Comparison of Photopic Negative Response of Full-Field and Focal Electroretinograms in Detecting Glaucomatous Eyes
Purpose. To compare the photopic negative response (PhNR) of the full-field electroretinogram (ERG) to the PhNR of the focal ERGs in detecting glaucoma. Methods. One hundred and three eyes with glaucoma and 42 normal eyes were studied. Full-field ERGs were elicited by red stimuli on a blue backgroun...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2011/564131 |
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| author | Shigeki Machida Kunifusa Tamada Taku Oikawa Yasutaka Gotoh Tomoharu Nishimura Muneyoshi Kaneko Daijiro Kurosaka |
| author_facet | Shigeki Machida Kunifusa Tamada Taku Oikawa Yasutaka Gotoh Tomoharu Nishimura Muneyoshi Kaneko Daijiro Kurosaka |
| author_sort | Shigeki Machida |
| collection | DOAJ |
| description | Purpose. To compare the photopic negative response (PhNR) of the full-field electroretinogram (ERG) to the PhNR of the focal ERGs in detecting glaucoma. Methods. One hundred and three eyes with glaucoma and 42 normal eyes were studied. Full-field ERGs were elicited by red stimuli on a blue background. The focal ERGs were elicited by a 15∘ white stimulus spot centered on the macula, the superotemporal or the inferotemporal areas of the macula. Results. In early glaucoma, the areas under the receiver operating characteristic curves (AUCs) were significantly larger for the focal PhNR (0.863–0.924) than those for the full-field PhNR (0.666–0.748) (P<.05). The sensitivity was significantly higher for the focal PhNR than for the full-field PhNR in early (P<.01) and intermediate glaucoma (P<.05). In advanced glaucoma, there was no difference in the AUCs and sensitivities between the focal and full-field PhNRs. Conclusions. The focal ERG has the diagnostic ability with higher sensitivity in detecting early and intermediate glaucoma than the full-field ERG. |
| format | Article |
| id | doaj-art-16b2068d19c5438bb07c462cda8c6ba7 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-16b2068d19c5438bb07c462cda8c6ba72025-02-03T01:01:18ZengWileyJournal of Ophthalmology2090-004X2090-00582011-01-01201110.1155/2011/564131564131Comparison of Photopic Negative Response of Full-Field and Focal Electroretinograms in Detecting Glaucomatous EyesShigeki Machida0Kunifusa Tamada1Taku Oikawa2Yasutaka Gotoh3Tomoharu Nishimura4Muneyoshi Kaneko5Daijiro Kurosaka6Department of Ophthalmology, School of Medicine, Iwate Medical University, 19-1 Uchimaru Morioka, Iwate 020-8505, JapanDepartment of Ophthalmology, School of Medicine, Iwate Medical University, 19-1 Uchimaru Morioka, Iwate 020-8505, JapanDepartment of Ophthalmology, School of Medicine, Iwate Medical University, 19-1 Uchimaru Morioka, Iwate 020-8505, JapanDepartment of Ophthalmology, School of Medicine, Iwate Medical University, 19-1 Uchimaru Morioka, Iwate 020-8505, JapanDepartment of Ophthalmology, School of Medicine, Iwate Medical University, 19-1 Uchimaru Morioka, Iwate 020-8505, JapanDepartment of Ophthalmology, School of Medicine, Iwate Medical University, 19-1 Uchimaru Morioka, Iwate 020-8505, JapanDepartment of Ophthalmology, School of Medicine, Iwate Medical University, 19-1 Uchimaru Morioka, Iwate 020-8505, JapanPurpose. To compare the photopic negative response (PhNR) of the full-field electroretinogram (ERG) to the PhNR of the focal ERGs in detecting glaucoma. Methods. One hundred and three eyes with glaucoma and 42 normal eyes were studied. Full-field ERGs were elicited by red stimuli on a blue background. The focal ERGs were elicited by a 15∘ white stimulus spot centered on the macula, the superotemporal or the inferotemporal areas of the macula. Results. In early glaucoma, the areas under the receiver operating characteristic curves (AUCs) were significantly larger for the focal PhNR (0.863–0.924) than those for the full-field PhNR (0.666–0.748) (P<.05). The sensitivity was significantly higher for the focal PhNR than for the full-field PhNR in early (P<.01) and intermediate glaucoma (P<.05). In advanced glaucoma, there was no difference in the AUCs and sensitivities between the focal and full-field PhNRs. Conclusions. The focal ERG has the diagnostic ability with higher sensitivity in detecting early and intermediate glaucoma than the full-field ERG.http://dx.doi.org/10.1155/2011/564131 |
| spellingShingle | Shigeki Machida Kunifusa Tamada Taku Oikawa Yasutaka Gotoh Tomoharu Nishimura Muneyoshi Kaneko Daijiro Kurosaka Comparison of Photopic Negative Response of Full-Field and Focal Electroretinograms in Detecting Glaucomatous Eyes Journal of Ophthalmology |
| title | Comparison of Photopic Negative Response of Full-Field and Focal Electroretinograms in Detecting Glaucomatous Eyes |
| title_full | Comparison of Photopic Negative Response of Full-Field and Focal Electroretinograms in Detecting Glaucomatous Eyes |
| title_fullStr | Comparison of Photopic Negative Response of Full-Field and Focal Electroretinograms in Detecting Glaucomatous Eyes |
| title_full_unstemmed | Comparison of Photopic Negative Response of Full-Field and Focal Electroretinograms in Detecting Glaucomatous Eyes |
| title_short | Comparison of Photopic Negative Response of Full-Field and Focal Electroretinograms in Detecting Glaucomatous Eyes |
| title_sort | comparison of photopic negative response of full field and focal electroretinograms in detecting glaucomatous eyes |
| url | http://dx.doi.org/10.1155/2011/564131 |
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