Dose-dependent enhancement of in vitro osteogenic activity on strontium-decorated polyetheretherketone
Abstract Polyetheretherketone (PEEK) is widely used in orthopedic and dental implants due to its excellent mechanical properties, chemical stability, and biocompatibility. However, its inherently bioinert nature makes it present weak osteogenic activity, which greatly restricts its clinical adoption...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-86561-3 |
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| author | Yongheng Zhang Lvhua Liu Mengqi Li Shufu Wang Jingjing Fu Mingyuan Yang Chunxi Yan Ying Liu Yanyan Zheng |
| author_facet | Yongheng Zhang Lvhua Liu Mengqi Li Shufu Wang Jingjing Fu Mingyuan Yang Chunxi Yan Ying Liu Yanyan Zheng |
| author_sort | Yongheng Zhang |
| collection | DOAJ |
| description | Abstract Polyetheretherketone (PEEK) is widely used in orthopedic and dental implants due to its excellent mechanical properties, chemical stability, and biocompatibility. However, its inherently bioinert nature makes it present weak osteogenic activity, which greatly restricts its clinical adoption. Herein, strontium (Sr) is incorporated onto the surface of PEEK using mussel-inspired polydopamine coating to improve its osteogenic activity. X-ray photoelectron spectroscopy and ion release assay results confirm that different concentrations of Sr are incorporated onto the PEEK substrate surfaces. The strontium-modified PEEK samples show a stable Sr ion release in 35 days of detection. Better results of MC3T3-E1 pre-osteoblasts adhesion, spreading, and proliferation can be observed in strontium-modified PEEK groups, which demonstrates strontium-modified PEEK samples with the improved MC3T3-E1 pre-osteoblasts compatibility. The boosted osteogenic activity of strontium-modified PEEK samples has been demonstrated by the better performed of ALP activity, extracellular matrix mineralization, collagen secretion, and the remarkable up-regulation of ALP, OCN, OPN, Runx2, Col-I, BSP, and OSX of the MC3T3-E1 pre-osteoblasts. Additionally, the strontium-modified PEEK samples exhibit a dose-dependent enhancement of osteoblasts compatibility and osteogenic activity, and the PEEK-Sr10 group shows the best. These findings indicate that strontium-decorated PEEK implants show promising application in orthopedic and dental implants. |
| format | Article |
| id | doaj-art-163e0b100fb44d608969838a51c8d90c |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-163e0b100fb44d608969838a51c8d90c2025-01-26T12:34:25ZengNature PortfolioScientific Reports2045-23222025-01-0115111310.1038/s41598-025-86561-3Dose-dependent enhancement of in vitro osteogenic activity on strontium-decorated polyetheretherketoneYongheng Zhang0Lvhua Liu1Mengqi Li2Shufu Wang3Jingjing Fu4Mingyuan Yang5Chunxi Yan6Ying Liu7Yanyan Zheng8Department of Stomatology, Affiliated Hospital of North Sichuan Medical CollegeSchool of Pharmacy, Medical Imaging Key Laboratory of Sichuan Province, North Sichuan Medical CollegeDepartment of Stomatology, Affiliated Hospital of North Sichuan Medical CollegeDepartment of Stomatology, North Sichuan Medical CollegeSchool of Pharmacy, Medical Imaging Key Laboratory of Sichuan Province, North Sichuan Medical CollegeSchool of Pharmacy, Medical Imaging Key Laboratory of Sichuan Province, North Sichuan Medical CollegeDepartment of Stomatology, North Sichuan Medical CollegeDepartment of Stomatology, Affiliated Hospital of North Sichuan Medical CollegeSchool of Pharmacy, Medical Imaging Key Laboratory of Sichuan Province, North Sichuan Medical CollegeAbstract Polyetheretherketone (PEEK) is widely used in orthopedic and dental implants due to its excellent mechanical properties, chemical stability, and biocompatibility. However, its inherently bioinert nature makes it present weak osteogenic activity, which greatly restricts its clinical adoption. Herein, strontium (Sr) is incorporated onto the surface of PEEK using mussel-inspired polydopamine coating to improve its osteogenic activity. X-ray photoelectron spectroscopy and ion release assay results confirm that different concentrations of Sr are incorporated onto the PEEK substrate surfaces. The strontium-modified PEEK samples show a stable Sr ion release in 35 days of detection. Better results of MC3T3-E1 pre-osteoblasts adhesion, spreading, and proliferation can be observed in strontium-modified PEEK groups, which demonstrates strontium-modified PEEK samples with the improved MC3T3-E1 pre-osteoblasts compatibility. The boosted osteogenic activity of strontium-modified PEEK samples has been demonstrated by the better performed of ALP activity, extracellular matrix mineralization, collagen secretion, and the remarkable up-regulation of ALP, OCN, OPN, Runx2, Col-I, BSP, and OSX of the MC3T3-E1 pre-osteoblasts. Additionally, the strontium-modified PEEK samples exhibit a dose-dependent enhancement of osteoblasts compatibility and osteogenic activity, and the PEEK-Sr10 group shows the best. These findings indicate that strontium-decorated PEEK implants show promising application in orthopedic and dental implants.https://doi.org/10.1038/s41598-025-86561-3PolyetheretherketoneOsteogenic activityStrontiumPolydopamineOrthopedic and dental implantSurface functionalization |
| spellingShingle | Yongheng Zhang Lvhua Liu Mengqi Li Shufu Wang Jingjing Fu Mingyuan Yang Chunxi Yan Ying Liu Yanyan Zheng Dose-dependent enhancement of in vitro osteogenic activity on strontium-decorated polyetheretherketone Scientific Reports Polyetheretherketone Osteogenic activity Strontium Polydopamine Orthopedic and dental implant Surface functionalization |
| title | Dose-dependent enhancement of in vitro osteogenic activity on strontium-decorated polyetheretherketone |
| title_full | Dose-dependent enhancement of in vitro osteogenic activity on strontium-decorated polyetheretherketone |
| title_fullStr | Dose-dependent enhancement of in vitro osteogenic activity on strontium-decorated polyetheretherketone |
| title_full_unstemmed | Dose-dependent enhancement of in vitro osteogenic activity on strontium-decorated polyetheretherketone |
| title_short | Dose-dependent enhancement of in vitro osteogenic activity on strontium-decorated polyetheretherketone |
| title_sort | dose dependent enhancement of in vitro osteogenic activity on strontium decorated polyetheretherketone |
| topic | Polyetheretherketone Osteogenic activity Strontium Polydopamine Orthopedic and dental implant Surface functionalization |
| url | https://doi.org/10.1038/s41598-025-86561-3 |
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