Clinical spectrum of disease and outcomes in children with Omicron SARS-COV-2 infection in Cape Town, South Africa
INTRODUCTION: Children with underlying comorbidities and infants are most severely affected by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, including in low- and middle-income countries with a high prevalence of HIV and TB. We describe the clinical presentation of SARS-CoV...
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International Union Against Tuberculosis and Lung Disease (The Union)
2024-01-01
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| Series: | IJTLD Open |
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| author | C. Bekker I. Dewandel A. Redfern C. McKenzie J. Lishman L. M. Verhagen M. Claassen S. Wilson R. Dunbar C. Bosch G. van Zyl W. Preiser P. Goussard H. Rabie M. M. van der Zalm |
| author_facet | C. Bekker I. Dewandel A. Redfern C. McKenzie J. Lishman L. M. Verhagen M. Claassen S. Wilson R. Dunbar C. Bosch G. van Zyl W. Preiser P. Goussard H. Rabie M. M. van der Zalm |
| author_sort | C. Bekker |
| collection | DOAJ |
| description | INTRODUCTION: Children with underlying comorbidities and infants are most severely affected by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, including in low- and middle-income countries with a high prevalence of HIV and TB. We describe the clinical presentation of SARS-CoV-2 infection in children during the Omicron wave, in Cape Town, South Africa. METHODS: We analysed routine care data from a prospective cohort of children aged 0–13 years, with a positive SARS-CoV-2 real-time reverse-transcription polymerase chain reaction (rRT-PCR) or SARS-CoV-2 antigen test, admitted to Tygerberg Hospital between 1 November 2021 until 1 March 2022. Risk factors for severity of disease were assessed. RESULTS: Ninety-five children tested positive for SARS-CoV-2, of whom 87 (91.6%) were symptomatic. Clinical data were available for 86 children. The median age was 11 months (IQR 3.0–60.0), 37 (43.0%) were females, 21 (24.7%) were HIV-exposed and 7 (8.1%) were living with HIV (CLHIV). In total, 44 (51.2%) children had at least one underlying comorbidity. TB co-infection was seen in 11 children, 6 children were newly diagnosed and 5 children were already on TB treatment at the time of admission. CONCLUSION: There was no evidence of more severe disease in children living with HIV or TB. |
| format | Article |
| id | doaj-art-16357641ad204ae7a48c240d17534262 |
| institution | Kabale University |
| issn | 3005-7590 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | International Union Against Tuberculosis and Lung Disease (The Union) |
| record_format | Article |
| series | IJTLD Open |
| spelling | doaj-art-16357641ad204ae7a48c240d175342622025-01-21T09:59:34ZengInternational Union Against Tuberculosis and Lung Disease (The Union)IJTLD Open3005-75902024-01-0111273310.5588/ijtldopen.23.00536Clinical spectrum of disease and outcomes in children with Omicron SARS-COV-2 infection in Cape Town, South AfricaC. Bekker0I. Dewandel1A. Redfern2C. McKenzie3J. Lishman4L. M. Verhagen5M. Claassen6S. Wilson7R. Dunbar8C. Bosch9G. van Zyl10W. Preiser11P. Goussard12H. Rabie13M. M. van der Zalm14Desmond Tutu TB Centre, andDesmond Tutu TB Centre, andDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaDesmond Tutu TB Centre, andDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaDivision of Medical Virology, Stellenbosch University, Cape TownDesmond Tutu TB Centre, andDesmond Tutu TB Centre, andDesmond Tutu TB Centre, andDivision of Medical Virology, Stellenbosch University, Cape TownDivision of Medical Virology, Stellenbosch University, Cape TownDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaDesmond Tutu TB Centre, andINTRODUCTION: Children with underlying comorbidities and infants are most severely affected by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, including in low- and middle-income countries with a high prevalence of HIV and TB. We describe the clinical presentation of SARS-CoV-2 infection in children during the Omicron wave, in Cape Town, South Africa. METHODS: We analysed routine care data from a prospective cohort of children aged 0–13 years, with a positive SARS-CoV-2 real-time reverse-transcription polymerase chain reaction (rRT-PCR) or SARS-CoV-2 antigen test, admitted to Tygerberg Hospital between 1 November 2021 until 1 March 2022. Risk factors for severity of disease were assessed. RESULTS: Ninety-five children tested positive for SARS-CoV-2, of whom 87 (91.6%) were symptomatic. Clinical data were available for 86 children. The median age was 11 months (IQR 3.0–60.0), 37 (43.0%) were females, 21 (24.7%) were HIV-exposed and 7 (8.1%) were living with HIV (CLHIV). In total, 44 (51.2%) children had at least one underlying comorbidity. TB co-infection was seen in 11 children, 6 children were newly diagnosed and 5 children were already on TB treatment at the time of admission. CONCLUSION: There was no evidence of more severe disease in children living with HIV or TB.https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000001/art00006omicrontuberculosischildren living with hivcomorbiditiespaediatric |
| spellingShingle | C. Bekker I. Dewandel A. Redfern C. McKenzie J. Lishman L. M. Verhagen M. Claassen S. Wilson R. Dunbar C. Bosch G. van Zyl W. Preiser P. Goussard H. Rabie M. M. van der Zalm Clinical spectrum of disease and outcomes in children with Omicron SARS-COV-2 infection in Cape Town, South Africa IJTLD Open omicron tuberculosis children living with hiv comorbidities paediatric |
| title | Clinical spectrum of disease and outcomes in children with Omicron SARS-COV-2 infection in Cape Town, South Africa |
| title_full | Clinical spectrum of disease and outcomes in children with Omicron SARS-COV-2 infection in Cape Town, South Africa |
| title_fullStr | Clinical spectrum of disease and outcomes in children with Omicron SARS-COV-2 infection in Cape Town, South Africa |
| title_full_unstemmed | Clinical spectrum of disease and outcomes in children with Omicron SARS-COV-2 infection in Cape Town, South Africa |
| title_short | Clinical spectrum of disease and outcomes in children with Omicron SARS-COV-2 infection in Cape Town, South Africa |
| title_sort | clinical spectrum of disease and outcomes in children with omicron sars cov 2 infection in cape town south africa |
| topic | omicron tuberculosis children living with hiv comorbidities paediatric |
| url | https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000001/art00006 |
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