Neural mechanisms of non-pharmacological interventions in patients with mild cognitive impairment and Alzheimer's disease: An ALE meta-analysis
Non-pharmacologic interventions are effective for persons showing mild cognitive impairment (MCI) and Alzheimer's disease (AD). We used activation likelihood estimation (ALE) meta-analysis to systematically quantify the results of 19 neuroimaging studies in order to identify brain regions in wh...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Experimental Gerontology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556525000063 |
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| author | Ning Wang Jinkun Li Yunxiao Guo Panbing Zhang Fulin You Ziyi Wang Zhonghuan Wang Xiaobin Hong |
| author_facet | Ning Wang Jinkun Li Yunxiao Guo Panbing Zhang Fulin You Ziyi Wang Zhonghuan Wang Xiaobin Hong |
| author_sort | Ning Wang |
| collection | DOAJ |
| description | Non-pharmacologic interventions are effective for persons showing mild cognitive impairment (MCI) and Alzheimer's disease (AD). We used activation likelihood estimation (ALE) meta-analysis to systematically quantify the results of 19 neuroimaging studies in order to identify brain regions in which patients showed stable increases or decreases in activation after interventions. We also tested the moderating effects of disease stage (MCI vs. AD) and intervention modality (cognitive training vs. exercise intervention). The results showed increased activation in the cuneus, precuneus and medial frontal gyrus in the combined groups after treatment, whereas the anterior cingulate gyrus showed decreased activation. Secondly, in the MCI group there was increased activation in the precuneus and precentral gyrus after treatment, whereas there was decreased activation in the anterior cingulate gyrus; in the AD group there was only increased activation after treatment, including in the lingual gyrus and bilateral superior temporal gyrus. Finally, the bilateral cuneus and precentral gyrus showed increased activation after cognitive training, while bilateral insula, among others, showed decreased activation. This suggests that there are brain activation changes after non-pharmacological treatments for MCI and AD patients, but that the treatment mechanisms are moderated by stage and intervention modality. Future studies could continue to explore specific neural mechanisms involved in different intervention conditions for these patients. |
| format | Article |
| id | doaj-art-16236cc92d1448cea6cc9ef6d64ce094 |
| institution | Kabale University |
| issn | 1873-6815 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj-art-16236cc92d1448cea6cc9ef6d64ce0942025-01-31T05:10:08ZengElsevierExperimental Gerontology1873-68152025-02-01200112678Neural mechanisms of non-pharmacological interventions in patients with mild cognitive impairment and Alzheimer's disease: An ALE meta-analysisNing Wang0Jinkun Li1Yunxiao Guo2Panbing Zhang3Fulin You4Ziyi Wang5Zhonghuan Wang6Xiaobin Hong7Department of Psychology, Wuhan Sports University, Wuhan, ChinaSchool of Physical Education and Sports, Central China Normal University, Wuhan, ChinaSchool of Psychology, Central China Normal University, Wuhan, ChinaSchool of Sports Medicine, Wuhan Sports University, Wuhan, ChinaDepartment of Psychology, Wuhan Sports University, Wuhan, ChinaDepartment of Psychology, Wuhan Sports University, Wuhan, ChinaDepartment of Psychology, Wuhan Sports University, Wuhan, ChinaDepartment of Psychology, Wuhan Sports University, Wuhan, China; Hubei Key Laboratory of Exercise Training and Monitoring, School of Sports Medicine, Wuhan Sports University, Wuhan, China; Corresponding author at: Department of Psychology, Wuhan Sports University, Wuhan 430079, China.Non-pharmacologic interventions are effective for persons showing mild cognitive impairment (MCI) and Alzheimer's disease (AD). We used activation likelihood estimation (ALE) meta-analysis to systematically quantify the results of 19 neuroimaging studies in order to identify brain regions in which patients showed stable increases or decreases in activation after interventions. We also tested the moderating effects of disease stage (MCI vs. AD) and intervention modality (cognitive training vs. exercise intervention). The results showed increased activation in the cuneus, precuneus and medial frontal gyrus in the combined groups after treatment, whereas the anterior cingulate gyrus showed decreased activation. Secondly, in the MCI group there was increased activation in the precuneus and precentral gyrus after treatment, whereas there was decreased activation in the anterior cingulate gyrus; in the AD group there was only increased activation after treatment, including in the lingual gyrus and bilateral superior temporal gyrus. Finally, the bilateral cuneus and precentral gyrus showed increased activation after cognitive training, while bilateral insula, among others, showed decreased activation. This suggests that there are brain activation changes after non-pharmacological treatments for MCI and AD patients, but that the treatment mechanisms are moderated by stage and intervention modality. Future studies could continue to explore specific neural mechanisms involved in different intervention conditions for these patients.http://www.sciencedirect.com/science/article/pii/S0531556525000063Mild cognitive impairment (MCI)Alzheimer's disease (AD)Non-pharmacological interventionsActivation likelihood estimationNeural mechanismsNeuroimaging |
| spellingShingle | Ning Wang Jinkun Li Yunxiao Guo Panbing Zhang Fulin You Ziyi Wang Zhonghuan Wang Xiaobin Hong Neural mechanisms of non-pharmacological interventions in patients with mild cognitive impairment and Alzheimer's disease: An ALE meta-analysis Experimental Gerontology Mild cognitive impairment (MCI) Alzheimer's disease (AD) Non-pharmacological interventions Activation likelihood estimation Neural mechanisms Neuroimaging |
| title | Neural mechanisms of non-pharmacological interventions in patients with mild cognitive impairment and Alzheimer's disease: An ALE meta-analysis |
| title_full | Neural mechanisms of non-pharmacological interventions in patients with mild cognitive impairment and Alzheimer's disease: An ALE meta-analysis |
| title_fullStr | Neural mechanisms of non-pharmacological interventions in patients with mild cognitive impairment and Alzheimer's disease: An ALE meta-analysis |
| title_full_unstemmed | Neural mechanisms of non-pharmacological interventions in patients with mild cognitive impairment and Alzheimer's disease: An ALE meta-analysis |
| title_short | Neural mechanisms of non-pharmacological interventions in patients with mild cognitive impairment and Alzheimer's disease: An ALE meta-analysis |
| title_sort | neural mechanisms of non pharmacological interventions in patients with mild cognitive impairment and alzheimer s disease an ale meta analysis |
| topic | Mild cognitive impairment (MCI) Alzheimer's disease (AD) Non-pharmacological interventions Activation likelihood estimation Neural mechanisms Neuroimaging |
| url | http://www.sciencedirect.com/science/article/pii/S0531556525000063 |
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