ASSOCIATIONS OF INTERFERON GENE POLYMORPHISMS OAS-1, OAS-3, PKR WITH CHRONIC VIRAL HEPATITIS C
Abstract. Present work is devoted to analyzing possible associations of single-nucleotide gene polymorphisms (SNPs) with liver pathology in patients with chronic hepatitis C. SNP genotypes and allele frequencies were identified for some genes of interferon system, i.e., oligoadenilatsynthetase-1 (-1...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/266 |
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| author | V. A. Bychkov N. V. Ryazantseva V. V. Novitskiy N. A. Semenova L. A. Kleptsova V. D. Yakushina |
| author_facet | V. A. Bychkov N. V. Ryazantseva V. V. Novitskiy N. A. Semenova L. A. Kleptsova V. D. Yakushina |
| author_sort | V. A. Bychkov |
| collection | DOAJ |
| description | Abstract. Present work is devoted to analyzing possible associations of single-nucleotide gene polymorphisms (SNPs) with liver pathology in patients with chronic hepatitis C. SNP genotypes and allele frequencies were identified for some genes of interferon system, i.e., oligoadenilatsynthetase-1 (-1A/G), oligoadenilatsynthetase-3 (+1314C/T), and protein kinase R (+244A/G), using DNA samples from healthy donors and patients with chronic hepatitis C representing population of Tomsk and Tomsk Region. An association has been shown between SNPs of oligoadenilatsynthetase-1 and protein kinase R genes, and clinical activity of inflammatory process in the liver, as well as an impact of certain SNPs of protein kinase R and oligoadenilatsynthetase-3 genes upon fibrogenesis. (Med. Immunol., 2011, vol. 13, N 1, pp 93-100) |
| format | Article |
| id | doaj-art-1623ebfae9f34061ba7fcb2b13f28aab |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-1623ebfae9f34061ba7fcb2b13f28aab2025-08-20T03:44:08ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-011319310010.15789/1563-0625-2011-1-93-100263ASSOCIATIONS OF INTERFERON GENE POLYMORPHISMS OAS-1, OAS-3, PKR WITH CHRONIC VIRAL HEPATITIS CV. A. Bychkov0N. V. Ryazantseva1V. V. Novitskiy2N. A. Semenova3L. A. Kleptsova4V. D. Yakushina5ГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскAbstract. Present work is devoted to analyzing possible associations of single-nucleotide gene polymorphisms (SNPs) with liver pathology in patients with chronic hepatitis C. SNP genotypes and allele frequencies were identified for some genes of interferon system, i.e., oligoadenilatsynthetase-1 (-1A/G), oligoadenilatsynthetase-3 (+1314C/T), and protein kinase R (+244A/G), using DNA samples from healthy donors and patients with chronic hepatitis C representing population of Tomsk and Tomsk Region. An association has been shown between SNPs of oligoadenilatsynthetase-1 and protein kinase R genes, and clinical activity of inflammatory process in the liver, as well as an impact of certain SNPs of protein kinase R and oligoadenilatsynthetase-3 genes upon fibrogenesis. (Med. Immunol., 2011, vol. 13, N 1, pp 93-100)https://www.mimmun.ru/mimmun/article/view/266chronic hepatitis cfibrosisoligoadenilatsynthetase-1oligoadenilatsynthetase-3protein kinase r |
| spellingShingle | V. A. Bychkov N. V. Ryazantseva V. V. Novitskiy N. A. Semenova L. A. Kleptsova V. D. Yakushina ASSOCIATIONS OF INTERFERON GENE POLYMORPHISMS OAS-1, OAS-3, PKR WITH CHRONIC VIRAL HEPATITIS C Медицинская иммунология chronic hepatitis c fibrosis oligoadenilatsynthetase-1 oligoadenilatsynthetase-3 protein kinase r |
| title | ASSOCIATIONS OF INTERFERON GENE POLYMORPHISMS OAS-1, OAS-3, PKR WITH CHRONIC VIRAL HEPATITIS C |
| title_full | ASSOCIATIONS OF INTERFERON GENE POLYMORPHISMS OAS-1, OAS-3, PKR WITH CHRONIC VIRAL HEPATITIS C |
| title_fullStr | ASSOCIATIONS OF INTERFERON GENE POLYMORPHISMS OAS-1, OAS-3, PKR WITH CHRONIC VIRAL HEPATITIS C |
| title_full_unstemmed | ASSOCIATIONS OF INTERFERON GENE POLYMORPHISMS OAS-1, OAS-3, PKR WITH CHRONIC VIRAL HEPATITIS C |
| title_short | ASSOCIATIONS OF INTERFERON GENE POLYMORPHISMS OAS-1, OAS-3, PKR WITH CHRONIC VIRAL HEPATITIS C |
| title_sort | associations of interferon gene polymorphisms oas 1 oas 3 pkr with chronic viral hepatitis c |
| topic | chronic hepatitis c fibrosis oligoadenilatsynthetase-1 oligoadenilatsynthetase-3 protein kinase r |
| url | https://www.mimmun.ru/mimmun/article/view/266 |
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