AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia
Background. Recent data suggest that the renin-angiotensin system may be involved in triglyceride (TG) metabolism. We explored the effect of the common A1166C and C573T polymorphisms of the angiotensin II type 1 receptor (AT1R) gene on postprandial lipemia. Methods. Eighty-two subjects measured dayt...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/271030 |
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| author | B. Klop T. M. van den Berg A. P. Rietveld J. Chaves J. T. Real J. F. Ascaso R. Carmena J. W. F. Elte Manuel Castro Cabezas |
| author_facet | B. Klop T. M. van den Berg A. P. Rietveld J. Chaves J. T. Real J. F. Ascaso R. Carmena J. W. F. Elte Manuel Castro Cabezas |
| author_sort | B. Klop |
| collection | DOAJ |
| description | Background. Recent data suggest that the renin-angiotensin system may be involved in triglyceride (TG) metabolism. We explored the effect of the common A1166C and C573T polymorphisms of the angiotensin II type 1 receptor (AT1R) gene on postprandial lipemia. Methods. Eighty-two subjects measured daytime capillary TG, and postprandial lipemia was estimated as incremental area under the TG curve. The C573T and A1166C polymorphisms of the AT1R gene were determined. Results. Postprandial lipemia was significantly higher in homozygous carriers of the 1166-C allele (9.39±8.36 mM*h/L) compared to homozygous carriers of the 1166-A allele (2.02±6.20 mM*h/L) (P<0.05). Postprandial lipemia was similar for the different C573T polymorphisms. Conclusion. The 1166-C allele of the AT1R gene seems to be associated with increased postprandial lipemia. These data confirm the earlier described relationships between the renin-angiotensin axis and triglyceride metabolism. |
| format | Article |
| id | doaj-art-15d15e26730842bd99faa9f9cee9ce6b |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-15d15e26730842bd99faa9f9cee9ce6b2025-02-03T05:49:21ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322012-01-01201210.1155/2012/271030271030AT1 Receptor Gene Polymorphisms in relation to Postprandial LipemiaB. Klop0T. M. van den Berg1A. P. Rietveld2J. Chaves3J. T. Real4J. F. Ascaso5R. Carmena6J. W. F. Elte7Manuel Castro Cabezas8Department of Internal Medicine, Center for Diabetes and Vascular Medicine, St. Franciscus Gasthuis, P.O. Box 10900, 3004 BA Rotterdam, The NetherlandsDepartment of Internal Medicine, Center for Diabetes and Vascular Medicine, St. Franciscus Gasthuis, P.O. Box 10900, 3004 BA Rotterdam, The NetherlandsDepartment of Internal Medicine, Center for Diabetes and Vascular Medicine, St. Franciscus Gasthuis, P.O. Box 10900, 3004 BA Rotterdam, The NetherlandsDepartment of Endocrinology, University of Valencia, 46010 Valencia, SpainDepartment of Endocrinology, University of Valencia, 46010 Valencia, SpainUnidad de Genotipado y Diagnóstico Genético, Fundación Investigación Clínico de Valencia-INCLIVA, 46010 Valencia, SpainDepartment of Endocrinology, University of Valencia, 46010 Valencia, SpainDepartment of Internal Medicine, Center for Diabetes and Vascular Medicine, St. Franciscus Gasthuis, P.O. Box 10900, 3004 BA Rotterdam, The NetherlandsDepartment of Internal Medicine, Center for Diabetes and Vascular Medicine, St. Franciscus Gasthuis, P.O. Box 10900, 3004 BA Rotterdam, The NetherlandsBackground. Recent data suggest that the renin-angiotensin system may be involved in triglyceride (TG) metabolism. We explored the effect of the common A1166C and C573T polymorphisms of the angiotensin II type 1 receptor (AT1R) gene on postprandial lipemia. Methods. Eighty-two subjects measured daytime capillary TG, and postprandial lipemia was estimated as incremental area under the TG curve. The C573T and A1166C polymorphisms of the AT1R gene were determined. Results. Postprandial lipemia was significantly higher in homozygous carriers of the 1166-C allele (9.39±8.36 mM*h/L) compared to homozygous carriers of the 1166-A allele (2.02±6.20 mM*h/L) (P<0.05). Postprandial lipemia was similar for the different C573T polymorphisms. Conclusion. The 1166-C allele of the AT1R gene seems to be associated with increased postprandial lipemia. These data confirm the earlier described relationships between the renin-angiotensin axis and triglyceride metabolism.http://dx.doi.org/10.1155/2012/271030 |
| spellingShingle | B. Klop T. M. van den Berg A. P. Rietveld J. Chaves J. T. Real J. F. Ascaso R. Carmena J. W. F. Elte Manuel Castro Cabezas AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia International Journal of Vascular Medicine |
| title | AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia |
| title_full | AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia |
| title_fullStr | AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia |
| title_full_unstemmed | AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia |
| title_short | AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia |
| title_sort | at1 receptor gene polymorphisms in relation to postprandial lipemia |
| url | http://dx.doi.org/10.1155/2012/271030 |
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