Lactobacillus reuteri ZJ617 attenuates metabolic syndrome via microbiota-derived spermidine
Abstract Metabolic syndrome (MetS) is a difficult-to-manage disease that poses a significant risk to human health. Here, we show that the supplementation of Lactobacillus reuteri ZJ617 ameliorates symptoms of MetS in mice induced by the high-fat diet. L. reuteri ZJ617 modulates host metabolism by in...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-56105-4 |
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| author | Yanfei Ma Yifan Zhong Wenjie Tang Teresa G. Valencak Jingliang Liu Zhaoxi Deng Jiangdi Mao Daren Liu Shanshan Wang Yuhao Wang Haifeng Wang |
| author_facet | Yanfei Ma Yifan Zhong Wenjie Tang Teresa G. Valencak Jingliang Liu Zhaoxi Deng Jiangdi Mao Daren Liu Shanshan Wang Yuhao Wang Haifeng Wang |
| author_sort | Yanfei Ma |
| collection | DOAJ |
| description | Abstract Metabolic syndrome (MetS) is a difficult-to-manage disease that poses a significant risk to human health. Here, we show that the supplementation of Lactobacillus reuteri ZJ617 ameliorates symptoms of MetS in mice induced by the high-fat diet. L. reuteri ZJ617 modulates host metabolism by interacting with the microbiome, resulting in the production of spermidine synthesized by the microbiota. L. reuteri ZJ617 serves as a source of substrates for the microbiota to synthesize spermidine, hence preventing the decline of bacteria responsible for spermidine production. Spermidine treatment mimics the metabolic effects of L. reuteri ZJ617, whereas pharmacological inhibition of spermidine biosynthesis in mice abolishes these benefits. Our findings reveal the mechanism by which L. reuteri ZJ617 alleviates MetS symptoms and provide support for its potential use as a probiotic for promoting metabolic health. |
| format | Article |
| id | doaj-art-16667cb93f8c4466ae6075cd587a9911 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-16667cb93f8c4466ae6075cd587a99112025-01-26T12:41:07ZengNature PortfolioNature Communications2041-17232025-01-0116111510.1038/s41467-025-56105-4Lactobacillus reuteri ZJ617 attenuates metabolic syndrome via microbiota-derived spermidineYanfei Ma0Yifan Zhong1Wenjie Tang2Teresa G. Valencak3Jingliang Liu4Zhaoxi Deng5Jiangdi Mao6Daren Liu7Shanshan Wang8Yuhao Wang9Haifeng Wang10The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang UniversityThe Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang UniversityThe Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang UniversityThe Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang UniversityThe Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang UniversityThe Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang UniversityThe Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang UniversityThe Second Affiliated Hospital of Zhejiang UniversityThe Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang UniversityInstitute of Translational Medicine, Zhejiang University School of MedicineThe Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang UniversityAbstract Metabolic syndrome (MetS) is a difficult-to-manage disease that poses a significant risk to human health. Here, we show that the supplementation of Lactobacillus reuteri ZJ617 ameliorates symptoms of MetS in mice induced by the high-fat diet. L. reuteri ZJ617 modulates host metabolism by interacting with the microbiome, resulting in the production of spermidine synthesized by the microbiota. L. reuteri ZJ617 serves as a source of substrates for the microbiota to synthesize spermidine, hence preventing the decline of bacteria responsible for spermidine production. Spermidine treatment mimics the metabolic effects of L. reuteri ZJ617, whereas pharmacological inhibition of spermidine biosynthesis in mice abolishes these benefits. Our findings reveal the mechanism by which L. reuteri ZJ617 alleviates MetS symptoms and provide support for its potential use as a probiotic for promoting metabolic health.https://doi.org/10.1038/s41467-025-56105-4 |
| spellingShingle | Yanfei Ma Yifan Zhong Wenjie Tang Teresa G. Valencak Jingliang Liu Zhaoxi Deng Jiangdi Mao Daren Liu Shanshan Wang Yuhao Wang Haifeng Wang Lactobacillus reuteri ZJ617 attenuates metabolic syndrome via microbiota-derived spermidine Nature Communications |
| title | Lactobacillus reuteri ZJ617 attenuates metabolic syndrome via microbiota-derived spermidine |
| title_full | Lactobacillus reuteri ZJ617 attenuates metabolic syndrome via microbiota-derived spermidine |
| title_fullStr | Lactobacillus reuteri ZJ617 attenuates metabolic syndrome via microbiota-derived spermidine |
| title_full_unstemmed | Lactobacillus reuteri ZJ617 attenuates metabolic syndrome via microbiota-derived spermidine |
| title_short | Lactobacillus reuteri ZJ617 attenuates metabolic syndrome via microbiota-derived spermidine |
| title_sort | lactobacillus reuteri zj617 attenuates metabolic syndrome via microbiota derived spermidine |
| url | https://doi.org/10.1038/s41467-025-56105-4 |
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