I was 0.88 (±0.13) ms. At 100 dB SPL, the mean interpeak latency of waves I–III was 1.56 (±0.18) ms, that of waves III–V was 1.91 (±0.16) ms, and that of waves I–V was 3.47 (±0.20) ms. The mean amplitudes at 100 dB SPL were 0.04 (±0.03) µV for wave I, 0.50 (±0.24) µV for wave III, and 0.40 (±0.25) µV for wave V. <b>Conclusions:</b> The normative values for sheep BAERs were reproducible and similar to those of humans. The normative BAER values further support sheep as an adequate animal model for otological research.https://www.mdpi.com/2076-3425/15/1/69auditory-evoked potentialsbrainstem auditory-evoked responseotologyovine animal modelsheep |
| spellingShingle | Katharina Suntinger Adrian Dalbert Lukas Prochazka Milena Tegelkamp Peter Kronen Karina Klein Christof Röösli Alexander Huber Flurin Pfiffner Normative Values of Brainstem Auditory-Evoked Responses in Sheep Brain Sciences auditory-evoked potentials brainstem auditory-evoked response otology ovine animal model sheep |
| title | Normative Values of Brainstem Auditory-Evoked Responses in Sheep |
| title_full | Normative Values of Brainstem Auditory-Evoked Responses in Sheep |
| title_fullStr | Normative Values of Brainstem Auditory-Evoked Responses in Sheep |
| title_full_unstemmed | Normative Values of Brainstem Auditory-Evoked Responses in Sheep |
| title_short | Normative Values of Brainstem Auditory-Evoked Responses in Sheep |
| title_sort | normative values of brainstem auditory evoked responses in sheep |
| topic | auditory-evoked potentials brainstem auditory-evoked response otology ovine animal model sheep |
| url | https://www.mdpi.com/2076-3425/15/1/69 |
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