Predictors of Length of Hospitalization for Neonatal Sepsis at Kenyatta Nation Hospital, Kenya: A Prospective Cross‐Sectional Study
ABSTRACT Background and Aims Neonatal sepsis is a major cause of neonatal mortality worldwide. It remains a detrimental bottleneck to the WHO goal of eradicating preventable deaths for children below 5 years of age by 2030. Though the risk factors for adverse clinical outcomes for neonatal sepsis ha...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Health Science Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/hsr2.70344 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832583138777235456 |
|---|---|
| author | Athman Khaltuma Tisho Patrick Mwirigi Mbugua Rose Bosire Simon Muturi Karanja |
| author_facet | Athman Khaltuma Tisho Patrick Mwirigi Mbugua Rose Bosire Simon Muturi Karanja |
| author_sort | Athman Khaltuma Tisho |
| collection | DOAJ |
| description | ABSTRACT Background and Aims Neonatal sepsis is a major cause of neonatal mortality worldwide. It remains a detrimental bottleneck to the WHO goal of eradicating preventable deaths for children below 5 years of age by 2030. Though the risk factors for adverse clinical outcomes for neonatal sepsis have been widely studied there is no universal consensus. Length of hospitalization is considered an indicator for adverse clinical outcome of neonatal sepsis. Markedly, literature is scarce regarding the drivers of extended hospitalization for neonatal sepsis in Kenya. Methodology This study determined the predictors of prolonged hospital stay for neonatal sepsis at the pediatric wards, KNH, Kenya. This was prospective cross‐sectional research carried out among 314 mother/neonate pairs. The neonates were confirmed to have sepsis. Logistic regression analysis was conducted to determine maternal and neonate status predictive of duration of hospitalization. Results The median duration of hospital stay was 11 days and the majority (52.9%) were hospitalized for more than 11 days. The findings identified that maternal age ≥ 35 years (OR = 3.72, 95% CI: 1.61–8.59, p = 0.03), UTI during pregnancy (OR = 1.82, 95% CI: 1.07–3.11, p = 0.03), not breastfeeding (OR = 2.31, 95% CI: 1.29–4.14, p = 0.005), convulsion (OR = 2.03, 95% CI: 1.22–3.37, p = 0.01), jaundice (OR = 1.45, 95% CI: 1.10–1.91, p = 0.002), reduced movements (OR = 1.72, 95% CI: 1.08–2.72, p = 0.02), low birthweight (OR = 6.1, 95% CI: 2.48–14.99, p < 0.001) and preterm birth (OR = 3.1, 95% CI: 1.64–5.86, p < 0.001) were significant predictors of longer hospital stay. Conclusion The findings provide insights into the factors that can be monitored to predict the prognosis of neonatal sepsis. Besides, remedies can target these variables to mitigate prolonged hospitalization and severity of neonatal sepsis. |
| format | Article |
| id | doaj-art-160725515cc3427a93795da9011654dc |
| institution | Kabale University |
| issn | 2398-8835 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj-art-160725515cc3427a93795da9011654dc2025-01-29T03:42:40ZengWileyHealth Science Reports2398-88352025-01-0181n/an/a10.1002/hsr2.70344Predictors of Length of Hospitalization for Neonatal Sepsis at Kenyatta Nation Hospital, Kenya: A Prospective Cross‐Sectional StudyAthman Khaltuma Tisho0Patrick Mwirigi Mbugua1Rose Bosire2Simon Muturi Karanja3Paediatric Ward Kenyatta National Hospital Nairobi KenyaSchool of Medicine Jomo Kenyatta University of Agriculture and Technology Juja KenyaCentre for Clinical Research Kenya Medical Research Institute Nairobi KenyaSchool of Public Health Medicine Jomo Kenyatta University of Agriculture and Technology Juja KenyaABSTRACT Background and Aims Neonatal sepsis is a major cause of neonatal mortality worldwide. It remains a detrimental bottleneck to the WHO goal of eradicating preventable deaths for children below 5 years of age by 2030. Though the risk factors for adverse clinical outcomes for neonatal sepsis have been widely studied there is no universal consensus. Length of hospitalization is considered an indicator for adverse clinical outcome of neonatal sepsis. Markedly, literature is scarce regarding the drivers of extended hospitalization for neonatal sepsis in Kenya. Methodology This study determined the predictors of prolonged hospital stay for neonatal sepsis at the pediatric wards, KNH, Kenya. This was prospective cross‐sectional research carried out among 314 mother/neonate pairs. The neonates were confirmed to have sepsis. Logistic regression analysis was conducted to determine maternal and neonate status predictive of duration of hospitalization. Results The median duration of hospital stay was 11 days and the majority (52.9%) were hospitalized for more than 11 days. The findings identified that maternal age ≥ 35 years (OR = 3.72, 95% CI: 1.61–8.59, p = 0.03), UTI during pregnancy (OR = 1.82, 95% CI: 1.07–3.11, p = 0.03), not breastfeeding (OR = 2.31, 95% CI: 1.29–4.14, p = 0.005), convulsion (OR = 2.03, 95% CI: 1.22–3.37, p = 0.01), jaundice (OR = 1.45, 95% CI: 1.10–1.91, p = 0.002), reduced movements (OR = 1.72, 95% CI: 1.08–2.72, p = 0.02), low birthweight (OR = 6.1, 95% CI: 2.48–14.99, p < 0.001) and preterm birth (OR = 3.1, 95% CI: 1.64–5.86, p < 0.001) were significant predictors of longer hospital stay. Conclusion The findings provide insights into the factors that can be monitored to predict the prognosis of neonatal sepsis. Besides, remedies can target these variables to mitigate prolonged hospitalization and severity of neonatal sepsis.https://doi.org/10.1002/hsr2.70344length of hospitalizationneonatal mortalityneonatal sepsis |
| spellingShingle | Athman Khaltuma Tisho Patrick Mwirigi Mbugua Rose Bosire Simon Muturi Karanja Predictors of Length of Hospitalization for Neonatal Sepsis at Kenyatta Nation Hospital, Kenya: A Prospective Cross‐Sectional Study Health Science Reports length of hospitalization neonatal mortality neonatal sepsis |
| title | Predictors of Length of Hospitalization for Neonatal Sepsis at Kenyatta Nation Hospital, Kenya: A Prospective Cross‐Sectional Study |
| title_full | Predictors of Length of Hospitalization for Neonatal Sepsis at Kenyatta Nation Hospital, Kenya: A Prospective Cross‐Sectional Study |
| title_fullStr | Predictors of Length of Hospitalization for Neonatal Sepsis at Kenyatta Nation Hospital, Kenya: A Prospective Cross‐Sectional Study |
| title_full_unstemmed | Predictors of Length of Hospitalization for Neonatal Sepsis at Kenyatta Nation Hospital, Kenya: A Prospective Cross‐Sectional Study |
| title_short | Predictors of Length of Hospitalization for Neonatal Sepsis at Kenyatta Nation Hospital, Kenya: A Prospective Cross‐Sectional Study |
| title_sort | predictors of length of hospitalization for neonatal sepsis at kenyatta nation hospital kenya a prospective cross sectional study |
| topic | length of hospitalization neonatal mortality neonatal sepsis |
| url | https://doi.org/10.1002/hsr2.70344 |
| work_keys_str_mv | AT athmankhaltumatisho predictorsoflengthofhospitalizationforneonatalsepsisatkenyattanationhospitalkenyaaprospectivecrosssectionalstudy AT patrickmwirigimbugua predictorsoflengthofhospitalizationforneonatalsepsisatkenyattanationhospitalkenyaaprospectivecrosssectionalstudy AT rosebosire predictorsoflengthofhospitalizationforneonatalsepsisatkenyattanationhospitalkenyaaprospectivecrosssectionalstudy AT simonmuturikaranja predictorsoflengthofhospitalizationforneonatalsepsisatkenyattanationhospitalkenyaaprospectivecrosssectionalstudy |