Fine-Needle Aspiration Cytology of Parathyroid Carcinoma Mimic Hürthle Cell Thyroid Neoplasm
Background. Fine-needle aspiration (FNA) can cause misdiagnosis of cytomorphological findings between parathyroid and thyroid lesions. Case Presentation. A 31-year-old man presented with a palpable neck mass on the right thyroid lobe. FNA cytology was reported as intrathyroidal lymphoid hyperplasia....
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/680876 |
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| author | Chutintorn Sriphrapradang Pattana Sornmayura Niramol Chanplakorn Objoon Trachoo Pattarana Sae-Chew Rangsima Aroonroch |
| author_facet | Chutintorn Sriphrapradang Pattana Sornmayura Niramol Chanplakorn Objoon Trachoo Pattarana Sae-Chew Rangsima Aroonroch |
| author_sort | Chutintorn Sriphrapradang |
| collection | DOAJ |
| description | Background. Fine-needle aspiration (FNA) can cause misdiagnosis of cytomorphological findings between parathyroid and thyroid lesions. Case Presentation. A 31-year-old man presented with a palpable neck mass on the right thyroid lobe. FNA cytology was reported as intrathyroidal lymphoid hyperplasia. After 5 years, repeated FNA was done on the enlarged nodule with result of Hürthle cell lesion. Prior to right lobectomy, laboratories revealed elevated serum calcium and parathyroid hormone (PTH). Careful history taking revealed chronic knee pain and ossifying fibroma at the maxilla. Ultrasonography showed a 2.8 cm mass inferior to right thyroid lobe. Pathology from en bloc resection was parathyroid carcinoma and immunohistochemical study revealed positivity for PTH. Genetic analysis found somatic mutation of CDC73 gene in exon1 (c.70delG) which caused premature stop codon in amino acid 26 (p.Glu24Lysfs2*). The final diagnosis was hyperparathyroidism-jaw tumor syndrome. Conclusions. FNA cytology of parathyroid can mimic thyroid lesion. It is important to consider and correlate the entire information from clinical history, laboratory, imaging, and FNA. |
| format | Article |
| id | doaj-art-164fc5b3c2a04b3192a76d15342aaa53 |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-164fc5b3c2a04b3192a76d15342aaa532025-02-03T06:44:17ZengWileyCase Reports in Endocrinology2090-65012090-651X2014-01-01201410.1155/2014/680876680876Fine-Needle Aspiration Cytology of Parathyroid Carcinoma Mimic Hürthle Cell Thyroid NeoplasmChutintorn Sriphrapradang0Pattana Sornmayura1Niramol Chanplakorn2Objoon Trachoo3Pattarana Sae-Chew4Rangsima Aroonroch5Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama 6 Road, Rajthevi, Bangkok 10400, ThailandDepartment of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama 6 Road, Rajthevi, Bangkok 10400, ThailandDepartment of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama 6 Road, Rajthevi, Bangkok 10400, ThailandDepartment of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama 6 Road, Rajthevi, Bangkok 10400, ThailandResearch Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama 6 Road, Rajthevi, Bangkok 10400, ThailandDepartment of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama 6 Road, Rajthevi, Bangkok 10400, ThailandBackground. Fine-needle aspiration (FNA) can cause misdiagnosis of cytomorphological findings between parathyroid and thyroid lesions. Case Presentation. A 31-year-old man presented with a palpable neck mass on the right thyroid lobe. FNA cytology was reported as intrathyroidal lymphoid hyperplasia. After 5 years, repeated FNA was done on the enlarged nodule with result of Hürthle cell lesion. Prior to right lobectomy, laboratories revealed elevated serum calcium and parathyroid hormone (PTH). Careful history taking revealed chronic knee pain and ossifying fibroma at the maxilla. Ultrasonography showed a 2.8 cm mass inferior to right thyroid lobe. Pathology from en bloc resection was parathyroid carcinoma and immunohistochemical study revealed positivity for PTH. Genetic analysis found somatic mutation of CDC73 gene in exon1 (c.70delG) which caused premature stop codon in amino acid 26 (p.Glu24Lysfs2*). The final diagnosis was hyperparathyroidism-jaw tumor syndrome. Conclusions. FNA cytology of parathyroid can mimic thyroid lesion. It is important to consider and correlate the entire information from clinical history, laboratory, imaging, and FNA.http://dx.doi.org/10.1155/2014/680876 |
| spellingShingle | Chutintorn Sriphrapradang Pattana Sornmayura Niramol Chanplakorn Objoon Trachoo Pattarana Sae-Chew Rangsima Aroonroch Fine-Needle Aspiration Cytology of Parathyroid Carcinoma Mimic Hürthle Cell Thyroid Neoplasm Case Reports in Endocrinology |
| title | Fine-Needle Aspiration Cytology of Parathyroid Carcinoma Mimic Hürthle Cell Thyroid Neoplasm |
| title_full | Fine-Needle Aspiration Cytology of Parathyroid Carcinoma Mimic Hürthle Cell Thyroid Neoplasm |
| title_fullStr | Fine-Needle Aspiration Cytology of Parathyroid Carcinoma Mimic Hürthle Cell Thyroid Neoplasm |
| title_full_unstemmed | Fine-Needle Aspiration Cytology of Parathyroid Carcinoma Mimic Hürthle Cell Thyroid Neoplasm |
| title_short | Fine-Needle Aspiration Cytology of Parathyroid Carcinoma Mimic Hürthle Cell Thyroid Neoplasm |
| title_sort | fine needle aspiration cytology of parathyroid carcinoma mimic hurthle cell thyroid neoplasm |
| url | http://dx.doi.org/10.1155/2014/680876 |
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