Interaction effect between overweight/obesity and alcohol consumption on hypertension risk in China: a longitudinal study
Objective To explore the interaction effect between overweight/obesity and alcohol consumption on hypertension risk.Design A longitudinal study of the independent and combined effects of hypertension risk factors.Setting Twelve provinces in China, including Beijing Liaoning, Heilongjiang, Shanghai,...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-07-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/7/e061261.full |
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| author | Xiaoqin Wang Zhaozhao Hui Jiaru Sun Paul D Terry Xiaohan Ren Shuangyan Lei Caihua Wang Mingxu Wang |
| author_facet | Xiaoqin Wang Zhaozhao Hui Jiaru Sun Paul D Terry Xiaohan Ren Shuangyan Lei Caihua Wang Mingxu Wang |
| author_sort | Xiaoqin Wang |
| collection | DOAJ |
| description | Objective To explore the interaction effect between overweight/obesity and alcohol consumption on hypertension risk.Design A longitudinal study of the independent and combined effects of hypertension risk factors.Setting Twelve provinces in China, including Beijing Liaoning, Heilongjiang, Shanghai, Jiangsu, Shandong, Henan, Hubei, Hunan, Guangxi, Guizhou and Chongqing.Participants Longitudinal data of China Health and Nutrition Survey, collected between 2011 and 2015, were used in this study. A total of 13 121 residents from 12 provinces were included and completed physical examinations and questionnaires at baseline.Outcome First incidence of hypertension.Results Over a mean follow-up of 4 years, 690 incident hypertension cases were reported. After adjusting for age, gender, education level, marital status, physical activity, diabetes and smoking, high body mass index (BMI) and light drinking (OR=5.07, 95% CI 3.06 to 8.41), high waist circumference (WC) and light drinking (OR=4.81, 95% CI 2.92 to 7.91), high waist hip ratio and light drinking (OR=2.85, 95% CI 1.84 to 4.42) were the highest risk of all participants in the three combinations. Multiplicative interaction measures were statistically significant in overweight/obesity and drinking/light drinking/heavy drinking categories in men (p<0.05). Additive interactions were observed between high BMI and drinking in men (relative excess risk due to interaction=1.75, 95% CI 0.85 to 2.65, attributable proportion due to interaction=0.56, 95% CI 0.36 to 0.76, synergy index=6.43, 95% CI 1.02 to 28.84).Conclusions Measures of body weight and size, particularly BMI and WC, appear to interact synergistically with alcohol consumption to increase the risk of hypertension in the Chinese population. Given that approximately 245 million people in China have hypertension, and that hypertension is a major cause of cardiovascular disease worldwide, our results may have implications for chronic disease prevention. |
| format | Article |
| id | doaj-art-16254f7aeba54524b09deaf84c020dcd |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-16254f7aeba54524b09deaf84c020dcd2025-01-30T15:25:09ZengBMJ Publishing GroupBMJ Open2044-60552022-07-0112710.1136/bmjopen-2022-061261Interaction effect between overweight/obesity and alcohol consumption on hypertension risk in China: a longitudinal studyXiaoqin Wang0Zhaozhao Hui1Jiaru Sun2Paul D Terry3Xiaohan Ren4Shuangyan Lei5Caihua Wang6Mingxu Wang7Department of Nursing, Xi`an Jiaotong University Health Science Center, Xi`an, Shaanxi, China2 School of Public Health, Xi`an Jiaotong University, Xi`an, Shaanxi, ChinaDepartment of Nursing, Xi`an Jiaotong University Health Science Center, Xi`an, Shaanxi, ChinaGraduate School of Medicine, University of Tennessee Medical Center, Knoxville, Tennessee, USADepartment of Nursing, Xi`an Jiaotong University Health Science Center, Xi`an, Shaanxi, ChinaDepartment of Radiotherapy, Shaanxi Provincial Cancer Hospital, Xi`an, Shaanxi, ChinaDepartment of Nursing, Xi`an Jiaotong University Health Science Center, Xi`an, Shaanxi, ChinaSchool of Public Health, Xi`an Jiaotong University Health Science Center, Xi`an, Shaanxi, ChinaObjective To explore the interaction effect between overweight/obesity and alcohol consumption on hypertension risk.Design A longitudinal study of the independent and combined effects of hypertension risk factors.Setting Twelve provinces in China, including Beijing Liaoning, Heilongjiang, Shanghai, Jiangsu, Shandong, Henan, Hubei, Hunan, Guangxi, Guizhou and Chongqing.Participants Longitudinal data of China Health and Nutrition Survey, collected between 2011 and 2015, were used in this study. A total of 13 121 residents from 12 provinces were included and completed physical examinations and questionnaires at baseline.Outcome First incidence of hypertension.Results Over a mean follow-up of 4 years, 690 incident hypertension cases were reported. After adjusting for age, gender, education level, marital status, physical activity, diabetes and smoking, high body mass index (BMI) and light drinking (OR=5.07, 95% CI 3.06 to 8.41), high waist circumference (WC) and light drinking (OR=4.81, 95% CI 2.92 to 7.91), high waist hip ratio and light drinking (OR=2.85, 95% CI 1.84 to 4.42) were the highest risk of all participants in the three combinations. Multiplicative interaction measures were statistically significant in overweight/obesity and drinking/light drinking/heavy drinking categories in men (p<0.05). Additive interactions were observed between high BMI and drinking in men (relative excess risk due to interaction=1.75, 95% CI 0.85 to 2.65, attributable proportion due to interaction=0.56, 95% CI 0.36 to 0.76, synergy index=6.43, 95% CI 1.02 to 28.84).Conclusions Measures of body weight and size, particularly BMI and WC, appear to interact synergistically with alcohol consumption to increase the risk of hypertension in the Chinese population. Given that approximately 245 million people in China have hypertension, and that hypertension is a major cause of cardiovascular disease worldwide, our results may have implications for chronic disease prevention.https://bmjopen.bmj.com/content/12/7/e061261.full |
| spellingShingle | Xiaoqin Wang Zhaozhao Hui Jiaru Sun Paul D Terry Xiaohan Ren Shuangyan Lei Caihua Wang Mingxu Wang Interaction effect between overweight/obesity and alcohol consumption on hypertension risk in China: a longitudinal study BMJ Open |
| title | Interaction effect between overweight/obesity and alcohol consumption on hypertension risk in China: a longitudinal study |
| title_full | Interaction effect between overweight/obesity and alcohol consumption on hypertension risk in China: a longitudinal study |
| title_fullStr | Interaction effect between overweight/obesity and alcohol consumption on hypertension risk in China: a longitudinal study |
| title_full_unstemmed | Interaction effect between overweight/obesity and alcohol consumption on hypertension risk in China: a longitudinal study |
| title_short | Interaction effect between overweight/obesity and alcohol consumption on hypertension risk in China: a longitudinal study |
| title_sort | interaction effect between overweight obesity and alcohol consumption on hypertension risk in china a longitudinal study |
| url | https://bmjopen.bmj.com/content/12/7/e061261.full |
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