Tofacitinib and budesonide treatment affect stemness and chemokine release in IBD patient-derived colonoids

Tofacitinib and budesonide treatment affect stemness and chemokine release in IBD patient-derived colonoids

Abstract Restoration of the intestinal epithelial barrier is crucial for achieving mucosal healing, the therapeutic goal for inflammatory bowel disease (IBD). During homeostasis, epithelial renewal is maintained by crypt stem cells and progenitors that cease to divide as they differentiate into matu...

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Main Authors: Arun Sridhar, Ingunn Bakke, Shreya Gopalakrishnan, Nimo Mukhtar Mohamud Osoble, Emilie Prytz Hammarqvist, Henrik P. Sahlin Pettersen, Arne Kristian Sandvik, Ann Elisabet Østvik, Marianne Doré Hansen, Torunn Bruland
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Intestinal epithelium
Organoids
JAK-inhibitor
Online Access:https://doi.org/10.1038/s41598-025-86314-2
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