A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis

A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis

Abstract 5′AMP‐activated kinase (AMPK) constitutes a hub for cellular metabolic and growth control, thus representing an ideal therapeutic target for prostate cancers (PCas) characterized by increased lipogenesis and activation of mTORC1 pathway. However, whether AMPK activation itself is sufficient...

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Bibliographic Details
Main Authors: Giorgia Zadra, Cornelia Photopoulos, Svitlana Tyekucheva, Pedram Heidari, Qing Ping Weng, Giuseppe Fedele, Hong Liu, Natalia Scaglia, Carmen Priolo, Ewa Sicinska, Umar Mahmood, Sabina Signoretti, Neal Birnberg, Massimo Loda
Format: Article
Language:English
Published: Springer Nature 2014-02-01
Series:EMBO Molecular Medicine
Subjects:
AMPK direct activation
androgen signaling inhibitors
de novo lipogenesis
MT 63–78
prostate cancer
Online Access:https://doi.org/10.1002/emmm.201302734
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https://doi.org/10.1002/emmm.201302734

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