Serial Assessment of Immune Status by Circulating CD8+ Effector T Cell Frequencies for Posttransplant Infectious Complications
To clarify the role of CD8+ effector T cells for infectious complications, 92 recipients were classified according to the hierarchical clustering of preoperative CD8+CD45 isoforms: Group I was naive, Group II was effector memory, and Group III was effector (E) T cell-dominant. The posttransplant inf...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2008/718386 |
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| _version_ | 1832552140036374528 |
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| author | Shinji Uemoto Kazue Ozawa Hiroto Egawa Yasutsugu Takada Hiroshi Sato Satoshi Teramukai Mureo Kasahara Kohei Ogawa Masako Ono Kenji Takai Masanori Fukushima Kayo Inaba Koichi Tanaka |
| author_facet | Shinji Uemoto Kazue Ozawa Hiroto Egawa Yasutsugu Takada Hiroshi Sato Satoshi Teramukai Mureo Kasahara Kohei Ogawa Masako Ono Kenji Takai Masanori Fukushima Kayo Inaba Koichi Tanaka |
| author_sort | Shinji Uemoto |
| collection | DOAJ |
| description | To clarify the role of CD8+ effector T cells for infectious complications, 92 recipients were classified according to the hierarchical clustering of preoperative CD8+CD45 isoforms: Group I was naive, Group II was effector memory, and Group III was effector (E) T cell-dominant. The posttransplant infection rates progressively increased from 29% in Group I to 64.3% in Group III recipients. The posttransplant immune status was compared with the pretransplant status, based on the measure (% difference) and its graphical form (scatter plot). In Groups I and II, both approaches showed a strong upward deviation from pretransplant status upon posttransplant infection, indicating an enhanced clearance of pathogens. In Group III, in contrast, both approaches showed a clear downward deviation from preoperative status, indicating deficient cytotoxicity. The % E difference and scatter plot can be used as a useful indicator of a posttransplant infectious complication. |
| format | Article |
| id | doaj-art-15c9f8272f1640448a7804202280d163 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-15c9f8272f1640448a7804202280d1632025-02-03T05:59:27ZengWileyClinical and Developmental Immunology1740-25221740-25302008-01-01200810.1155/2008/718386718386Serial Assessment of Immune Status by Circulating CD8+ Effector T Cell Frequencies for Posttransplant Infectious ComplicationsShinji Uemoto0Kazue Ozawa1Hiroto Egawa2Yasutsugu Takada3Hiroshi Sato4Satoshi Teramukai5Mureo Kasahara6Kohei Ogawa7Masako Ono8Kenji Takai9Masanori Fukushima10Kayo Inaba11Koichi Tanaka12Department of Transplantation and Immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, JapanHepatic Disease Research Institute, Kyoto 605-0981, JapanDepartment of Transplantation and Immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, JapanDepartment of Transplantation and Immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, JapanDivision of Bioscience, Shiga University of Medical Science, Shiga 520-2192, JapanDivision of Clinical Trial Design and Management, Translational Research Center, Kyoto University Hospital, Kyoto 606-8507, JapanDepartment of Transplantation and Immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, JapanDepartment of Transplantation and Immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, JapanHepatic Disease Research Institute, Kyoto 605-0981, JapanDivision of Cellular Immunology, SRL Inc., Tokyo 192-8535, JapanDivision of Bioscience, Shiga University of Medical Science, Shiga 520-2192, JapanDivision of Systemic Life Science, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, JapanInstitute of Biomedical Research and Innovation, Hyogo 650-0047, JapanTo clarify the role of CD8+ effector T cells for infectious complications, 92 recipients were classified according to the hierarchical clustering of preoperative CD8+CD45 isoforms: Group I was naive, Group II was effector memory, and Group III was effector (E) T cell-dominant. The posttransplant infection rates progressively increased from 29% in Group I to 64.3% in Group III recipients. The posttransplant immune status was compared with the pretransplant status, based on the measure (% difference) and its graphical form (scatter plot). In Groups I and II, both approaches showed a strong upward deviation from pretransplant status upon posttransplant infection, indicating an enhanced clearance of pathogens. In Group III, in contrast, both approaches showed a clear downward deviation from preoperative status, indicating deficient cytotoxicity. The % E difference and scatter plot can be used as a useful indicator of a posttransplant infectious complication.http://dx.doi.org/10.1155/2008/718386 |
| spellingShingle | Shinji Uemoto Kazue Ozawa Hiroto Egawa Yasutsugu Takada Hiroshi Sato Satoshi Teramukai Mureo Kasahara Kohei Ogawa Masako Ono Kenji Takai Masanori Fukushima Kayo Inaba Koichi Tanaka Serial Assessment of Immune Status by Circulating CD8+ Effector T Cell Frequencies for Posttransplant Infectious Complications Clinical and Developmental Immunology |
| title | Serial Assessment of Immune Status by Circulating CD8+ Effector T Cell Frequencies for Posttransplant Infectious Complications |
| title_full | Serial Assessment of Immune Status by Circulating CD8+ Effector T Cell Frequencies for Posttransplant Infectious Complications |
| title_fullStr | Serial Assessment of Immune Status by Circulating CD8+ Effector T Cell Frequencies for Posttransplant Infectious Complications |
| title_full_unstemmed | Serial Assessment of Immune Status by Circulating CD8+ Effector T Cell Frequencies for Posttransplant Infectious Complications |
| title_short | Serial Assessment of Immune Status by Circulating CD8+ Effector T Cell Frequencies for Posttransplant Infectious Complications |
| title_sort | serial assessment of immune status by circulating cd8 effector t cell frequencies for posttransplant infectious complications |
| url | http://dx.doi.org/10.1155/2008/718386 |
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