PPAR-δ in Vascular Pathophysiology
Peroxisome proliferator-activated receptors belong to the superfamily of ligand-dependent nuclear receptor transcription factors, which include three subtypes: PPAR-α, β/δ, and γ. PPAR-δ, play important roles in the regulation of cell growth and differentiation as well as tissue wound and repair. Em...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2008/164163 |
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| _version_ | 1832552481602666496 |
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| author | Nanping Wang |
| author_facet | Nanping Wang |
| author_sort | Nanping Wang |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptors belong to the superfamily of ligand-dependent nuclear receptor transcription factors, which include three subtypes: PPAR-α, β/δ, and γ. PPAR-δ, play important roles in the regulation of cell growth and differentiation as well as tissue wound and repair. Emerging evidence has also demonstrated that PPAR-δ is implicated in lipids and glucose metabolism. Most recently, the direct effects of PPAR-δ on cardiovascular processes such as endothelial function and angiogenesis have also been investigated. Therefore, it is suggested that PPAR-δ may have critical roles in cardiovascular pathophysiology and is a potential target for therapeutic intervention of cardiovascular disorders such as atherosclerosis. |
| format | Article |
| id | doaj-art-16bc6cf44000477ba453fba286919269 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-16bc6cf44000477ba453fba2869192692025-02-03T05:58:29ZengWileyPPAR Research1687-47571687-47652008-01-01200810.1155/2008/164163164163PPAR-δ in Vascular PathophysiologyNanping Wang0Laboratory of Vascular Molecular Biology and Bioengineering, Institute of Cardiovascular Science and Diabetes Center, Peking University Health Science Center, Beijing 100191, ChinaPeroxisome proliferator-activated receptors belong to the superfamily of ligand-dependent nuclear receptor transcription factors, which include three subtypes: PPAR-α, β/δ, and γ. PPAR-δ, play important roles in the regulation of cell growth and differentiation as well as tissue wound and repair. Emerging evidence has also demonstrated that PPAR-δ is implicated in lipids and glucose metabolism. Most recently, the direct effects of PPAR-δ on cardiovascular processes such as endothelial function and angiogenesis have also been investigated. Therefore, it is suggested that PPAR-δ may have critical roles in cardiovascular pathophysiology and is a potential target for therapeutic intervention of cardiovascular disorders such as atherosclerosis.http://dx.doi.org/10.1155/2008/164163 |
| spellingShingle | Nanping Wang PPAR-δ in Vascular Pathophysiology PPAR Research |
| title | PPAR-δ in Vascular Pathophysiology |
| title_full | PPAR-δ in Vascular Pathophysiology |
| title_fullStr | PPAR-δ in Vascular Pathophysiology |
| title_full_unstemmed | PPAR-δ in Vascular Pathophysiology |
| title_short | PPAR-δ in Vascular Pathophysiology |
| title_sort | ppar δ in vascular pathophysiology |
| url | http://dx.doi.org/10.1155/2008/164163 |
| work_keys_str_mv | AT nanpingwang ppardinvascularpathophysiology |