Comparison of Optical Coherence Tomography Angiography and Laser Speckle Flowgraphy for the Diagnosis of Normal-Tension Glaucoma
Purpose. To compare optical coherence tomography angiography (OCT-A) and laser speckle flowgraphy (LSFG) for the diagnosis of normal-tension glaucoma (NTG). Methods. Twenty-eight eyes of 28 patients with NTG and 25 eyes of 25 normal subjects matched for age, refractive errors, systemic blood pressur...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2018/1751857 |
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| author | Asuka Takeyama Kyoko Ishida Ayako Anraku Masahiro Ishida Goji Tomita |
| author_facet | Asuka Takeyama Kyoko Ishida Ayako Anraku Masahiro Ishida Goji Tomita |
| author_sort | Asuka Takeyama |
| collection | DOAJ |
| description | Purpose. To compare optical coherence tomography angiography (OCT-A) and laser speckle flowgraphy (LSFG) for the diagnosis of normal-tension glaucoma (NTG). Methods. Twenty-eight eyes of 28 patients with NTG and 25 eyes of 25 normal subjects matched for age, refractive errors, systemic blood pressure, and central corneal thickness were evaluated. OCT-A was used to measure whole image vessel density, inside disc vessel density, and peripapillary vessel density; using LSFG, mean blur rate (MBR) inside the whole optic nerve head (ONH) area (MBRA), and MBR of the vessel area (MBRV) and tissue area (MBRT) inside the ONH, were determined. Receiver operating characteristic (ROC) curves and areas under the ROC (AUROC) were used to assess the diagnostic ability of each variable. Results. The AUROC for OCT-A whole image vessel density (0.950) was significantly greater than that for OCT-A peripapillary vessel density (0.830) and for all LSFG parameters (MBRA = 0.793, MBRV = 0.601, and MBRT = 0.61) (P<0.001). The AUROC for OCT-A inside disc vessel density (0.931) was significantly greater than that for all LSFG parameters (P<0.005). Conclusions. OCT-A vessel density had a higher glaucoma diagnostic ability compared to all LSFG parameters in patients with NTG. |
| format | Article |
| id | doaj-art-167807221c2f42a4847f0bdfcec70ae4 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-167807221c2f42a4847f0bdfcec70ae42025-02-03T01:10:24ZengWileyJournal of Ophthalmology2090-004X2090-00582018-01-01201810.1155/2018/17518571751857Comparison of Optical Coherence Tomography Angiography and Laser Speckle Flowgraphy for the Diagnosis of Normal-Tension GlaucomaAsuka Takeyama0Kyoko Ishida1Ayako Anraku2Masahiro Ishida3Goji Tomita4Department of Ophthalmology, Teikyo University Hospital, Mizonokuchi, Kawasaki, JapanDepartment of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, JapanDepartment of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, JapanDepartment of Ophthalmology, Teikyo University Hospital, Mizonokuchi, Kawasaki, JapanDepartment of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, JapanPurpose. To compare optical coherence tomography angiography (OCT-A) and laser speckle flowgraphy (LSFG) for the diagnosis of normal-tension glaucoma (NTG). Methods. Twenty-eight eyes of 28 patients with NTG and 25 eyes of 25 normal subjects matched for age, refractive errors, systemic blood pressure, and central corneal thickness were evaluated. OCT-A was used to measure whole image vessel density, inside disc vessel density, and peripapillary vessel density; using LSFG, mean blur rate (MBR) inside the whole optic nerve head (ONH) area (MBRA), and MBR of the vessel area (MBRV) and tissue area (MBRT) inside the ONH, were determined. Receiver operating characteristic (ROC) curves and areas under the ROC (AUROC) were used to assess the diagnostic ability of each variable. Results. The AUROC for OCT-A whole image vessel density (0.950) was significantly greater than that for OCT-A peripapillary vessel density (0.830) and for all LSFG parameters (MBRA = 0.793, MBRV = 0.601, and MBRT = 0.61) (P<0.001). The AUROC for OCT-A inside disc vessel density (0.931) was significantly greater than that for all LSFG parameters (P<0.005). Conclusions. OCT-A vessel density had a higher glaucoma diagnostic ability compared to all LSFG parameters in patients with NTG.http://dx.doi.org/10.1155/2018/1751857 |
| spellingShingle | Asuka Takeyama Kyoko Ishida Ayako Anraku Masahiro Ishida Goji Tomita Comparison of Optical Coherence Tomography Angiography and Laser Speckle Flowgraphy for the Diagnosis of Normal-Tension Glaucoma Journal of Ophthalmology |
| title | Comparison of Optical Coherence Tomography Angiography and Laser Speckle Flowgraphy for the Diagnosis of Normal-Tension Glaucoma |
| title_full | Comparison of Optical Coherence Tomography Angiography and Laser Speckle Flowgraphy for the Diagnosis of Normal-Tension Glaucoma |
| title_fullStr | Comparison of Optical Coherence Tomography Angiography and Laser Speckle Flowgraphy for the Diagnosis of Normal-Tension Glaucoma |
| title_full_unstemmed | Comparison of Optical Coherence Tomography Angiography and Laser Speckle Flowgraphy for the Diagnosis of Normal-Tension Glaucoma |
| title_short | Comparison of Optical Coherence Tomography Angiography and Laser Speckle Flowgraphy for the Diagnosis of Normal-Tension Glaucoma |
| title_sort | comparison of optical coherence tomography angiography and laser speckle flowgraphy for the diagnosis of normal tension glaucoma |
| url | http://dx.doi.org/10.1155/2018/1751857 |
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