Imidazole and Azo-Based Schiff Bases Ligands as Highly Active Antifungal and Antioxidant Components
We describe, herein, the synthesis, full characterization, and optical properties of four different ligands L1-L4 which associate an azo group, an imidazole unit, and a Schiff base fragment. The UV-visible absorption bands are characteristic of π→π⁎ and n→π⁎ transitions with an additional charge tra...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Heteroatom Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2019/6862170 |
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| author | Siham Slassi Adeline Fix-Tailler Gérald Larcher Amina Amine Abdelkrim El-Ghayoury |
| author_facet | Siham Slassi Adeline Fix-Tailler Gérald Larcher Amina Amine Abdelkrim El-Ghayoury |
| author_sort | Siham Slassi |
| collection | DOAJ |
| description | We describe, herein, the synthesis, full characterization, and optical properties of four different ligands L1-L4 which associate an azo group, an imidazole unit, and a Schiff base fragment. The UV-visible absorption bands are characteristic of π→π⁎ and n→π⁎ transitions with an additional charge transfer between the azobenzene moiety and the imino group. Finally the determination of MIC80 values against pathogenic fungi such as S. apiospermum, A. fumigatus, and C. albicans revealed that these ligands have effective antifungal properties with highest activities (MIC80) on C. albicans for the azole based ligands L1-L3. DPPH radical scavenging of the studied ligands was also tested. |
| format | Article |
| id | doaj-art-1689cd2874874c9684d264040b5ff3a9 |
| institution | Kabale University |
| issn | 1042-7163 1098-1071 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Heteroatom Chemistry |
| spelling | doaj-art-1689cd2874874c9684d264040b5ff3a92025-02-03T01:30:55ZengWileyHeteroatom Chemistry1042-71631098-10712019-01-01201910.1155/2019/68621706862170Imidazole and Azo-Based Schiff Bases Ligands as Highly Active Antifungal and Antioxidant ComponentsSiham Slassi0Adeline Fix-Tailler1Gérald Larcher2Amina Amine3Abdelkrim El-Ghayoury4Université d’Angers, CNRS UMR 6200, Laboratoire MOLTECH-Anjou, 2 bd Lavoisier, 49045 Angers Cedex, FranceUniversité d’Angers, Groupe d'Etude des Interactions Hôte-Pathogène (GEIHP, EA 3142), Institut de Biologie en Santé-IRIS, CHU, 4 rue Larrey, 49933 Angers Cedex, FranceUniversité d’Angers, Groupe d'Etude des Interactions Hôte-Pathogène (GEIHP, EA 3142), Institut de Biologie en Santé-IRIS, CHU, 4 rue Larrey, 49933 Angers Cedex, FranceLCBAE, Equipe Chimie Moléculaire et Molécules Bioactives, Université Moulay Ismail, Faculté des Sciences Meknès, MoroccoUniversité d’Angers, CNRS UMR 6200, Laboratoire MOLTECH-Anjou, 2 bd Lavoisier, 49045 Angers Cedex, FranceWe describe, herein, the synthesis, full characterization, and optical properties of four different ligands L1-L4 which associate an azo group, an imidazole unit, and a Schiff base fragment. The UV-visible absorption bands are characteristic of π→π⁎ and n→π⁎ transitions with an additional charge transfer between the azobenzene moiety and the imino group. Finally the determination of MIC80 values against pathogenic fungi such as S. apiospermum, A. fumigatus, and C. albicans revealed that these ligands have effective antifungal properties with highest activities (MIC80) on C. albicans for the azole based ligands L1-L3. DPPH radical scavenging of the studied ligands was also tested.http://dx.doi.org/10.1155/2019/6862170 |
| spellingShingle | Siham Slassi Adeline Fix-Tailler Gérald Larcher Amina Amine Abdelkrim El-Ghayoury Imidazole and Azo-Based Schiff Bases Ligands as Highly Active Antifungal and Antioxidant Components Heteroatom Chemistry |
| title | Imidazole and Azo-Based Schiff Bases Ligands as Highly Active Antifungal and Antioxidant Components |
| title_full | Imidazole and Azo-Based Schiff Bases Ligands as Highly Active Antifungal and Antioxidant Components |
| title_fullStr | Imidazole and Azo-Based Schiff Bases Ligands as Highly Active Antifungal and Antioxidant Components |
| title_full_unstemmed | Imidazole and Azo-Based Schiff Bases Ligands as Highly Active Antifungal and Antioxidant Components |
| title_short | Imidazole and Azo-Based Schiff Bases Ligands as Highly Active Antifungal and Antioxidant Components |
| title_sort | imidazole and azo based schiff bases ligands as highly active antifungal and antioxidant components |
| url | http://dx.doi.org/10.1155/2019/6862170 |
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