Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes
Type 2 diabetes mellitus (T2DM), characterized by insulin resistance and unclear pathogenesis, is a serious menace to human health. Bile acids are the end products of cholesterol catabolism and play an important role in maintaining cholesterol homeostasis. Furthermore, increasing studies suggest tha...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/6138438 |
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| _version_ | 1832546992573644800 |
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| author | Yingjie Wu An Zhou Li Tang Yuanyuan Lei Bo Tang Linjing Zhang |
| author_facet | Yingjie Wu An Zhou Li Tang Yuanyuan Lei Bo Tang Linjing Zhang |
| author_sort | Yingjie Wu |
| collection | DOAJ |
| description | Type 2 diabetes mellitus (T2DM), characterized by insulin resistance and unclear pathogenesis, is a serious menace to human health. Bile acids are the end products of cholesterol catabolism and play an important role in maintaining cholesterol homeostasis. Furthermore, increasing studies suggest that bile acids may regulate glucose tolerance, insulin sensitivity, and energy metabolism, suggesting that bile acids may represent a potential therapeutic target for T2DM. This study summarizes the metabolism of bile acids and, more importantly, changes in their concentrations, constitution, and receptors in diabetes. Furthermore, we provide an overview of the mechanisms underlying the role of bile acids in glucose and lipid metabolism, as well as the occurrence and development of T2DM. Bile acid-targeted therapy may represent a valid approach for T2DM treatment. |
| format | Article |
| id | doaj-art-1658e1434c3a415da4c4c31ecb5713f9 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-1658e1434c3a415da4c4c31ecb5713f92025-02-03T06:46:18ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/61384386138438Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 DiabetesYingjie Wu0An Zhou1Li Tang2Yuanyuan Lei3Bo Tang4Linjing Zhang5Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaDepartment of Nuclear Medicine, Southwest Hospital, Third Military Medical University, Chongqing 400038, ChinaType 2 diabetes mellitus (T2DM), characterized by insulin resistance and unclear pathogenesis, is a serious menace to human health. Bile acids are the end products of cholesterol catabolism and play an important role in maintaining cholesterol homeostasis. Furthermore, increasing studies suggest that bile acids may regulate glucose tolerance, insulin sensitivity, and energy metabolism, suggesting that bile acids may represent a potential therapeutic target for T2DM. This study summarizes the metabolism of bile acids and, more importantly, changes in their concentrations, constitution, and receptors in diabetes. Furthermore, we provide an overview of the mechanisms underlying the role of bile acids in glucose and lipid metabolism, as well as the occurrence and development of T2DM. Bile acid-targeted therapy may represent a valid approach for T2DM treatment.http://dx.doi.org/10.1155/2020/6138438 |
| spellingShingle | Yingjie Wu An Zhou Li Tang Yuanyuan Lei Bo Tang Linjing Zhang Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes Journal of Diabetes Research |
| title | Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes |
| title_full | Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes |
| title_fullStr | Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes |
| title_full_unstemmed | Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes |
| title_short | Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes |
| title_sort | bile acids key regulators and novel treatment targets for type 2 diabetes |
| url | http://dx.doi.org/10.1155/2020/6138438 |
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