Synthesis and Microbial Activity of Novel 3-Methyl-2-pyrazolin-5-one Derivatives
2-Oxo-2H-chromene-3-carbohydrazide derivatives 2a,b react with 2-{[4-(substituted thiazol-2-yl)iminoethyl)-phenyl]hydrazono}-3-oxo-butyric acid ethyl esters 4a–c to give 3-methyl-1-[(2-oxo-2H-chromen-3-yl) carbonyl]-4-{[4-(substituted thiazol-2-yl)iminoethyl)-phenyl]hydrazono}]-2-pyrazolin-5-one der...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/183130 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562719215058944 |
|---|---|
| author | Mohamed S. Mostafa Nasser M. Abd El-Salam Othman Y. Alothman |
| author_facet | Mohamed S. Mostafa Nasser M. Abd El-Salam Othman Y. Alothman |
| author_sort | Mohamed S. Mostafa |
| collection | DOAJ |
| description | 2-Oxo-2H-chromene-3-carbohydrazide derivatives 2a,b react with 2-{[4-(substituted thiazol-2-yl)iminoethyl)-phenyl]hydrazono}-3-oxo-butyric acid ethyl esters 4a–c to give 3-methyl-1-[(2-oxo-2H-chromen-3-yl) carbonyl]-4-{[4-(substituted thiazol-2-yl)iminoethyl)-phenyl]hydrazono}]-2-pyrazolin-5-one derivatives 5a–f. A considerable increase in the reaction rate had been observed with better yield using microwave irradiation for the synthesis of compounds 2a, b, 3a–c, and 5a–f. The synthesized products were tested against B. subtilis, S. aureus, and E. coli as well as C. albicans compared with tetracycline and nystatin as reference drugs. |
| format | Article |
| id | doaj-art-1692c9daca644292b0a37ed83733e521 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-1692c9daca644292b0a37ed83733e5212025-02-03T01:21:54ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/183130183130Synthesis and Microbial Activity of Novel 3-Methyl-2-pyrazolin-5-one DerivativesMohamed S. Mostafa0Nasser M. Abd El-Salam1Othman Y. Alothman2Chemistry Department, Faculty of Science, Jazan University, P.O. Box 2079, Saudi ArabiaRiyadh Community College, King Saud University, P.O. Box 28095, Riyadh 11437, Saudi ArabiaDepartment of Chemical Engineering, College of Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi Arabia2-Oxo-2H-chromene-3-carbohydrazide derivatives 2a,b react with 2-{[4-(substituted thiazol-2-yl)iminoethyl)-phenyl]hydrazono}-3-oxo-butyric acid ethyl esters 4a–c to give 3-methyl-1-[(2-oxo-2H-chromen-3-yl) carbonyl]-4-{[4-(substituted thiazol-2-yl)iminoethyl)-phenyl]hydrazono}]-2-pyrazolin-5-one derivatives 5a–f. A considerable increase in the reaction rate had been observed with better yield using microwave irradiation for the synthesis of compounds 2a, b, 3a–c, and 5a–f. The synthesized products were tested against B. subtilis, S. aureus, and E. coli as well as C. albicans compared with tetracycline and nystatin as reference drugs.http://dx.doi.org/10.1155/2013/183130 |
| spellingShingle | Mohamed S. Mostafa Nasser M. Abd El-Salam Othman Y. Alothman Synthesis and Microbial Activity of Novel 3-Methyl-2-pyrazolin-5-one Derivatives Journal of Chemistry |
| title | Synthesis and Microbial Activity of Novel 3-Methyl-2-pyrazolin-5-one Derivatives |
| title_full | Synthesis and Microbial Activity of Novel 3-Methyl-2-pyrazolin-5-one Derivatives |
| title_fullStr | Synthesis and Microbial Activity of Novel 3-Methyl-2-pyrazolin-5-one Derivatives |
| title_full_unstemmed | Synthesis and Microbial Activity of Novel 3-Methyl-2-pyrazolin-5-one Derivatives |
| title_short | Synthesis and Microbial Activity of Novel 3-Methyl-2-pyrazolin-5-one Derivatives |
| title_sort | synthesis and microbial activity of novel 3 methyl 2 pyrazolin 5 one derivatives |
| url | http://dx.doi.org/10.1155/2013/183130 |
| work_keys_str_mv | AT mohamedsmostafa synthesisandmicrobialactivityofnovel3methyl2pyrazolin5onederivatives AT nassermabdelsalam synthesisandmicrobialactivityofnovel3methyl2pyrazolin5onederivatives AT othmanyalothman synthesisandmicrobialactivityofnovel3methyl2pyrazolin5onederivatives |