Feeding disruptions lead to a significant increase in disease modules in adult mice
Feeding disruption is closely linked to numerous diseases, yet the underlying molecular mechanisms remain an important but unresolved issue at the molecular level. We hypothesize that, at the network level, dietary disruptions can alter gene co-expression patterns, leading to an increase in disease-...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025001549 |
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| author | Xiaoqin Mou Pengxing Nie Renrui Chen Yang Cheng Guang-Zhong Wang |
| author_facet | Xiaoqin Mou Pengxing Nie Renrui Chen Yang Cheng Guang-Zhong Wang |
| author_sort | Xiaoqin Mou |
| collection | DOAJ |
| description | Feeding disruption is closely linked to numerous diseases, yet the underlying molecular mechanisms remain an important but unresolved issue at the molecular level. We hypothesize that, at the network level, dietary disruptions can alter gene co-expression patterns, leading to an increase in disease-associated modules, and thereby elevating the likelihood of disease occurrence. Here, we investigate this hypothesis using transcriptomic data from a large cohort of adult mice subjected to feeding disruptions. Our computational analysis indicates that altered feeding schedules significantly increase disease-related modules in adult mouse livers, well before aging and disease onset. Conversely, calorie restriction significantly reduces these disease modules. This provides a critical missing link between feeding disruption and the molecular mechanisms of disease. |
| format | Article |
| id | doaj-art-1653be9993d441d1bef8d6aa6b2ddfa3 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-1653be9993d441d1bef8d6aa6b2ddfa32025-02-02T05:28:09ZengElsevierHeliyon2405-84402025-01-01112e41774Feeding disruptions lead to a significant increase in disease modules in adult miceXiaoqin Mou0Pengxing Nie1Renrui Chen2Yang Cheng3Guang-Zhong Wang4CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, ChinaCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, ChinaCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, ChinaCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, ChinaCorresponding author.; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, ChinaFeeding disruption is closely linked to numerous diseases, yet the underlying molecular mechanisms remain an important but unresolved issue at the molecular level. We hypothesize that, at the network level, dietary disruptions can alter gene co-expression patterns, leading to an increase in disease-associated modules, and thereby elevating the likelihood of disease occurrence. Here, we investigate this hypothesis using transcriptomic data from a large cohort of adult mice subjected to feeding disruptions. Our computational analysis indicates that altered feeding schedules significantly increase disease-related modules in adult mouse livers, well before aging and disease onset. Conversely, calorie restriction significantly reduces these disease modules. This provides a critical missing link between feeding disruption and the molecular mechanisms of disease.http://www.sciencedirect.com/science/article/pii/S2405844025001549Feeding disruptionCalorie restrictionDisease moduleCircadian transcriptomeAging |
| spellingShingle | Xiaoqin Mou Pengxing Nie Renrui Chen Yang Cheng Guang-Zhong Wang Feeding disruptions lead to a significant increase in disease modules in adult mice Heliyon Feeding disruption Calorie restriction Disease module Circadian transcriptome Aging |
| title | Feeding disruptions lead to a significant increase in disease modules in adult mice |
| title_full | Feeding disruptions lead to a significant increase in disease modules in adult mice |
| title_fullStr | Feeding disruptions lead to a significant increase in disease modules in adult mice |
| title_full_unstemmed | Feeding disruptions lead to a significant increase in disease modules in adult mice |
| title_short | Feeding disruptions lead to a significant increase in disease modules in adult mice |
| title_sort | feeding disruptions lead to a significant increase in disease modules in adult mice |
| topic | Feeding disruption Calorie restriction Disease module Circadian transcriptome Aging |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025001549 |
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