Stroke associated with microvascular tumoral infiltration in a patient with metastatic breast cancer
Leptomeningeal carcinomatosis is a form of advanced metastatic disease conferring poor prognosis, most commonly associated with melanoma, small cell lung cancer, and breast cancer. In rare cases it has been shown to be associated with stroke thought to be related to vasculopathy caused by tumoral in...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043324013840 |
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| author | Joshua Mangerel, MD Andres Rodriguez-Sein, MD Daniel Masri, MD |
| author_facet | Joshua Mangerel, MD Andres Rodriguez-Sein, MD Daniel Masri, MD |
| author_sort | Joshua Mangerel, MD |
| collection | DOAJ |
| description | Leptomeningeal carcinomatosis is a form of advanced metastatic disease conferring poor prognosis, most commonly associated with melanoma, small cell lung cancer, and breast cancer. In rare cases it has been shown to be associated with stroke thought to be related to vasculopathy caused by tumoral infiltration of cerebral vasculature. We present a case of acute cerebellar infarction in a patient with metastatic breast cancer complicated by leptomeningeal carcinomatosis, admitted for worsening metastatic disease. We include images clearly demonstrating interval development of diffusion restriction at a site of macroscopically stable leptomeningeal disease, in the setting of new onset focal neurologic deficits clinically consistent with acute stroke. |
| format | Article |
| id | doaj-art-15cc10b9358045e7aebb0fac89e62bac |
| institution | Kabale University |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-15cc10b9358045e7aebb0fac89e62bac2025-01-18T05:04:09ZengElsevierRadiology Case Reports1930-04332025-03-0120316201623Stroke associated with microvascular tumoral infiltration in a patient with metastatic breast cancerJoshua Mangerel, MD0Andres Rodriguez-Sein, MD1Daniel Masri, MD2Corresponding author.; Maimonides Medical Center, Department of Radiology 4802 10th Avenue, Brooklyn, NY 11219, USAMaimonides Medical Center, Department of Radiology 4802 10th Avenue, Brooklyn, NY 11219, USAMaimonides Medical Center, Department of Radiology 4802 10th Avenue, Brooklyn, NY 11219, USALeptomeningeal carcinomatosis is a form of advanced metastatic disease conferring poor prognosis, most commonly associated with melanoma, small cell lung cancer, and breast cancer. In rare cases it has been shown to be associated with stroke thought to be related to vasculopathy caused by tumoral infiltration of cerebral vasculature. We present a case of acute cerebellar infarction in a patient with metastatic breast cancer complicated by leptomeningeal carcinomatosis, admitted for worsening metastatic disease. We include images clearly demonstrating interval development of diffusion restriction at a site of macroscopically stable leptomeningeal disease, in the setting of new onset focal neurologic deficits clinically consistent with acute stroke.http://www.sciencedirect.com/science/article/pii/S1930043324013840Leptomeningeal carcinomatosisStrokeMetastatic breast cancer |
| spellingShingle | Joshua Mangerel, MD Andres Rodriguez-Sein, MD Daniel Masri, MD Stroke associated with microvascular tumoral infiltration in a patient with metastatic breast cancer Radiology Case Reports Leptomeningeal carcinomatosis Stroke Metastatic breast cancer |
| title | Stroke associated with microvascular tumoral infiltration in a patient with metastatic breast cancer |
| title_full | Stroke associated with microvascular tumoral infiltration in a patient with metastatic breast cancer |
| title_fullStr | Stroke associated with microvascular tumoral infiltration in a patient with metastatic breast cancer |
| title_full_unstemmed | Stroke associated with microvascular tumoral infiltration in a patient with metastatic breast cancer |
| title_short | Stroke associated with microvascular tumoral infiltration in a patient with metastatic breast cancer |
| title_sort | stroke associated with microvascular tumoral infiltration in a patient with metastatic breast cancer |
| topic | Leptomeningeal carcinomatosis Stroke Metastatic breast cancer |
| url | http://www.sciencedirect.com/science/article/pii/S1930043324013840 |
| work_keys_str_mv | AT joshuamangerelmd strokeassociatedwithmicrovasculartumoralinfiltrationinapatientwithmetastaticbreastcancer AT andresrodriguezseinmd strokeassociatedwithmicrovasculartumoralinfiltrationinapatientwithmetastaticbreastcancer AT danielmasrimd strokeassociatedwithmicrovasculartumoralinfiltrationinapatientwithmetastaticbreastcancer |