Consensus on rapid screening for prodromal Alzheimer’s disease in China
Alzheimer’s disease (AD) is a common cause of dementia, characterised by cerebral amyloid-β deposition, pathological tau and neurodegeneration. The prodromal stage of AD (pAD) refers to patients with mild cognitive impairment (MCI) and evidence of AD’s pathology. At this stage, disease-modifying int...
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| Format: | Article |
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BMJ Publishing Group
2024-02-01
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| Series: | General Psychiatry |
| Online Access: | https://gpsych.bmj.com/content/37/1/e101310.full |
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| author | Yao Lu Ying Wang Jianping Jia Qihao Guo Ya Miao Lin Huang Xiaochun Chen Qinjie Li Fengfeng Pan Liang Cui Tianlu Chen Yatian Li Jingnan Wu |
| author_facet | Yao Lu Ying Wang Jianping Jia Qihao Guo Ya Miao Lin Huang Xiaochun Chen Qinjie Li Fengfeng Pan Liang Cui Tianlu Chen Yatian Li Jingnan Wu |
| author_sort | Yao Lu |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a common cause of dementia, characterised by cerebral amyloid-β deposition, pathological tau and neurodegeneration. The prodromal stage of AD (pAD) refers to patients with mild cognitive impairment (MCI) and evidence of AD’s pathology. At this stage, disease-modifying interventions should be used to prevent the progression to dementia. Given the inherent heterogeneity of MCI, more specific biomarkers are needed to elucidate the underlying AD’s pathology. Although the uses of cerebrospinal fluid and positron emission tomography are widely accepted methods for detecting AD’s pathology, their clinical applications are limited by their high costs and invasiveness, particularly in low-income areas in China. Therefore, to improve the early detection of Alzheimer's disease (AD) pathology through cost-effective screening methods, a panel of 45 neurologists, psychiatrists and gerontologists was invited to establish a formal consensus on the screening of pAD in China. The supportive evidence and grades of recommendations are based on a systematic literature review and focus group discussion. National meetings were held to allow participants to review, vote and provide their expert opinions to reach a consensus. A majority (two-thirds) decision was used for questions for which consensus could not be reached. Recommended screening methods are presented in this publication, including neuropsychological assessment, peripheral biomarkers and brain imaging. In addition, a general workflow for screening pAD in China is established, which will help clinicians identify individuals at high risk and determine therapeutic targets. |
| format | Article |
| id | doaj-art-16ba882e8f2d4f26b240a6de91ba7839 |
| institution | Kabale University |
| issn | 2517-729X |
| language | English |
| publishDate | 2024-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | General Psychiatry |
| spelling | doaj-art-16ba882e8f2d4f26b240a6de91ba78392025-01-29T17:35:10ZengBMJ Publishing GroupGeneral Psychiatry2517-729X2024-02-0137110.1136/gpsych-2023-101310Consensus on rapid screening for prodromal Alzheimer’s disease in ChinaYao Lu0Ying Wang1Jianping Jia2Qihao Guo3Ya Miao4Lin Huang5Xiaochun Chen6Qinjie Li7Fengfeng Pan8Liang Cui9Tianlu Chen10Yatian Li11Jingnan Wu121 Peking University Clinical Research Institute, Peking University First Hospital, Beijing, China1 Department of Nursing, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin, China5 Department of Neurology, National Clinical Research Center for Geriatric Diseases, Beijing, China1 Department of Gerontology, Shanghai Sixth People`s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China1 Department of Gerontology, Shanghai Sixth People`s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China1 Department of Gerontology, Shanghai Sixth People`s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Gastroenterology, The Tenth Affiliated Hospital, Southern Medical University (Dongguan People`s Hospital), Dongguan, China1 Department of Gerontology, Shanghai Sixth People`s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China1 Department of Gerontology, Shanghai Sixth People`s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China1 Department of Gerontology, Shanghai Sixth People`s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China2 Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People`s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China3 Shanghai BestCovered, Shanghai, China3 Shanghai BestCovered, Shanghai, ChinaAlzheimer’s disease (AD) is a common cause of dementia, characterised by cerebral amyloid-β deposition, pathological tau and neurodegeneration. The prodromal stage of AD (pAD) refers to patients with mild cognitive impairment (MCI) and evidence of AD’s pathology. At this stage, disease-modifying interventions should be used to prevent the progression to dementia. Given the inherent heterogeneity of MCI, more specific biomarkers are needed to elucidate the underlying AD’s pathology. Although the uses of cerebrospinal fluid and positron emission tomography are widely accepted methods for detecting AD’s pathology, their clinical applications are limited by their high costs and invasiveness, particularly in low-income areas in China. Therefore, to improve the early detection of Alzheimer's disease (AD) pathology through cost-effective screening methods, a panel of 45 neurologists, psychiatrists and gerontologists was invited to establish a formal consensus on the screening of pAD in China. The supportive evidence and grades of recommendations are based on a systematic literature review and focus group discussion. National meetings were held to allow participants to review, vote and provide their expert opinions to reach a consensus. A majority (two-thirds) decision was used for questions for which consensus could not be reached. Recommended screening methods are presented in this publication, including neuropsychological assessment, peripheral biomarkers and brain imaging. In addition, a general workflow for screening pAD in China is established, which will help clinicians identify individuals at high risk and determine therapeutic targets.https://gpsych.bmj.com/content/37/1/e101310.full |
| spellingShingle | Yao Lu Ying Wang Jianping Jia Qihao Guo Ya Miao Lin Huang Xiaochun Chen Qinjie Li Fengfeng Pan Liang Cui Tianlu Chen Yatian Li Jingnan Wu Consensus on rapid screening for prodromal Alzheimer’s disease in China General Psychiatry |
| title | Consensus on rapid screening for prodromal Alzheimer’s disease in China |
| title_full | Consensus on rapid screening for prodromal Alzheimer’s disease in China |
| title_fullStr | Consensus on rapid screening for prodromal Alzheimer’s disease in China |
| title_full_unstemmed | Consensus on rapid screening for prodromal Alzheimer’s disease in China |
| title_short | Consensus on rapid screening for prodromal Alzheimer’s disease in China |
| title_sort | consensus on rapid screening for prodromal alzheimer s disease in china |
| url | https://gpsych.bmj.com/content/37/1/e101310.full |
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