K(Ca)3.1 channel-blockade attenuates airway pathophysiology in a sheep model of chronic asthma.

K(Ca)3.1 channel-blockade attenuates airway pathophysiology in a sheep model of chronic asthma.

<h4>Background</h4>The Ca(2+)-activated K(+) channel K(Ca)3.1 is expressed in several structural and inflammatory airway cell types and is proposed to play an important role in the pathophysiology of asthma. The aim of the current study was to determine whether inhibition of K(Ca)3.1 mod...

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Bibliographic Details
Main Authors: Joanne Van Der Velden, Grace Sum, Donna Barker, Emmanuel Koumoundouros, Garry Barcham, Heike Wulff, Neil Castle, Peter Bradding, Kenneth Snibson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0066886&type=printable
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