Antiviral Activity of the Marine Haptophyta <i>Diacronema lutheri</i>
There are still several viral infections affecting a considerable number of the world’s population, causing thousands of deaths each year. There are no drugs available for most viral infections and for many not even a vaccine. The marine kingdom is characterized by a huge chemical diversity; however...
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MDPI AG
2024-12-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/23/1/12 |
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| author | Eleonora Montuori Annalisa Ambrosino Gerardo Della Sala Costanza Ragozzino Gianluigi Franci Carla Zannella Anna De Filippis Donatella de Pascale Massimiliano Galdiero Chiara Lauritano |
| author_facet | Eleonora Montuori Annalisa Ambrosino Gerardo Della Sala Costanza Ragozzino Gianluigi Franci Carla Zannella Anna De Filippis Donatella de Pascale Massimiliano Galdiero Chiara Lauritano |
| author_sort | Eleonora Montuori |
| collection | DOAJ |
| description | There are still several viral infections affecting a considerable number of the world’s population, causing thousands of deaths each year. There are no drugs available for most viral infections and for many not even a vaccine. The marine kingdom is characterized by a huge chemical diversity; however, there is currently on the market only one drug derived from the sea with antiviral properties, called Ara-A. In the current study, we used a solid phase extraction method (SPE) to obtain pre-purified fractions from <i>Diacronema lutheri</i> raw extracts. We tested both raw extracts and fractions against enveloped and non-enveloped viruses. Results showed an antiviral activity of fraction C of <i>D. lutheri</i> against the herpes simplex virus type 1 (HSV-1 strain SC16). Liquid chromatography coupled with untargeted high-resolution tandem mass spectrometry (LC-HRMS<sup>2</sup>) were employed to chart the metabolite distribution in all SPE fractions and pinpoint molecular families unique (or almost unique) to the bioactive fraction. Sulfoquinovosyl di- and monoacylglycerols (SQDGs and SQMGs) and di- and monogalactosyl monoacylglycerols (DGMGs and MGMGs) represent the largest groups of compounds in fraction C and they are likely responsible for the antiviral properties of this fraction. |
| format | Article |
| id | doaj-art-163ad877d63f464f922cf6c52e8007ab |
| institution | Kabale University |
| issn | 1660-3397 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-163ad877d63f464f922cf6c52e8007ab2025-01-24T13:39:27ZengMDPI AGMarine Drugs1660-33972024-12-012311210.3390/md23010012Antiviral Activity of the Marine Haptophyta <i>Diacronema lutheri</i>Eleonora Montuori0Annalisa Ambrosino1Gerardo Della Sala2Costanza Ragozzino3Gianluigi Franci4Carla Zannella5Anna De Filippis6Donatella de Pascale7Massimiliano Galdiero8Chiara Lauritano9Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d’Alcontres 31, 98166 Messina, ItalyDepartment of Experimental Medicine, University of Campania “L.Vanvitelli”, Via De Crecchio, 7, 80138 Naples, ItalyEcosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via Acton 55, 80133 Napoli, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d’Alcontres 31, 98166 Messina, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Salerno, ItalyDepartment of Experimental Medicine, University of Campania “L.Vanvitelli”, Via De Crecchio, 7, 80138 Naples, ItalyDepartment of Experimental Medicine, University of Campania “L.Vanvitelli”, Via De Crecchio, 7, 80138 Naples, ItalyEcosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via Acton 55, 80133 Napoli, ItalyDepartment of Experimental Medicine, University of Campania “L.Vanvitelli”, Via De Crecchio, 7, 80138 Naples, ItalyEcosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via Acton 55, 80133 Napoli, ItalyThere are still several viral infections affecting a considerable number of the world’s population, causing thousands of deaths each year. There are no drugs available for most viral infections and for many not even a vaccine. The marine kingdom is characterized by a huge chemical diversity; however, there is currently on the market only one drug derived from the sea with antiviral properties, called Ara-A. In the current study, we used a solid phase extraction method (SPE) to obtain pre-purified fractions from <i>Diacronema lutheri</i> raw extracts. We tested both raw extracts and fractions against enveloped and non-enveloped viruses. Results showed an antiviral activity of fraction C of <i>D. lutheri</i> against the herpes simplex virus type 1 (HSV-1 strain SC16). Liquid chromatography coupled with untargeted high-resolution tandem mass spectrometry (LC-HRMS<sup>2</sup>) were employed to chart the metabolite distribution in all SPE fractions and pinpoint molecular families unique (or almost unique) to the bioactive fraction. Sulfoquinovosyl di- and monoacylglycerols (SQDGs and SQMGs) and di- and monogalactosyl monoacylglycerols (DGMGs and MGMGs) represent the largest groups of compounds in fraction C and they are likely responsible for the antiviral properties of this fraction.https://www.mdpi.com/1660-3397/23/1/12antiviral activity<i>Diacronema lutheri</i>anticancerglycerolipids |
| spellingShingle | Eleonora Montuori Annalisa Ambrosino Gerardo Della Sala Costanza Ragozzino Gianluigi Franci Carla Zannella Anna De Filippis Donatella de Pascale Massimiliano Galdiero Chiara Lauritano Antiviral Activity of the Marine Haptophyta <i>Diacronema lutheri</i> Marine Drugs antiviral activity <i>Diacronema lutheri</i> anticancer glycerolipids |
| title | Antiviral Activity of the Marine Haptophyta <i>Diacronema lutheri</i> |
| title_full | Antiviral Activity of the Marine Haptophyta <i>Diacronema lutheri</i> |
| title_fullStr | Antiviral Activity of the Marine Haptophyta <i>Diacronema lutheri</i> |
| title_full_unstemmed | Antiviral Activity of the Marine Haptophyta <i>Diacronema lutheri</i> |
| title_short | Antiviral Activity of the Marine Haptophyta <i>Diacronema lutheri</i> |
| title_sort | antiviral activity of the marine haptophyta i diacronema lutheri i |
| topic | antiviral activity <i>Diacronema lutheri</i> anticancer glycerolipids |
| url | https://www.mdpi.com/1660-3397/23/1/12 |
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