The growth diversity of preterm infants at 0–36 months corrected age in China: a real-world observational study
BackgroundPremature delivery interrupts the natural growth of the fetus. The postnatal healthy management of preterm infants still follows term standards after a postmenstrual age (PMA) of 40 weeks and there is a lack of research on the longitudinal dynamic postnatal growth tracks of preterm infants...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1506244/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832576318338760704 |
|---|---|
| author | Xia Wang Xia Wang Shuwen Feng Shuwen Feng Pu Yang Pu Yang Yuxin Wang Cong Wei Junwen Zheng Pin Liu Lihong Liao Xiao Yang Peibin Xu Junmei Bian Xiaoping Luo Yuanzhen Zhang Dongchi Zhao Dongchi Zhao |
| author_facet | Xia Wang Xia Wang Shuwen Feng Shuwen Feng Pu Yang Pu Yang Yuxin Wang Cong Wei Junwen Zheng Pin Liu Lihong Liao Xiao Yang Peibin Xu Junmei Bian Xiaoping Luo Yuanzhen Zhang Dongchi Zhao Dongchi Zhao |
| author_sort | Xia Wang |
| collection | DOAJ |
| description | BackgroundPremature delivery interrupts the natural growth of the fetus. The postnatal healthy management of preterm infants still follows term standards after a postmenstrual age (PMA) of 40 weeks and there is a lack of research on the longitudinal dynamic postnatal growth tracks of preterm infants.MethodsBased on the database established by the Wuhan University Internet+ Early Childhood Development Alliance in China, information on preterm infants, including birth registration and health follow-ups from 2016 to 2022, was incorporated into the health management system. Standardized anthropometric measurements of preterm infants were recorded from birth to a corrected age (CA) of 36 months. A generalized additive model based on location, scale, and shape was used to establish the percentile values and growth curves.ResultsIn total, 79,514 preterm infants were included in this study, and the birth weights at each gestational age (GA) were similar to Chinese standards. When evaluated by term birth weight, we found that the proportions of extrauterine growth retardation at a PMA of 40 weeks were all above 10% in the GA ≤34-week groups and reached between 17.19% and 55.56% in very preterm infants (VPIs). There was a high incidence of preterm infants with a weight below the third percentile in VPIs when referring to term standards at CAs of 0, 6, 12, 24, and 36 months (p < 0.001). We established natural growth curves of the preterm population with different GAs between CAs of 0 and 36 months, which indicated that the weight/length of late preterm infants was close to term standards while the growth trajectory of VPIs consistently lagged behind (p < 0.001).ConclusionOur study revealed the different growth trajectories of preterm infants with different GAs. A set of growth curves and percentile values for preterm infants of different GAs between CAs of 0 and 36 months were established, offering an optional method for growth assessment of this special population. |
| format | Article |
| id | doaj-art-15d4fb653be0496bb9e495e0033185ee |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-15d4fb653be0496bb9e495e0033185ee2025-01-31T06:40:16ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-01-011310.3389/fped.2025.15062441506244The growth diversity of preterm infants at 0–36 months corrected age in China: a real-world observational studyXia Wang0Xia Wang1Shuwen Feng2Shuwen Feng3Pu Yang4Pu Yang5Yuxin Wang6Cong Wei7Junwen Zheng8Pin Liu9Lihong Liao10Xiao Yang11Peibin Xu12Junmei Bian13Xiaoping Luo14Yuanzhen Zhang15Dongchi Zhao16Dongchi Zhao17Department of Pediatrics, Women and Children’s Hospital, Zhongnan Hospital, Wuhan University, Wuhan, ChinaChildren’s Digital Health and Data Center, Wuhan University, Wuhan, ChinaDepartment of Pediatrics, Women and Children’s Hospital, Zhongnan Hospital, Wuhan University, Wuhan, ChinaChildren’s Digital Health and Data Center, Wuhan University, Wuhan, ChinaDepartment of Pediatrics, Women and Children’s Hospital, Zhongnan Hospital, Wuhan University, Wuhan, ChinaChildren’s Digital Health and Data Center, Wuhan University, Wuhan, ChinaDepartment of Pediatrics, Women and Children’s Hospital, Zhongnan Hospital, Wuhan University, Wuhan, ChinaDepartment of Pediatrics, Women and Children’s Hospital, Zhongnan Hospital, Wuhan University, Wuhan, ChinaDepartment of Pediatrics, Women and Children’s Hospital, Zhongnan Hospital, Wuhan University, Wuhan, ChinaDepartment of Pediatrics, Women and Children’s Hospital, Zhongnan Hospital, Wuhan University, Wuhan, ChinaDepartment of Pediatrics, Women and Children’s Hospital, Zhongnan Hospital, Wuhan University, Wuhan, ChinaDepartment of Pediatrics, Women and Children’s Hospital, Zhongnan Hospital, Wuhan University, Wuhan, ChinaWomen and Children’s Hospital, Qingdao University, Wuhan, ChinaWuhan Tongren Hospital, Wuhan University, Wuhan, ChinaTongji Hospital, Huazhong University of Science and Technology, Wuhan, ChinaPrenatal Diagnosis Center, Women and Children’s Hospital, Zhongnan Hospital, Wuhan University, Wuhan, ChinaDepartment of Pediatrics, Women and Children’s Hospital, Zhongnan Hospital, Wuhan University, Wuhan, ChinaChildren’s Digital Health and Data Center, Wuhan University, Wuhan, ChinaBackgroundPremature delivery interrupts the natural growth of the fetus. The postnatal healthy management of preterm infants still follows term standards after a postmenstrual age (PMA) of 40 weeks and there is a lack of research on the longitudinal dynamic postnatal growth tracks of preterm infants.MethodsBased on the database established by the Wuhan University Internet+ Early Childhood Development Alliance in China, information on preterm infants, including birth registration and health follow-ups from 2016 to 2022, was incorporated into the health management system. Standardized anthropometric measurements of preterm infants were recorded from birth to a corrected age (CA) of 36 months. A generalized additive model based on location, scale, and shape was used to establish the percentile values and growth curves.ResultsIn total, 79,514 preterm infants were included in this study, and the birth weights at each gestational age (GA) were similar to Chinese standards. When evaluated by term birth weight, we found that the proportions of extrauterine growth retardation at a PMA of 40 weeks were all above 10% in the GA ≤34-week groups and reached between 17.19% and 55.56% in very preterm infants (VPIs). There was a high incidence of preterm infants with a weight below the third percentile in VPIs when referring to term standards at CAs of 0, 6, 12, 24, and 36 months (p < 0.001). We established natural growth curves of the preterm population with different GAs between CAs of 0 and 36 months, which indicated that the weight/length of late preterm infants was close to term standards while the growth trajectory of VPIs consistently lagged behind (p < 0.001).ConclusionOur study revealed the different growth trajectories of preterm infants with different GAs. A set of growth curves and percentile values for preterm infants of different GAs between CAs of 0 and 36 months were established, offering an optional method for growth assessment of this special population.https://www.frontiersin.org/articles/10.3389/fped.2025.1506244/fullpreterm infantreal-worldgrowth curvebody weightlength |
| spellingShingle | Xia Wang Xia Wang Shuwen Feng Shuwen Feng Pu Yang Pu Yang Yuxin Wang Cong Wei Junwen Zheng Pin Liu Lihong Liao Xiao Yang Peibin Xu Junmei Bian Xiaoping Luo Yuanzhen Zhang Dongchi Zhao Dongchi Zhao The growth diversity of preterm infants at 0–36 months corrected age in China: a real-world observational study Frontiers in Pediatrics preterm infant real-world growth curve body weight length |
| title | The growth diversity of preterm infants at 0–36 months corrected age in China: a real-world observational study |
| title_full | The growth diversity of preterm infants at 0–36 months corrected age in China: a real-world observational study |
| title_fullStr | The growth diversity of preterm infants at 0–36 months corrected age in China: a real-world observational study |
| title_full_unstemmed | The growth diversity of preterm infants at 0–36 months corrected age in China: a real-world observational study |
| title_short | The growth diversity of preterm infants at 0–36 months corrected age in China: a real-world observational study |
| title_sort | growth diversity of preterm infants at 0 36 months corrected age in china a real world observational study |
| topic | preterm infant real-world growth curve body weight length |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1506244/full |
| work_keys_str_mv | AT xiawang thegrowthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT xiawang thegrowthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT shuwenfeng thegrowthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT shuwenfeng thegrowthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT puyang thegrowthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT puyang thegrowthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT yuxinwang thegrowthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT congwei thegrowthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT junwenzheng thegrowthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT pinliu thegrowthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT lihongliao thegrowthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT xiaoyang thegrowthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT peibinxu thegrowthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT junmeibian thegrowthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT xiaopingluo thegrowthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT yuanzhenzhang thegrowthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT dongchizhao thegrowthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT dongchizhao thegrowthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT xiawang growthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT xiawang growthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT shuwenfeng growthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT shuwenfeng growthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT puyang growthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT puyang growthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT yuxinwang growthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT congwei growthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT junwenzheng growthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT pinliu growthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT lihongliao growthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT xiaoyang growthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT peibinxu growthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT junmeibian growthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT xiaopingluo growthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT yuanzhenzhang growthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT dongchizhao growthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy AT dongchizhao growthdiversityofpreterminfantsat036monthscorrectedageinchinaarealworldobservationalstudy |