A Proposed Role for Lymphatic Supermicrosurgery in the Management of Alzheimer's Disease: A Primer for Reconstructive Microsurgeons
The relatively recent discovery of a novel lymphatic system within the brain meninges has spurred interest in how waste products generated by neurons and glial cells—including proteins associated with Alzheimer's disease (AD) pathology such as amyloid beta (Aβ) and tau—are disposed of. Evidence...
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Thieme Medical Publishers, Inc.
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| Series: | Archives of Plastic Surgery |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/a-2513-4313 |
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| author | Joon Pio Hong Wei F. Chen Dung H. Nguyen Qingping Xie |
| author_facet | Joon Pio Hong Wei F. Chen Dung H. Nguyen Qingping Xie |
| author_sort | Joon Pio Hong |
| collection | DOAJ |
| description | The relatively recent discovery of a novel lymphatic system within the brain meninges has spurred interest in how waste products generated by neurons and glial cells—including proteins associated with Alzheimer's disease (AD) pathology such as amyloid beta (Aβ) and tau—are disposed of. Evidence is building that suggests disease progression in AD and other cognitive impairments could be explained by dysfunction in the brain's lymphatic system or obstruction of drainage. An interesting implication of this hypothesis is that, by relieving the obstruction of flow, lymphatic reconstruction along the drainage pathway could serve as a potential novel treatment. Should this concept prove true, it could represent a surgical solution to a problem for which only medical solutions have thus far been considered. This study is meant to serve as a primer for reconstructive microsurgeons, introducing the topic and current hypotheses about the potential role of lymphatic drainage in AD. A preview of current research evaluating the feasibility of lymphatic reconstruction as a surgical approach to improving Aβ clearance is provided, with the aim of inspiring others to design robust preclinical and clinical investigations into this intriguing hypothesis. |
| format | Article |
| id | doaj-art-15f01217c73846c7a0ef7870af6c757f |
| institution | Kabale University |
| issn | 2234-6163 2234-6171 |
| language | English |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | Archives of Plastic Surgery |
| spelling | doaj-art-15f01217c73846c7a0ef7870af6c757f2025-01-30T23:55:39ZengThieme Medical Publishers, Inc.Archives of Plastic Surgery2234-61632234-617110.1055/a-2513-4313A Proposed Role for Lymphatic Supermicrosurgery in the Management of Alzheimer's Disease: A Primer for Reconstructive MicrosurgeonsJoon Pio Hong0https://orcid.org/0000-0002-6208-9704Wei F. Chen1https://orcid.org/0000-0002-4163-6641Dung H. Nguyen2https://orcid.org/0000-0002-9494-7523Qingping Xie3https://orcid.org/0009-0009-5980-2431Department of Plastic Surgery, Asan Medical Center, University of Ulsan, Seoul, KoreaCleveland Clinic, Center for Lymphedema Research and Reconstruction, Cleveland, OhioStanford Women's Cancer Center, Palo Alto, CaliforniaQiushi Hospital Hangzhou, Hangzhou, People's Republic of ChinaThe relatively recent discovery of a novel lymphatic system within the brain meninges has spurred interest in how waste products generated by neurons and glial cells—including proteins associated with Alzheimer's disease (AD) pathology such as amyloid beta (Aβ) and tau—are disposed of. Evidence is building that suggests disease progression in AD and other cognitive impairments could be explained by dysfunction in the brain's lymphatic system or obstruction of drainage. An interesting implication of this hypothesis is that, by relieving the obstruction of flow, lymphatic reconstruction along the drainage pathway could serve as a potential novel treatment. Should this concept prove true, it could represent a surgical solution to a problem for which only medical solutions have thus far been considered. This study is meant to serve as a primer for reconstructive microsurgeons, introducing the topic and current hypotheses about the potential role of lymphatic drainage in AD. A preview of current research evaluating the feasibility of lymphatic reconstruction as a surgical approach to improving Aβ clearance is provided, with the aim of inspiring others to design robust preclinical and clinical investigations into this intriguing hypothesis.http://www.thieme-connect.de/DOI/DOI?10.1055/a-2513-4313Alzheimer's diseaseglymphatic systemmeningeal lymphatic systemintramural periarterial drainagelymphatic reconstructionlymphovenous anastomosissupermicrosurgery |
| spellingShingle | Joon Pio Hong Wei F. Chen Dung H. Nguyen Qingping Xie A Proposed Role for Lymphatic Supermicrosurgery in the Management of Alzheimer's Disease: A Primer for Reconstructive Microsurgeons Archives of Plastic Surgery Alzheimer's disease glymphatic system meningeal lymphatic system intramural periarterial drainage lymphatic reconstruction lymphovenous anastomosis supermicrosurgery |
| title | A Proposed Role for Lymphatic Supermicrosurgery in the Management of Alzheimer's Disease: A Primer for Reconstructive Microsurgeons |
| title_full | A Proposed Role for Lymphatic Supermicrosurgery in the Management of Alzheimer's Disease: A Primer for Reconstructive Microsurgeons |
| title_fullStr | A Proposed Role for Lymphatic Supermicrosurgery in the Management of Alzheimer's Disease: A Primer for Reconstructive Microsurgeons |
| title_full_unstemmed | A Proposed Role for Lymphatic Supermicrosurgery in the Management of Alzheimer's Disease: A Primer for Reconstructive Microsurgeons |
| title_short | A Proposed Role for Lymphatic Supermicrosurgery in the Management of Alzheimer's Disease: A Primer for Reconstructive Microsurgeons |
| title_sort | proposed role for lymphatic supermicrosurgery in the management of alzheimer s disease a primer for reconstructive microsurgeons |
| topic | Alzheimer's disease glymphatic system meningeal lymphatic system intramural periarterial drainage lymphatic reconstruction lymphovenous anastomosis supermicrosurgery |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/a-2513-4313 |
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