Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology
The discovery of a series of genetic and serological markers associated with disease susceptibility and phenotype in inflammatory bowel disease has led to the prospect of an integrated classification system involving clinical, serological and genetic parameters. The Working Party has reviewed curren...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2005-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2005/269076 |
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| Summary: | The discovery of a series of genetic and serological markers associated
with disease susceptibility and phenotype in inflammatory bowel disease
has led to the prospect of an integrated classification system
involving clinical, serological and genetic parameters. The Working
Party has reviewed current clinical classification systems in Crohn’s
disease, ulcerative colitis and indeterminate colitis, and provided recommendations
for clinical classification in practice. Progress with
respect to integrating serological and genetic markers has been examined
in detail, and the implications are discussed. While an integrated
system is not proposed for clinical use at present, the introduction of a
widely acceptable clinical subclassification is strongly advocated,
which would allow detailed correlations among serotype, genotype and
clinical phenotype to be examined and confirmed in independent
cohorts of patients and, thereby, provide a vital foundation for future
work. |
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| ISSN: | 0835-7900 |