Diagnostic and prognostic values of tsRNAs in lung cancer: a meta-analysis
Abstract Background Lung cancer (LC) is the leading cause of cancer-related death in humans. tRNA-derived small RNA (tsRNA) is a novel biomarker that plays a crucial role in the genesis and development of LC. In this study, we aimed to investigate the value of differentially expressed tsRNAs in LC t...
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2025-01-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-025-13536-y |
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| author | Cheng Tang Su-Xia Sun Chao Gu Chao-Juan Li Jin Xu Ke-Lei Su Dan-Dan Zhou Kuai Yu Qing-Ling Xiao Xiao-Li Chen |
| author_facet | Cheng Tang Su-Xia Sun Chao Gu Chao-Juan Li Jin Xu Ke-Lei Su Dan-Dan Zhou Kuai Yu Qing-Ling Xiao Xiao-Li Chen |
| author_sort | Cheng Tang |
| collection | DOAJ |
| description | Abstract Background Lung cancer (LC) is the leading cause of cancer-related death in humans. tRNA-derived small RNA (tsRNA) is a novel biomarker that plays a crucial role in the genesis and development of LC. In this study, we aimed to investigate the value of differentially expressed tsRNAs in LC through meta-analysis. Methods PubMed and Web of Science were searched for articles published up to January 10, 2024. Diagnostic odds ratios (DORs) and areas under the receiver operating characteristic curve (AUCs) were used to evaluate the potential of tsRNAs as diagnostic markers for LC. Furthermore, hazard ratios (HRs) and 95% confidence intervals (95% CIs) were used to analyze association of tsRNAs with LC prognosis. Results In total, 12 studies were included in the analysis. Our results indicated that the combined DOR of total tsRNAs for LC diagnosis was 7.32; the AUC was 0.81. Subgroup analysis revealed that high levels of tsRNAs in serum had good diagnostic efficacy (DOR = 16.56, AUC = 0.88). Moreover, a high tsRNAs level was associated with a worse prognosis in LC patients (HR = 1.59, 95% CI: 1.33–1.90). Conclusion Our findings suggest that a high tsRNAs level has potential value for diagnosis and prognosis of LC patients. However, further high-quality studies are needed to validate our results. |
| format | Article |
| id | doaj-art-16168a68b6d244a796a94cf921126a6c |
| institution | Kabale University |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-16168a68b6d244a796a94cf921126a6c2025-02-02T12:28:44ZengBMCBMC Cancer1471-24072025-01-0125111310.1186/s12885-025-13536-yDiagnostic and prognostic values of tsRNAs in lung cancer: a meta-analysisCheng Tang0Su-Xia Sun1Chao Gu2Chao-Juan Li3Jin Xu4Ke-Lei Su5Dan-Dan Zhou6Kuai Yu7Qing-Ling Xiao8Xiao-Li Chen9Department of Respiratory Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineDepartment of Respiratory Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineDepartment of Gastroenterology Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineDepartment of Respiratory Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineDepartment of Respiratory Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineDepartment of Respiratory Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineDepartment of Critical Care Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineNanjing University of Chinese MedicineDepartment of Respiratory Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineDepartment of Respiratory Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineAbstract Background Lung cancer (LC) is the leading cause of cancer-related death in humans. tRNA-derived small RNA (tsRNA) is a novel biomarker that plays a crucial role in the genesis and development of LC. In this study, we aimed to investigate the value of differentially expressed tsRNAs in LC through meta-analysis. Methods PubMed and Web of Science were searched for articles published up to January 10, 2024. Diagnostic odds ratios (DORs) and areas under the receiver operating characteristic curve (AUCs) were used to evaluate the potential of tsRNAs as diagnostic markers for LC. Furthermore, hazard ratios (HRs) and 95% confidence intervals (95% CIs) were used to analyze association of tsRNAs with LC prognosis. Results In total, 12 studies were included in the analysis. Our results indicated that the combined DOR of total tsRNAs for LC diagnosis was 7.32; the AUC was 0.81. Subgroup analysis revealed that high levels of tsRNAs in serum had good diagnostic efficacy (DOR = 16.56, AUC = 0.88). Moreover, a high tsRNAs level was associated with a worse prognosis in LC patients (HR = 1.59, 95% CI: 1.33–1.90). Conclusion Our findings suggest that a high tsRNAs level has potential value for diagnosis and prognosis of LC patients. However, further high-quality studies are needed to validate our results.https://doi.org/10.1186/s12885-025-13536-yDiagnosticPrognostictsRNAsLung cancerMeta-analysis |
| spellingShingle | Cheng Tang Su-Xia Sun Chao Gu Chao-Juan Li Jin Xu Ke-Lei Su Dan-Dan Zhou Kuai Yu Qing-Ling Xiao Xiao-Li Chen Diagnostic and prognostic values of tsRNAs in lung cancer: a meta-analysis BMC Cancer Diagnostic Prognostic tsRNAs Lung cancer Meta-analysis |
| title | Diagnostic and prognostic values of tsRNAs in lung cancer: a meta-analysis |
| title_full | Diagnostic and prognostic values of tsRNAs in lung cancer: a meta-analysis |
| title_fullStr | Diagnostic and prognostic values of tsRNAs in lung cancer: a meta-analysis |
| title_full_unstemmed | Diagnostic and prognostic values of tsRNAs in lung cancer: a meta-analysis |
| title_short | Diagnostic and prognostic values of tsRNAs in lung cancer: a meta-analysis |
| title_sort | diagnostic and prognostic values of tsrnas in lung cancer a meta analysis |
| topic | Diagnostic Prognostic tsRNAs Lung cancer Meta-analysis |
| url | https://doi.org/10.1186/s12885-025-13536-y |
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