A Simple Matter of Life and Death—The Trials of Postnatal Beta-Cell Mass Regulation
Pancreatic beta-cells, which secrete the hormone insulin, are the key arbiters of glucose homeostasis. Defective beta-cell numbers and/or function underlie essentially all major forms of diabetes and must be restored if diabetes is to be cured. Thus, the identification of the molecular regulators o...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/516718 |
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| author | Elena Tarabra Stella Pelengaris Michael Khan |
| author_facet | Elena Tarabra Stella Pelengaris Michael Khan |
| author_sort | Elena Tarabra |
| collection | DOAJ |
| description | Pancreatic beta-cells, which secrete the hormone insulin, are the key arbiters of glucose homeostasis. Defective beta-cell numbers and/or function underlie essentially all major forms of diabetes and must be restored if diabetes is to be cured. Thus, the identification of the molecular regulators of beta-cell mass and a better understanding of the processes of beta-cell differentiation and proliferation may provide further insight for the development of new therapeutic targets for diabetes.
This review will focus on the principal hormones and nutrients, as well as downstream signalling pathways regulating beta-cell mass in the adult. Furthermore, we will also address more recently appreciated regulators of beta-cell mass, such as microRNAs. |
| format | Article |
| id | doaj-art-16376889ce934677b5348a0aeb5dbb0e |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-16376889ce934677b5348a0aeb5dbb0e2025-02-03T05:50:13ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/516718516718A Simple Matter of Life and Death—The Trials of Postnatal Beta-Cell Mass RegulationElena Tarabra0Stella Pelengaris1Michael Khan2School of Life Sciences, Warwick University, Gibbet Hill Road, Coventry CV4 7AL, UKSchool of Life Sciences, Warwick University, Gibbet Hill Road, Coventry CV4 7AL, UKSchool of Life Sciences, Warwick University, Gibbet Hill Road, Coventry CV4 7AL, UKPancreatic beta-cells, which secrete the hormone insulin, are the key arbiters of glucose homeostasis. Defective beta-cell numbers and/or function underlie essentially all major forms of diabetes and must be restored if diabetes is to be cured. Thus, the identification of the molecular regulators of beta-cell mass and a better understanding of the processes of beta-cell differentiation and proliferation may provide further insight for the development of new therapeutic targets for diabetes. This review will focus on the principal hormones and nutrients, as well as downstream signalling pathways regulating beta-cell mass in the adult. Furthermore, we will also address more recently appreciated regulators of beta-cell mass, such as microRNAs.http://dx.doi.org/10.1155/2012/516718 |
| spellingShingle | Elena Tarabra Stella Pelengaris Michael Khan A Simple Matter of Life and Death—The Trials of Postnatal Beta-Cell Mass Regulation International Journal of Endocrinology |
| title | A Simple Matter of Life and Death—The Trials of Postnatal Beta-Cell Mass Regulation |
| title_full | A Simple Matter of Life and Death—The Trials of Postnatal Beta-Cell Mass Regulation |
| title_fullStr | A Simple Matter of Life and Death—The Trials of Postnatal Beta-Cell Mass Regulation |
| title_full_unstemmed | A Simple Matter of Life and Death—The Trials of Postnatal Beta-Cell Mass Regulation |
| title_short | A Simple Matter of Life and Death—The Trials of Postnatal Beta-Cell Mass Regulation |
| title_sort | simple matter of life and death the trials of postnatal beta cell mass regulation |
| url | http://dx.doi.org/10.1155/2012/516718 |
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