The association between sarcopenia and clinical outcomes among Chinese patients with triple-negative breast cancer: a retrospective study
PurposeThis study efforts to explore the association between sarcopenia, an age-related decline in muscle mass and physical function, and clinical outcomes in women with triple-negative breast cancer (TNBC).Methods and materialsThis retrospective study included women diagnosed with TNBC who received...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1402300/full |
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| author | Huayan Gu Teng Zhu JiaLing Ding Zhi Yang Yiqiao Lu Guilong Guo |
| author_facet | Huayan Gu Teng Zhu JiaLing Ding Zhi Yang Yiqiao Lu Guilong Guo |
| author_sort | Huayan Gu |
| collection | DOAJ |
| description | PurposeThis study efforts to explore the association between sarcopenia, an age-related decline in muscle mass and physical function, and clinical outcomes in women with triple-negative breast cancer (TNBC).Methods and materialsThis retrospective study included women diagnosed with TNBC who received breast surgery from December 2012 to December 2018. Skeletal muscle mass index (SMI) is utilized to evaluate sarcopenia, which was quantified by the cross-sectional area of muscle at the twelfth thoracic vertebra (T12). Disease-free survival (DFS) and overall survival (OS) are the endpoints. The association of sarcopenia with DFS and OS was statistically analyzed.ResultsThe study included 130 women in all, with a median age of 55 years (median follow-up, 53 months). Among them, 78 (58.5%) women had sarcopenia (SMI <28.01). 38 patients (29.2%) died and 49 patients (37.7%) experienced a recurrence of breast cancer throughout the follow-up period. Sarcopenia was demonstrated to be a significant predictive factor for both OS (HR,2.885; 95% CI, 1.349–6.169; p = 0.006) and DFS (HR,3.121; 95% CI, 1.578–6.175; p = 0.001) in the multivariate Cox proportional hazard model. There was no significant correlation seen between body mass index and either DFS (p = 0.156) or OS (P = 0.264). Logistic regression model further revealed that sarcopenia was a prognostic factor that was independently associated with both DFS (p = 0.001) and OS (p = 0.006).ConclusionsAmong women with TNBC, sarcopenia is associated with worse clinical outcomes. These patients with high risk might be candidates for individual programmed exercise and diet interventions to optimize survival outcomes. |
| format | Article |
| id | doaj-art-15f606e20b9f4b4499bf6bb1363aea96 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-15f606e20b9f4b4499bf6bb1363aea962025-02-06T07:09:44ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.14023001402300The association between sarcopenia and clinical outcomes among Chinese patients with triple-negative breast cancer: a retrospective studyHuayan Gu0Teng Zhu1JiaLing Ding2Zhi Yang3Yiqiao Lu4Guilong Guo5Department of Breast Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Breast Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Breast Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Breast Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Breast Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaPurposeThis study efforts to explore the association between sarcopenia, an age-related decline in muscle mass and physical function, and clinical outcomes in women with triple-negative breast cancer (TNBC).Methods and materialsThis retrospective study included women diagnosed with TNBC who received breast surgery from December 2012 to December 2018. Skeletal muscle mass index (SMI) is utilized to evaluate sarcopenia, which was quantified by the cross-sectional area of muscle at the twelfth thoracic vertebra (T12). Disease-free survival (DFS) and overall survival (OS) are the endpoints. The association of sarcopenia with DFS and OS was statistically analyzed.ResultsThe study included 130 women in all, with a median age of 55 years (median follow-up, 53 months). Among them, 78 (58.5%) women had sarcopenia (SMI <28.01). 38 patients (29.2%) died and 49 patients (37.7%) experienced a recurrence of breast cancer throughout the follow-up period. Sarcopenia was demonstrated to be a significant predictive factor for both OS (HR,2.885; 95% CI, 1.349–6.169; p = 0.006) and DFS (HR,3.121; 95% CI, 1.578–6.175; p = 0.001) in the multivariate Cox proportional hazard model. There was no significant correlation seen between body mass index and either DFS (p = 0.156) or OS (P = 0.264). Logistic regression model further revealed that sarcopenia was a prognostic factor that was independently associated with both DFS (p = 0.001) and OS (p = 0.006).ConclusionsAmong women with TNBC, sarcopenia is associated with worse clinical outcomes. These patients with high risk might be candidates for individual programmed exercise and diet interventions to optimize survival outcomes.https://www.frontiersin.org/articles/10.3389/fonc.2025.1402300/fullsarcopeniatriple-negative breast cancerTNBCassociationclinical outcomes |
| spellingShingle | Huayan Gu Teng Zhu JiaLing Ding Zhi Yang Yiqiao Lu Guilong Guo The association between sarcopenia and clinical outcomes among Chinese patients with triple-negative breast cancer: a retrospective study Frontiers in Oncology sarcopenia triple-negative breast cancer TNBC association clinical outcomes |
| title | The association between sarcopenia and clinical outcomes among Chinese patients with triple-negative breast cancer: a retrospective study |
| title_full | The association between sarcopenia and clinical outcomes among Chinese patients with triple-negative breast cancer: a retrospective study |
| title_fullStr | The association between sarcopenia and clinical outcomes among Chinese patients with triple-negative breast cancer: a retrospective study |
| title_full_unstemmed | The association between sarcopenia and clinical outcomes among Chinese patients with triple-negative breast cancer: a retrospective study |
| title_short | The association between sarcopenia and clinical outcomes among Chinese patients with triple-negative breast cancer: a retrospective study |
| title_sort | association between sarcopenia and clinical outcomes among chinese patients with triple negative breast cancer a retrospective study |
| topic | sarcopenia triple-negative breast cancer TNBC association clinical outcomes |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1402300/full |
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