Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract
There is evidence that the principles present in the widely consumed Indian food plant C. fimbriata extract (CFE) suppress appetite, and provide antiobesogenic and metabolic benefits. The Diet-Induced Obesity (DIO) rat model was used to investigate CFE's anorexigenic effects. Rats were randomly...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2010/285301 |
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| author | Soundararajan Kamalakkannan Ramaswamy Rajendran Ramasamy V. Venkatesh Paul Clayton Mohammad A. Akbarsha |
| author_facet | Soundararajan Kamalakkannan Ramaswamy Rajendran Ramasamy V. Venkatesh Paul Clayton Mohammad A. Akbarsha |
| author_sort | Soundararajan Kamalakkannan |
| collection | DOAJ |
| description | There is evidence that the principles present in the widely consumed Indian food plant C. fimbriata extract (CFE) suppress appetite, and provide antiobesogenic and metabolic benefits. The Diet-Induced Obesity (DIO) rat model was used to investigate CFE's anorexigenic effects. Rats were randomly divided into three groups: (i) untreated control (C), (ii) control for cafeteria diet (CA), and (iii) cafeteria diet fed + CFE treated. Rats in the test group received cafeteria diet and CFE from day one onwards. CFE was administered by gavage at three doses (25, 50, 100 mg/Kg BW per day) for 90 days. The antiobesogenic effects of CFE were evaluated by monitoring changes in feed intake, body weight, serum lipid and hormonal (leptin) profiles, fat pads, and liver weight. Antiatherosclerotic effects were measured by histology. CFE induced significant and dose-dependent inhibition of food intake, with dose-related prevention of gains in body weight, liver weight, and fat pad mass. Alterations in serum lipid profiles associated with weight gain were similarly inhibited, as were the typical increases in serum leptin levels. These data substantiate CFE's reported anorexigenic effects. CFE treatment also conferred protection against atherogenesis. We conclude that CFE possesses antiobesogenic and antiatherosclerotic properties. |
| format | Article |
| id | doaj-art-163ff248ccfe4ba18e9686675a9b43e0 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
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| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-163ff248ccfe4ba18e9686675a9b43e02025-02-03T05:50:13ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322010-01-01201010.1155/2010/285301285301Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata ExtractSoundararajan Kamalakkannan0Ramaswamy Rajendran1Ramasamy V. Venkatesh2Paul Clayton3Mohammad A. Akbarsha4Department of Animal Science, Bharathidasan University, Tiruchirappalli 620 024, IndiaResearch and Development, GreenChem, Bangalore 562 107, IndiaQuality Control, Gencor Pacific, Hong KongOxford Brookes University, Oxford OX3 0BP, UKMahatma Gandhi-Doerenkamp Center for Alternatives, Bharathidasan University, Tiruchirappalli-620 024, IndiaThere is evidence that the principles present in the widely consumed Indian food plant C. fimbriata extract (CFE) suppress appetite, and provide antiobesogenic and metabolic benefits. The Diet-Induced Obesity (DIO) rat model was used to investigate CFE's anorexigenic effects. Rats were randomly divided into three groups: (i) untreated control (C), (ii) control for cafeteria diet (CA), and (iii) cafeteria diet fed + CFE treated. Rats in the test group received cafeteria diet and CFE from day one onwards. CFE was administered by gavage at three doses (25, 50, 100 mg/Kg BW per day) for 90 days. The antiobesogenic effects of CFE were evaluated by monitoring changes in feed intake, body weight, serum lipid and hormonal (leptin) profiles, fat pads, and liver weight. Antiatherosclerotic effects were measured by histology. CFE induced significant and dose-dependent inhibition of food intake, with dose-related prevention of gains in body weight, liver weight, and fat pad mass. Alterations in serum lipid profiles associated with weight gain were similarly inhibited, as were the typical increases in serum leptin levels. These data substantiate CFE's reported anorexigenic effects. CFE treatment also conferred protection against atherogenesis. We conclude that CFE possesses antiobesogenic and antiatherosclerotic properties.http://dx.doi.org/10.1155/2010/285301 |
| spellingShingle | Soundararajan Kamalakkannan Ramaswamy Rajendran Ramasamy V. Venkatesh Paul Clayton Mohammad A. Akbarsha Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract Journal of Nutrition and Metabolism |
| title | Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract |
| title_full | Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract |
| title_fullStr | Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract |
| title_full_unstemmed | Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract |
| title_short | Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract |
| title_sort | antiobesogenic and antiatherosclerotic properties of caralluma fimbriata extract |
| url | http://dx.doi.org/10.1155/2010/285301 |
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