A New Case of dic(1;15)(p11;p11) in AML M1: Apropos of a Case and a Review of the Literature
Acute myelogenous leukemia (AML) develops as the consequence of a series of genetic changes in a hematopoietic precursor cell. Specific cytogenetic abnormalities have been identified by karyotype analysis in AML. One of the rare chromosomal abnormalities is a dicentric chromosome, which is defined a...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Case Reports in Genetics |
| Online Access: | http://dx.doi.org/10.1155/2013/462896 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563619365126144 |
|---|---|
| author | Deniz Gören Şahin Beyhan Durak Eren Gündüz Sevilhan Artan Olga Meltem Akay |
| author_facet | Deniz Gören Şahin Beyhan Durak Eren Gündüz Sevilhan Artan Olga Meltem Akay |
| author_sort | Deniz Gören Şahin |
| collection | DOAJ |
| description | Acute myelogenous leukemia (AML) develops as the consequence of a series of genetic changes in a hematopoietic precursor cell. Specific cytogenetic abnormalities have been identified by karyotype analysis in AML. One of the rare chromosomal abnormalities is a dicentric chromosome, which is defined as an aberrant chromosome having two centromeres. In the literature, a limited number of cases have been reported with dic(1;15) in myeloid disorders, but only one case has been reported with in acute megakaryoblastic leukemia. Herein, we report a case of acute myelogenous leukemia without maturation with a dic(1;15)(p11;p11), resulting in trisomy of the long arm of chromosome 1. To date, this is the second case of dic(1;15) in acute myelogenous leukemia and the first case in acute myeloblastic leukemia without maturation. |
| format | Article |
| id | doaj-art-15fc3e949e5940238ae2fd04a593fc7e |
| institution | Kabale University |
| issn | 2090-6544 2090-6552 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Genetics |
| spelling | doaj-art-15fc3e949e5940238ae2fd04a593fc7e2025-02-03T01:13:04ZengWileyCase Reports in Genetics2090-65442090-65522013-01-01201310.1155/2013/462896462896A New Case of dic(1;15)(p11;p11) in AML M1: Apropos of a Case and a Review of the LiteratureDeniz Gören Şahin0Beyhan Durak1Eren Gündüz2Sevilhan Artan3Olga Meltem Akay4Department of Hematology, School of Medicine, Eskisehir Osmangazi University, 26480 Eskisehir, TurkeyDepartment of Medical Genetics, School of Medicine, Eskisehir Osmangazi University, 26480 Eskisehir, TurkeyDepartment of Hematology, School of Medicine, Eskisehir Osmangazi University, 26480 Eskisehir, TurkeyDepartment of Medical Genetics, School of Medicine, Eskisehir Osmangazi University, 26480 Eskisehir, TurkeyDepartment of Hematology, School of Medicine, Eskisehir Osmangazi University, 26480 Eskisehir, TurkeyAcute myelogenous leukemia (AML) develops as the consequence of a series of genetic changes in a hematopoietic precursor cell. Specific cytogenetic abnormalities have been identified by karyotype analysis in AML. One of the rare chromosomal abnormalities is a dicentric chromosome, which is defined as an aberrant chromosome having two centromeres. In the literature, a limited number of cases have been reported with dic(1;15) in myeloid disorders, but only one case has been reported with in acute megakaryoblastic leukemia. Herein, we report a case of acute myelogenous leukemia without maturation with a dic(1;15)(p11;p11), resulting in trisomy of the long arm of chromosome 1. To date, this is the second case of dic(1;15) in acute myelogenous leukemia and the first case in acute myeloblastic leukemia without maturation.http://dx.doi.org/10.1155/2013/462896 |
| spellingShingle | Deniz Gören Şahin Beyhan Durak Eren Gündüz Sevilhan Artan Olga Meltem Akay A New Case of dic(1;15)(p11;p11) in AML M1: Apropos of a Case and a Review of the Literature Case Reports in Genetics |
| title | A New Case of dic(1;15)(p11;p11) in AML M1: Apropos of a Case and a Review of the Literature |
| title_full | A New Case of dic(1;15)(p11;p11) in AML M1: Apropos of a Case and a Review of the Literature |
| title_fullStr | A New Case of dic(1;15)(p11;p11) in AML M1: Apropos of a Case and a Review of the Literature |
| title_full_unstemmed | A New Case of dic(1;15)(p11;p11) in AML M1: Apropos of a Case and a Review of the Literature |
| title_short | A New Case of dic(1;15)(p11;p11) in AML M1: Apropos of a Case and a Review of the Literature |
| title_sort | new case of dic 1 15 p11 p11 in aml m1 apropos of a case and a review of the literature |
| url | http://dx.doi.org/10.1155/2013/462896 |
| work_keys_str_mv | AT denizgorensahin anewcaseofdic115p11p11inamlm1aproposofacaseandareviewoftheliterature AT beyhandurak anewcaseofdic115p11p11inamlm1aproposofacaseandareviewoftheliterature AT erengunduz anewcaseofdic115p11p11inamlm1aproposofacaseandareviewoftheliterature AT sevilhanartan anewcaseofdic115p11p11inamlm1aproposofacaseandareviewoftheliterature AT olgameltemakay anewcaseofdic115p11p11inamlm1aproposofacaseandareviewoftheliterature AT denizgorensahin newcaseofdic115p11p11inamlm1aproposofacaseandareviewoftheliterature AT beyhandurak newcaseofdic115p11p11inamlm1aproposofacaseandareviewoftheliterature AT erengunduz newcaseofdic115p11p11inamlm1aproposofacaseandareviewoftheliterature AT sevilhanartan newcaseofdic115p11p11inamlm1aproposofacaseandareviewoftheliterature AT olgameltemakay newcaseofdic115p11p11inamlm1aproposofacaseandareviewoftheliterature |