Hair Cell Protection from Ototoxic Drugs
Hearing loss is often caused by death of sensory hair cells (HCs) in the inner ear. HCs are vulnerable to some ototoxic drugs, such as aminoglycosides(AGs) and the cisplatin.The most predominant form of drug-induced cell death is apoptosis. Many efforts have been made to protect HCs from cell death...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/4909237 |
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| _version_ | 1832567633726144512 |
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| author | Peng Wu Xianmin Wu Chunhong Zhang Xiaoyun Chen Yideng Huang He Li |
| author_facet | Peng Wu Xianmin Wu Chunhong Zhang Xiaoyun Chen Yideng Huang He Li |
| author_sort | Peng Wu |
| collection | DOAJ |
| description | Hearing loss is often caused by death of sensory hair cells (HCs) in the inner ear. HCs are vulnerable to some ototoxic drugs, such as aminoglycosides(AGs) and the cisplatin.The most predominant form of drug-induced cell death is apoptosis. Many efforts have been made to protect HCs from cell death after ototoxic drug exposure. These mechanisms and potential targets of HCs protection will be discussed in this review.And we also propose further investigation in the field of HCs necrosis and regeneration, as well as future clinical utilization. |
| format | Article |
| id | doaj-art-16af004f3db34f088551cd93a1a2e65a |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-16af004f3db34f088551cd93a1a2e65a2025-02-03T01:00:48ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/49092374909237Hair Cell Protection from Ototoxic DrugsPeng Wu0Xianmin Wu1Chunhong Zhang2Xiaoyun Chen3Yideng Huang4He Li5Department of Otolaryngology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou City, 325000 Zhejiang Province, ChinaDepartment of Otolaryngology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou City, 325000 Zhejiang Province, ChinaDepartment of Otolaryngology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou City, 325000 Zhejiang Province, ChinaDepartment of Otolaryngology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou City, 325000 Zhejiang Province, ChinaDepartment of Otolaryngology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou City, 325000 Zhejiang Province, ChinaDepartment of Otolaryngology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou City, 325000 Zhejiang Province, ChinaHearing loss is often caused by death of sensory hair cells (HCs) in the inner ear. HCs are vulnerable to some ototoxic drugs, such as aminoglycosides(AGs) and the cisplatin.The most predominant form of drug-induced cell death is apoptosis. Many efforts have been made to protect HCs from cell death after ototoxic drug exposure. These mechanisms and potential targets of HCs protection will be discussed in this review.And we also propose further investigation in the field of HCs necrosis and regeneration, as well as future clinical utilization.http://dx.doi.org/10.1155/2021/4909237 |
| spellingShingle | Peng Wu Xianmin Wu Chunhong Zhang Xiaoyun Chen Yideng Huang He Li Hair Cell Protection from Ototoxic Drugs Neural Plasticity |
| title | Hair Cell Protection from Ototoxic Drugs |
| title_full | Hair Cell Protection from Ototoxic Drugs |
| title_fullStr | Hair Cell Protection from Ototoxic Drugs |
| title_full_unstemmed | Hair Cell Protection from Ototoxic Drugs |
| title_short | Hair Cell Protection from Ototoxic Drugs |
| title_sort | hair cell protection from ototoxic drugs |
| url | http://dx.doi.org/10.1155/2021/4909237 |
| work_keys_str_mv | AT pengwu haircellprotectionfromototoxicdrugs AT xianminwu haircellprotectionfromototoxicdrugs AT chunhongzhang haircellprotectionfromototoxicdrugs AT xiaoyunchen haircellprotectionfromototoxicdrugs AT yidenghuang haircellprotectionfromototoxicdrugs AT heli haircellprotectionfromototoxicdrugs |