Bivalirudin vs. Heparin on Radial Artery Thrombosis during Transradial Coronary Intervention: An Optical Coherence Tomography Study
Objectives. This study aimed to evaluate the antithrombotic efficacy between bivalirudin and unfractionated heparin (UFH) on radial artery thrombosis (RAT) during transradial coronary intervention (TRI) by optical coherence tomography (OCT). Methods and Results. We consecutively reviewed a total of...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Interventional Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2020/7905021 |
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| author | Zijing Liu Guozhong Wang Dan Niu Yongxia Wu Zixuan Li Libin Zhang Guohua Zhu Qi Hua Jincheng Guo |
| author_facet | Zijing Liu Guozhong Wang Dan Niu Yongxia Wu Zixuan Li Libin Zhang Guohua Zhu Qi Hua Jincheng Guo |
| author_sort | Zijing Liu |
| collection | DOAJ |
| description | Objectives. This study aimed to evaluate the antithrombotic efficacy between bivalirudin and unfractionated heparin (UFH) on radial artery thrombosis (RAT) during transradial coronary intervention (TRI) by optical coherence tomography (OCT). Methods and Results. We consecutively reviewed a total of 307 patients who underwent radial artery OCT inspection after TRI in our centre from October 2017 to January 2019; afterwards, 211 screened patients were divided into the UFH group (n = 144) and the bivalirudin group (n = 67) according to their anticoagulation strategy during TRI. The thrombosis in the radial artery was observed in 51 cases (24.17%) with a median thrombus volume of 0.054 mm3 (0.024, 0.334) and median thrombus score of 7 (4, 15). Thrombus occurred in 28 cases in the bivalirudin group with an incidence of 41.8%, which was significantly higher than that in the UFH group (n = 23, 16.0%, P<0.001). This difference was even more remarkable after propensity score matching (bivalirudin group n = 22, 42.3% vs. UHF group n = 11, 13.9%, P<0.001). Multivariate logistic analysis revealed that bivalirudin increased the RAT risk by 3.872 times (95% CI 2.006–8.354, P<0.001) after adjustment for the other predictors. Conclusion. In this present study, the use of bivalirudin was associated with a higher risk of RAT than UFH. It highlighted UFH should be a more considerable choice to prevent radial artery access thrombosis in TRI. |
| format | Article |
| id | doaj-art-162bfbc1ac504815b0c7f338eebd9788 |
| institution | Kabale University |
| issn | 0896-4327 1540-8183 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Interventional Cardiology |
| spelling | doaj-art-162bfbc1ac504815b0c7f338eebd97882025-02-03T06:46:34ZengWileyJournal of Interventional Cardiology0896-43271540-81832020-01-01202010.1155/2020/79050217905021Bivalirudin vs. Heparin on Radial Artery Thrombosis during Transradial Coronary Intervention: An Optical Coherence Tomography StudyZijing Liu0Guozhong Wang1Dan Niu2Yongxia Wu3Zixuan Li4Libin Zhang5Guohua Zhu6Qi Hua7Jincheng Guo8Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 10000, ChinaDepartment of Cardiology, Beijing Luhe Hospital, Capital Medical University, Beijing 100000, ChinaDepartment of Cardiology, Beijing Luhe Hospital, Capital Medical University, Beijing 100000, ChinaDepartment of Cardiology, Beijing Luhe Hospital, Capital Medical University, Beijing 100000, ChinaDepartment of Cardiology, Beijing Luhe Hospital, Capital Medical University, Beijing 100000, ChinaDepartment of Cardiology, Beijing Luhe Hospital, Capital Medical University, Beijing 100000, ChinaDepartment of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 10000, ChinaDepartment of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 10000, ChinaDepartment of Cardiology, Beijing Luhe Hospital, Capital Medical University, Beijing 100000, ChinaObjectives. This study aimed to evaluate the antithrombotic efficacy between bivalirudin and unfractionated heparin (UFH) on radial artery thrombosis (RAT) during transradial coronary intervention (TRI) by optical coherence tomography (OCT). Methods and Results. We consecutively reviewed a total of 307 patients who underwent radial artery OCT inspection after TRI in our centre from October 2017 to January 2019; afterwards, 211 screened patients were divided into the UFH group (n = 144) and the bivalirudin group (n = 67) according to their anticoagulation strategy during TRI. The thrombosis in the radial artery was observed in 51 cases (24.17%) with a median thrombus volume of 0.054 mm3 (0.024, 0.334) and median thrombus score of 7 (4, 15). Thrombus occurred in 28 cases in the bivalirudin group with an incidence of 41.8%, which was significantly higher than that in the UFH group (n = 23, 16.0%, P<0.001). This difference was even more remarkable after propensity score matching (bivalirudin group n = 22, 42.3% vs. UHF group n = 11, 13.9%, P<0.001). Multivariate logistic analysis revealed that bivalirudin increased the RAT risk by 3.872 times (95% CI 2.006–8.354, P<0.001) after adjustment for the other predictors. Conclusion. In this present study, the use of bivalirudin was associated with a higher risk of RAT than UFH. It highlighted UFH should be a more considerable choice to prevent radial artery access thrombosis in TRI.http://dx.doi.org/10.1155/2020/7905021 |
| spellingShingle | Zijing Liu Guozhong Wang Dan Niu Yongxia Wu Zixuan Li Libin Zhang Guohua Zhu Qi Hua Jincheng Guo Bivalirudin vs. Heparin on Radial Artery Thrombosis during Transradial Coronary Intervention: An Optical Coherence Tomography Study Journal of Interventional Cardiology |
| title | Bivalirudin vs. Heparin on Radial Artery Thrombosis during Transradial Coronary Intervention: An Optical Coherence Tomography Study |
| title_full | Bivalirudin vs. Heparin on Radial Artery Thrombosis during Transradial Coronary Intervention: An Optical Coherence Tomography Study |
| title_fullStr | Bivalirudin vs. Heparin on Radial Artery Thrombosis during Transradial Coronary Intervention: An Optical Coherence Tomography Study |
| title_full_unstemmed | Bivalirudin vs. Heparin on Radial Artery Thrombosis during Transradial Coronary Intervention: An Optical Coherence Tomography Study |
| title_short | Bivalirudin vs. Heparin on Radial Artery Thrombosis during Transradial Coronary Intervention: An Optical Coherence Tomography Study |
| title_sort | bivalirudin vs heparin on radial artery thrombosis during transradial coronary intervention an optical coherence tomography study |
| url | http://dx.doi.org/10.1155/2020/7905021 |
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