Histopathological Study of Cyclosporine Pulmonary Toxicity in Rats
Cyclosporine is considered one of the common worldwide immunosuppressive drugs that are used for allograft rejection prevention. However, articles that address adverse effects of cyclosporine use on the vital organs such as lung are still few. This study aims to investigate pulmonary toxic effect of...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2016/2973274 |
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| author | Said Said Elshama Ayman El-Meghawry EL-Kenawy Hosam-Eldin Hussein Osman |
| author_facet | Said Said Elshama Ayman El-Meghawry EL-Kenawy Hosam-Eldin Hussein Osman |
| author_sort | Said Said Elshama |
| collection | DOAJ |
| description | Cyclosporine is considered one of the common worldwide immunosuppressive drugs that are used for allograft rejection prevention. However, articles that address adverse effects of cyclosporine use on the vital organs such as lung are still few. This study aims to investigate pulmonary toxic effect of cyclosporine in rats by assessment of pulmonary histopathological changes using light and electron microscope examination. Sixty male adult albino rats were divided into three groups; each group consists of twenty rats. The first received physiological saline while the second and third groups received 25 and 40 mg/kg/day of cyclosporine, respectively, by gastric gavage for forty-five days. Cyclosporine reduced the lung and body weight with shrinkage or pyknotic nucleus of pneumocyte type II, degeneration of alveoli and interalveolar septum beside microvilli on the alveolar surface, emphysema, inflammatory cellular infiltration, pulmonary blood vessels congestion, and increase of fibrous tissues in the interstitial tissues and around alveoli with negative Periodic Acid-Schiff staining. Prolonged use of cyclosporine induced pulmonary ultrastructural and histopathological changes with the lung and body weight reduction depending on its dose. |
| format | Article |
| id | doaj-art-16186d6287054cfb80bd310ed1af8bcb |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-16186d6287054cfb80bd310ed1af8bcb2025-02-03T01:23:40ZengWileyJournal of Toxicology1687-81911687-82052016-01-01201610.1155/2016/29732742973274Histopathological Study of Cyclosporine Pulmonary Toxicity in RatsSaid Said Elshama0Ayman El-Meghawry EL-Kenawy1Hosam-Eldin Hussein Osman2Department of Forensic Medicine and Clinical Toxicology, College of Medicine, Suez Canal University, P.O. Box 3457, Ismailia, EgyptTaif University, Taif, Saudi ArabiaTaif University, Taif, Saudi ArabiaCyclosporine is considered one of the common worldwide immunosuppressive drugs that are used for allograft rejection prevention. However, articles that address adverse effects of cyclosporine use on the vital organs such as lung are still few. This study aims to investigate pulmonary toxic effect of cyclosporine in rats by assessment of pulmonary histopathological changes using light and electron microscope examination. Sixty male adult albino rats were divided into three groups; each group consists of twenty rats. The first received physiological saline while the second and third groups received 25 and 40 mg/kg/day of cyclosporine, respectively, by gastric gavage for forty-five days. Cyclosporine reduced the lung and body weight with shrinkage or pyknotic nucleus of pneumocyte type II, degeneration of alveoli and interalveolar septum beside microvilli on the alveolar surface, emphysema, inflammatory cellular infiltration, pulmonary blood vessels congestion, and increase of fibrous tissues in the interstitial tissues and around alveoli with negative Periodic Acid-Schiff staining. Prolonged use of cyclosporine induced pulmonary ultrastructural and histopathological changes with the lung and body weight reduction depending on its dose.http://dx.doi.org/10.1155/2016/2973274 |
| spellingShingle | Said Said Elshama Ayman El-Meghawry EL-Kenawy Hosam-Eldin Hussein Osman Histopathological Study of Cyclosporine Pulmonary Toxicity in Rats Journal of Toxicology |
| title | Histopathological Study of Cyclosporine Pulmonary Toxicity in Rats |
| title_full | Histopathological Study of Cyclosporine Pulmonary Toxicity in Rats |
| title_fullStr | Histopathological Study of Cyclosporine Pulmonary Toxicity in Rats |
| title_full_unstemmed | Histopathological Study of Cyclosporine Pulmonary Toxicity in Rats |
| title_short | Histopathological Study of Cyclosporine Pulmonary Toxicity in Rats |
| title_sort | histopathological study of cyclosporine pulmonary toxicity in rats |
| url | http://dx.doi.org/10.1155/2016/2973274 |
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